super(1)H and super(13)C NMR spectral assignment of N,N'-disubstituted thiourea and urea derivatives active against nitric oxide synthase

The super(1)H and super(13)C NMR resonances of seventeen N-alkyl and aryl-N'-[3-hydroxy-3-(2-nitro-5-substituted phenyl)propyl]-thioureas and ureas (1-17), and seventeen N-alkyl or aryl-N'-[3-(2-amino-5-substitutedphenyl)-3- hydroxypropyl]-thioureas and ureas (18-34), designed as NOS inhibitors, were assigned completely using the concerted application of one- and two-dimensional experiments (DEPT, HSQC and HMBC). NOESY studies confirm the preferred conformation of these compounds. The super(1)H and super(13)C NMR resonances of a series of N,N'-disubstituted thiourea and urea derivatives were completely and unequivocally assigned using the concerted application of one- and two-dimensional experiments (DEPT, HSQC and HMBC, both carbon and nitrogen). NOESY experiments have confirmed the preferred conformation of these molecules.