Self-Powered Wireless Affinity-Based Biosensor Based on Integration of Paper-Based Microfluidics and Self-Assembled RFID Antennas
This paper presents a wireless, self-powered, affinity-based biosensor based on the integration of paper-based microfluidics with our previously reported method for self-assembling radio-frequency (RF) antennas. At the core of the proposed approach is a silver-enhancement technique that grows portio...
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| Veröffentlicht in: | IEEE transactions on biomedical circuits and systems 2016-08, Vol.10 (4), p.799-806 |
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| container_title | IEEE transactions on biomedical circuits and systems |
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| creator | Mingquan Yuan Alocilja, Evangelyn C. Chakrabartty, Shantanu |
| description | This paper presents a wireless, self-powered, affinity-based biosensor based on the integration of paper-based microfluidics with our previously reported method for self-assembling radio-frequency (RF) antennas. At the core of the proposed approach is a silver-enhancement technique that grows portions of a RF antenna in regions where target antigens hybridize with target specific affinity probes. The hybridization regions are defined by a network of nitrocellulose based microfluidic channels which implement a self-powered approach to sample the reagent and control its flow and mixing. The integration substrate for the biosensor has been constructed using polyethylene and the patterning of the antenna on the substrate has been achieved using a low-cost ink-jet printing technique. The substrate has been integrated with passive radio-frequency identification (RFID) tags to demonstrate that the resulting sensor-tag can be used for continuous monitoring in a food supply-chain where direct measurement of analytes is typically considered to be impractical. We validate the proof-of-concept operation of the proposed sensor-tag using IgG as a model analyte and using a 915 MHz Ultra-high-frequency (UHF) RFID tagging technology. |
| doi_str_mv | 10.1109/TBCAS.2016.2535245 |
| format | Article |
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At the core of the proposed approach is a silver-enhancement technique that grows portions of a RF antenna in regions where target antigens hybridize with target specific affinity probes. The hybridization regions are defined by a network of nitrocellulose based microfluidic channels which implement a self-powered approach to sample the reagent and control its flow and mixing. The integration substrate for the biosensor has been constructed using polyethylene and the patterning of the antenna on the substrate has been achieved using a low-cost ink-jet printing technique. The substrate has been integrated with passive radio-frequency identification (RFID) tags to demonstrate that the resulting sensor-tag can be used for continuous monitoring in a food supply-chain where direct measurement of analytes is typically considered to be impractical. We validate the proof-of-concept operation of the proposed sensor-tag using IgG as a model analyte and using a 915 MHz Ultra-high-frequency (UHF) RFID tagging technology.</description><identifier>ISSN: 1932-4545</identifier><identifier>EISSN: 1940-9990</identifier><identifier>DOI: 10.1109/TBCAS.2016.2535245</identifier><identifier>PMID: 27214914</identifier><identifier>CODEN: ITBCCW</identifier><language>eng</language><publisher>United States: IEEE</publisher><subject>Antennas ; Antibodies, Immobilized - chemistry ; Antibodies, Immobilized - immunology ; Antigens - analysis ; Antigens - immunology ; Biosensing Techniques - instrumentation ; Biosensing Techniques - methods ; Biosensors ; Channels ; Electrodes ; Flexible electronics ; Food Quality ; Gold - chemistry ; ink-jet printing ; Metal Nanoparticles - chemistry ; micro-monopole antenna ; Microfluidics ; paper-based microfluidics ; Polyethylenes ; Radio frequency ; Radio frequency identification ; Radio Frequency Identification Device ; radio-frequency identification (RFID) ; Radiofrequency identification ; self-assemble ; self-powered sensing ; Silver ; silver enhancement ; Substrates ; UHF ; wireless biosensor ; Wireless Technology</subject><ispartof>IEEE transactions on biomedical circuits and systems, 2016-08, Vol.10 (4), p.799-806</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-bf35b6dee9dc7a35fdaffc7072060a1dbadb2a288d08d49c534efc3805f74f3c3</citedby><cites>FETCH-LOGICAL-c461t-bf35b6dee9dc7a35fdaffc7072060a1dbadb2a288d08d49c534efc3805f74f3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/7470569$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,776,780,792,27903,27904,54737</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/7470569$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27214914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mingquan Yuan</creatorcontrib><creatorcontrib>Alocilja, Evangelyn C.