Determination of Pharmacokinetics Differences of Ammuxetine Isomers in Rat Plasma Using On-Line Solid Phase Extraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry

An on-line solid phase extraction (SPE) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to determine the novel chiral antidepressant, S/R-ammuxetine in rat plasma. The plasma sample pretreatment consisted of the following steps: protein precipitation using...

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Veröffentlicht in:	Chinese Journal of Analytical Chemistry 2014-12, Vol.42 (12), p.1717-1722
Hauptverfasser:	LI, Ying, FENG, Hang, GONG, Wei, YU, Fang-Lin, XIE, Xiang-Yang, HE, Xin-Hua, You-Zhi, Zhang, MEI, Xing-Guo
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography Columns (process) Extraction Isomers Liquids Mass spectrometry On-line systems Separation
Online-Zugang:	Volltext
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