Biodegradable Mg-Cu alloy implants with antibacterial activity for the treatment of osteomyelitis: In vitro and in vivo evaluations

Abstract Treatment of chronic osteomyelitis (bone infection) remains a clinical challenge; in particular, it requires an implantable material with improved antibacterial activity. Here, we prepared biodegradable magnesium (Mg)-copper (Cu) alloys with different Cu contents (0.05, 0.1, and 0.25 wt%) a...

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Veröffentlicht in:	Biomaterials 2016-11, Vol.106, p.250-263
Hauptverfasser:	Li, Yang, Liu, Lina, Wan, Peng, Zhai, Zanjing, Mao, Zhenyang, Ouyang, Zhengxiao, Yu, Degang, Sun, Qi, Tan, Lili, Ren, Ling, Zhu, Zhenan, Hao, Yongqiang, Qu, Xinhua, Yang, Ke, Dai, Kerong
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorbable Implants ACTIVITY Advanced Basic Science Alloys - administration & dosage Alloys - chemistry Animals Anti-Bacterial Agents Antibacterial activity Antibacterial properties Assaying Bacteria Biocompatibility Biodegradable Biomedical materials Copper - administration & dosage Copper - chemistry COPPER MAGNESIUM ALLOYS CORROSION Dentistry Drug Implants - administration & dosage In vitro testing Magnesium - administration & dosage Magnesium - chemistry MAGNESIUM ALLOYS (50 TO 99 MG) Magnesium base alloys MECHANICAL PROPERTIES Methicillin-Resistant Staphylococcus aureus - drug effects Mg-Cu alloy MICRO ORGANISMS Osteomyelitis Osteomyelitis - drug therapy Osteomyelitis - pathology PROPERTIES Rabbits Staphylococcal Infections - drug therapy Staphylococcal Infections - pathology Staphylococcus Surgical implants Treatment Outcome
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