Targeted systemic mesenchymal stem cell delivery using hyaluronate – wheat germ agglutinin conjugate

Abstract A variety of receptors for hyaluronate (HA), a natural linear polysaccharide, were found in the body, which have been exploited as target sites for HA-based drug delivery systems. In this work, mesenchymal stem cells (MSCs) were surface-modified with HA - wheat germ agglutinin (WGA) conjuga...

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Veröffentlicht in:	Biomaterials 2016-11, Vol.106, p.217-227
Hauptverfasser:	Kim, Yun Seop, Kong, Won Ho, Kim, Hyemin, Hahn, Sei Kwang
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Cell surface modification Cells, Cultured Conjugates Conjugation Dentistry Drug delivery systems Fluorescence Hyaluronate Hyaluronic Acid - chemistry Hyaluronic Acid - pharmacokinetics Imaging Liver Liver - cytology Liver - metabolism Liver - physiology Liver Regeneration - physiology Male Mesenchymal stem cell Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - physiology Nanocapsules - chemistry Nanocapsules - ultrastructure Nanoconjugates - chemistry Nanoconjugates - ultrastructure Organ Specificity - physiology Rats Rats, Sprague-Dawley Stem cells Targeted delivery Tissue Distribution Wheat germ Wheat germ agglutinin Wheat Germ Agglutinins - chemistry
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