</creatorcontrib><creatorcontrib>Chakrabartty, Shantanu</creatorcontrib><title>Self-Powered Wireless Affinity-Based Biosensor Based on Integration of Paper-Based Microfluidics and Self-Assembled RFID Antennas</title><title>IEEE transactions on biomedical circuits and systems</title><addtitle>TBCAS</addtitle><addtitle>IEEE Trans Biomed Circuits Syst</addtitle><description>This paper presents a wireless, self-powered, affinity-based biosensor based on the integration of paper-based microfluidics with our previously reported method for self-assembling radio-frequency (RF) antennas. At the core of the proposed approach is a silver-enhancement technique that grows portions of a RF antenna in regions where target antigens hybridize with target specific affinity probes. The hybridization regions are defined by a network of nitrocellulose based microfluidic channels which implement a self-powered approach to sample the reagent and control its flow and mixing. The integration substrate for the biosensor has been constructed using polyethylene and the patterning of the antenna on the substrate has been achieved using a low-cost ink-jet printing technique. The substrate has been integrated with passive radio-frequency identification (RFID) tags to demonstrate that the resulting sensor-tag can be used for continuous monitoring in a food supply-chain where direct measurement of analytes is typically considered to be impractical. We validate the proof-of-concept operation of the proposed sensor-tag using IgG as a model analyte and using a 915 MHz Ultra-high-frequency (UHF) RFID tagging technology.</description><subject>Antennas</subject><subject>Antibodies, Immobilized - chemistry</subject><subject>Antibodies, Immobilized - immunology</subject><subject>Antigens - analysis</subject><subject>Antigens - immunology</subject><subject>Biosensing Techniques - instrumentation</subject><subject>Biosensing Techniques - methods</subject><subject>Biosensors</subject><subject>Channels</subject><subject>Electrodes</subject><subject>Flexible electronics</subject><subject>Food Quality</subject><subject>Gold - chemistry</subject><subject>ink-jet printing</subject><subject>Metal Nanoparticles - chemistry</subject><subject>micro-monopole antenna</subject><subject>Microfluidics</subject><subject>paper-based microfluidics</subject><subject>Polyethylenes</subject><subject>Radio frequency</subject><subject>Radio frequency identification</subject><subject>Radio Frequency Identification Device</subject><subject>radio-frequency identification (RFID)</subject><subject>Radiofrequency identification</subject><subject>self-assemble</subject><subject>self-powered sensing</subject><subject>Silver</subject><subject>silver enhancement</subject><subject>Substrates</subject><subject>UHF</subject><subject>wireless biosensor</subject><subject>Wireless Technology</subject><issn>1932-4545</issn><issn>1940-9990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><sourceid>EIF</sourceid><recordid>eNqNks1u1DAUhS1ERUvhBUBCkdiwyeDfOF5mphRGKqKiRSwjx75GrjL21E6Euuyb4-lMu2ADK1_b3znWvccIvSF4QQhWH6-Xq-5qQTFpFlQwQbl4hk6I4rhWSuHnu5rRmgsujtHLnG8wFg1V9AU6ppISrgg_QfdXMLr6Mv6GBLb66ROMkHPVOeeDn-7qpc7lfOljhpBjqvb7GKp1mOBX0pMvdXTVpd5COtBfvUnRjbO33uRKB1s9PNLlDJthLMD38_VZ1RWDEHR-hY6cHjO8Pqyn6Mf5p-vVl_ri2-f1qruoDW_IVA-OiaGxAMoaqZlwVjtnJJYUN1gTO2g7UE3b1uLWcmUE4-AMa7Fwkjtm2Cn6sPfdpng7Q576jc8GxlEHiHPuSctEwwRr1X-ghLSywUXybxS3DaaUy4K-_wu9iXMKpecdJRVhrCGFonuqzDDnBK7fJr_R6a4nuN_F3j_E3u9i7w-xF9G7g_U8bMA-SR5zLsDbPeAB4Olaclm-hGJ_APvrsPg</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Mingquan Yuan</creator><creator>Alocilja, Evangelyn C.