Tunable conjugation densities of camptothecin on hyaluronic acid for tumor targeting and reduction-triggered release

[Display omitted] Micelles self-assembled from drug-conjugated polymers indicate advantages in alleviating the premature release before reaching the intended site. Hyaluronic acid (HA) is known to specifically bind with a transmembrane glycoprotein CD44, overexpressed in many types of cancerous cell...

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Veröffentlicht in:	Acta biomaterialia 2016-10, Vol.43, p.195-207
Hauptverfasser:	Chen, Zhoujiang, He, Nan, Chen, Maohua, Zhao, Long, Li, Xiaohong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Backbone Camptothecin - chemistry Camptothecin - pharmacology Camptothecin - therapeutic use Cell Proliferation - drug effects Cellular uptake Conjugation Drug Liberation Drug-conjugated micelle Drugs Dynamic Light Scattering Endocytosis - drug effects Humans Hyaluronic acid Hyaluronic Acid - chemical synthesis Hyaluronic Acid - chemistry Liver MCF-7 Cells Mice Micelles Neoplasm Metastasis Neoplasms - drug therapy Neoplasms - pathology Particle Size Reduction-triggered release Substitution degree Survival Analysis Tissue Distribution - drug effects Tumor targeting Tumors Uptakes
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