A novel gel based on an ionic complex from a dendronized polymer and ciprofloxacin: Evaluation of its use for controlled topical drug release

The development and characterization of a novel, gel-type material based on a dendronized polymer (DP) loaded with ciprofloxacin (CIP), and the evaluation of its possible use for controlled drug release, are presented in this work. DP showed biocompatible and non-toxic behaviors in cultured cells, b...

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Veröffentlicht in:	Materials Science & Engineering C 2016-12, Vol.69, p.236-246
Hauptverfasser:	García, Mónica C., Cuggino, Julio C., Rosset, Clarisa I., Páez, Paulina L., Strumia, Miriam C., Manzo, Ruben H., Alovero, Fabiana L., Alvarez Igarzabal, Cecilia I., Jimenez-Kairuz, Alvaro F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Assaying Bacteria Biocompatibility Cell Line Cell Survival - drug effects Ciprofloxacin Ciprofloxacin - chemistry Ciprofloxacin - metabolism Ciprofloxacin - pharmacology Dendrimers - chemistry Dendronized polymer Drug Carriers - chemistry Drug Carriers - toxicity Drug controlled release Drug delivery systems Drug Liberation Gels - chemistry Human behavior Humans Hydrogel Hydrogen-Ion Concentration In vitro testing Ions - chemistry Microbial Sensitivity Tests Optimization Polyelectrolyte-drug complexes Polymers - chemistry Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Rabbits Rheology Skin (anatomy) Skin - drug effects Spectroscopy, Fourier Transform Infrared Staphylococcus aureus Staphylococcus aureus - drug effects
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