Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction

Abstract With the advent of induced pluripotent stem cells and directed differentiation techniques, it is now feasible to derive individual-specific cardiac cells for human heart tissue engineering. Here we report the generation of functional engineered human cardiac patches using human induced plur...

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Veröffentlicht in:	Biomaterials 2016-10, Vol.105, p.52-65
Hauptverfasser:	Wang, Qingjie, Yang, Hui, Bai, Aobing, Jiang, Wei, Li, Xiuya, Wang, Xinhong, Mao, Yishen, Lu, Chao, Qian, Ruizhe, Guo, Feng, Ding, Tianling, Chen, Haiyan, Chen, Sifeng, Zhang, Jianyi, Liu, Chen, Sun, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Advanced Basic Science Animals Cardiac patch Cardiomyocytes Cell Differentiation Cell Proliferation Cell-Free System Decellularized heart matrix Demand Dentistry Engineering human heart tissue Extracellular Matrix - chemistry Fibroblasts - cytology Fibroblasts - transplantation Heart Heart function Humans Induced pluripotent stem cells Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - transplantation Male Myocardial infarction Myocardial Infarction - pathology Myocardial Infarction - therapy Myocytes, Cardiac - cytology Myocytes, Cardiac - transplantation Organ Culture Techniques - instrumentation Organ Culture Techniques - methods Physiology Rats Rats, Sprague-Dawley Regenerative Surgical implants Tissue engineering Tissue Engineering - instrumentation Tissue Engineering - methods Tissue Scaffolds Treatment Outcome
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