</creator><creator>Chakrabartty, Shantanu</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. (IEEE)</general><scope>97E</scope><scope>RIA</scope><scope>RIE</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SP</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope><scope>L7M</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201608</creationdate><title>Self-Powered Wireless Affinity-Based Biosensor Based on Integration of Paper-Based Microfluidics and Self-Assembled RFID Antennas</title><author>Mingquan Yuan ; Alocilja, Evangelyn C. ; Chakrabartty, Shantanu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-bf35b6dee9dc7a35fdaffc7072060a1dbadb2a288d08d49c534efc3805f74f3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antennas</topic><topic>Antibodies, Immobilized - chemistry</topic><topic>Antibodies, Immobilized - immunology</topic><topic>Antigens - analysis</topic><topic>Antigens - immunology</topic><topic>Biosensing Techniques - instrumentation</topic><topic>Biosensing Techniques - methods</topic><topic>Biosensors</topic><topic>Channels</topic><topic>Electrodes</topic><topic>Flexible electronics</topic><topic>Food Quality</topic><topic>Gold - chemistry</topic><topic>ink-jet printing</topic><topic>Metal Nanoparticles - chemistry</topic><topic>micro-monopole antenna</topic><topic>Microfluidics</topic><topic>paper-based microfluidics</topic><topic>Polyethylenes</topic><topic>Radio frequency</topic><topic>Radio frequency identification</topic><topic>Radio Frequency Identification Device</topic><topic>radio-frequency identification (RFID)</topic><topic>Radiofrequency identification</topic><topic>self-assemble</topic><topic>self-powered sensing</topic><topic>Silver</topic><topic>silver enhancement</topic><topic>Substrates</topic><topic>UHF</topic><topic>wireless biosensor</topic><topic>Wireless Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mingquan Yuan</creatorcontrib><creatorcontrib>Alocilja, Evangelyn C.</creatorcontrib><creatorcontrib>Chakrabartty, Shantanu</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 2005–Present</collection><collection>IEEE All-Society Periodicals Package (ASPP) 1998–Present</collection><collection>IEEE/IET Electronic Library</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>IEEE transactions on biomedical circuits and systems</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Mingquan Yuan</au><au>Alocilja, Evangelyn C.</au><au>Chakrabartty, Shantanu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self-Powered Wireless Affinity-Based Biosensor Based on Integration of Paper-Based Microfluidics and Self-Assembled RFID Antennas</atitle><jtitle>IEEE transactions on biomedical circuits and systems</jtitle><stitle>TBCAS</stitle><addtitle>IEEE Trans Biomed Circuits Syst</addtitle><date>2016-08</date><risdate>2016</risdate><volume>10</volume><issue>4</issue><spage>799</spage><epage>806</epage><pages>799-806</pages><issn>1932-4545</issn><eissn>1940-9990</eissn><coden>ITBCCW</coden><abstract>This paper presents a wireless, self-powered, affinity-based biosensor based on the integration of paper-based microfluidics with our previously reported method for self-assembling radio-frequency (RF) antennas. At the core of the proposed approach is a silver-enhancement technique that grows portions of a RF antenna in regions where target antigens hybridize with target specific affinity probes. The hybridization regions are defined by a network of nitrocellulose based microfluidic channels which implement a self-powered approach to sample the reagent and control its flow and mixing. The integration substrate for the biosensor has been constructed using polyethylene and the patterning of the antenna on the substrate has been achieved using a low-cost ink-jet printing technique. The substrate has been integrated with passive radio-frequency identification (RFID) tags to demonstrate that the resulting sensor-tag can be used for continuous monitoring in a food supply-chain where direct measurement of analytes is typically considered to be impractical. 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| subjects | Antennas Antibodies, Immobilized - chemistry Antibodies, Immobilized - immunology Antigens - analysis Antigens - immunology Biosensing Techniques - instrumentation Biosensing Techniques - methods Biosensors Channels Electrodes Flexible electronics Food Quality Gold - chemistry ink-jet printing Metal Nanoparticles - chemistry micro-monopole antenna Microfluidics paper-based microfluidics Polyethylenes Radio frequency Radio frequency identification Radio Frequency Identification Device radio-frequency identification (RFID) Radiofrequency identification self-assemble self-powered sensing Silver silver enhancement Substrates UHF wireless biosensor Wireless Technology |
| title | Self-Powered Wireless Affinity-Based Biosensor Based on Integration of Paper-Based Microfluidics and Self-Assembled RFID Antennas |
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