Metformin potentiates the anticancer activities of gemcitabine and cisplatin against cholangiocarcinoma cells in vitro and in vivo

Metformin, an oral biguanide drug used to treat type 2 diabetes, has displayed anticancer activities in several types of cancer cells. The combination of gemcitabine and cisplatin is the standard chemotherapy regimen for cholangiocarcinoma, but its benefit is limited. The present study aimed to inve...

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Veröffentlicht in:	Oncology reports 2016-12, Vol.36 (6), p.3488-3496
Hauptverfasser:	Zhu, Hua-Qiang, Ma, Jin-Ben, Song, Xie, Gao, Heng-Jun, Ma, Chao-Qun, Chang, Hong, Li, Hong-Guang, Liu, Fang-Feng, Lu, Jun, Zhou, Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidiabetics Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Bile Duct Neoplasms - drug therapy Breast cancer Cancer Cancer therapies Cell culture Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Cholangiocarcinoma Cholangiocarcinoma - drug therapy Cisplatin Cisplatin - administration & dosage Cytotoxicity Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxyribonucleic acid Diabetes DNA Drug dosages Drug Synergism Esophagus Flow cytometry G1 Phase Cell Cycle Checkpoints Gastric cancer Gemcitabine Humans Kinases Liver cancer Male Medical prognosis Metformin Metformin - administration & dosage Methods Mice Mice, Inbred BALB C Mice, Nude Observations Patient outcomes Phosphorylation Proteins Tumors Xenograft Model Antitumor Assays
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