In vivo biodistribution of stable spherical and filamentous micelles probed by high-sensitivity SPECT

Understanding how nanoparticle properties such as size, morphology and rigidity influence their circulation time and biodistribution is essential for the development of nanomedicine therapies. Herein we assess the influence of morphology on cellular internalization, in vivo biodistribution and circu...

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Veröffentlicht in:	Biomaterials science 2016-08, Vol.4 (8), p.1202-1211
Hauptverfasser:	Jennings, L, Ivashchenko, O, Marsman, I J C, Laan, A C, Denkova, A G, Waton, G, Beekman, F J, Schosseler, F, Mendes, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Circulation Circulation Drug Carriers - metabolism Drug Stability Dynamical systems Dynamics Elongation HeLa Cells Humans Indium Radioisotopes Liver Liver - metabolism Mice Mice, Inbred C57BL Micelles Morphology Nanomedicine Nanoparticles - metabolism Nanostructure Polyethylene Glycols - metabolism Polystyrenes - metabolism Single Photon Emission Computed Tomography Computed Tomography Surface Properties Tissue Distribution
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