Immunohistochemical expression of MDR1‐Pgp 170 in canine cutaneous and oral melanomas: pattern of expression and association with tumour location and phenotype
Canine melanoma (CMM) more commonly affects the oral mucosa and the cutis. CMM shares several features with human melanomas (HMM), included resistance to a broad variety of antineoplastic chemotherapy agents. P‐glycoprotein 1 (Pgp) expression is a well‐recognized feature of multi‐drug resistance and...
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| Veröffentlicht in: | Veterinary & comparative oncology 2017-12, Vol.15 (4), p.1393-1402 |
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| creator | Finotello, R. Monné Rodriguez, J. M. Vilafranca, M. Altimira, J. Ramirez, G. A. Haines, A. Ressel, L. |
| description | Canine melanoma (CMM) more commonly affects the oral mucosa and the cutis. CMM shares several features with human melanomas (HMM), included resistance to a broad variety of antineoplastic chemotherapy agents. P‐glycoprotein 1 (Pgp) expression is a well‐recognized feature of multi‐drug resistance and the purpose of this study was to investigate its expression in treatment naïve CMM. We also investigated Pgp association with tumour location and histological features. Histology records of CMM were retrieved, including patients from 2012–2014. Twenty‐five cases of CMM were included in this study. Results revealed that Pgp is expressed in CMM and oral tumours were more likely to have a membranous Pgp expression (100%) than cutaneous tumours (66.6%) (P = 0.010). Cytoplasmic and nuclear Pgp expression could also be identified. Results of this study bring useful data that help in understanding one of the possible mechanisms responsible of intrinsic chemotherapy resistance in canine CMM. |
| doi_str_mv | 10.1111/vco.12281 |
| format | Article |
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M. ; Vilafranca, M. ; Altimira, J. ; Ramirez, G. A. ; Haines, A. ; Ressel, L.</creator><creatorcontrib>Finotello, R. ; Monné Rodriguez, J. M. ; Vilafranca, M. ; Altimira, J. ; Ramirez, G. A. ; Haines, A. ; Ressel, L.</creatorcontrib><description>Canine melanoma (CMM) more commonly affects the oral mucosa and the cutis. CMM shares several features with human melanomas (HMM), included resistance to a broad variety of antineoplastic chemotherapy agents. P‐glycoprotein 1 (Pgp) expression is a well‐recognized feature of multi‐drug resistance and the purpose of this study was to investigate its expression in treatment naïve CMM. We also investigated Pgp association with tumour location and histological features. Histology records of CMM were retrieved, including patients from 2012–2014. Twenty‐five cases of CMM were included in this study. Results revealed that Pgp is expressed in CMM and oral tumours were more likely to have a membranous Pgp expression (100%) than cutaneous tumours (66.6%) (P = 0.010). Cytoplasmic and nuclear Pgp expression could also be identified. Results of this study bring useful data that help in understanding one of the possible mechanisms responsible of intrinsic chemotherapy resistance in canine CMM.</description><identifier>ISSN: 1476-5810</identifier><identifier>EISSN: 1476-5829</identifier><identifier>DOI: 10.1111/vco.12281</identifier><identifier>PMID: 27779366</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism ; canine cutaneous melanoma ; canine oral melanoma ; Dog Diseases - metabolism ; Dog Diseases - pathology ; Dogs ; Female ; Male ; MDR1 ; Melanoma - metabolism ; Melanoma - pathology ; Melanoma - veterinary ; Mouth Neoplasms - metabolism ; Mouth Neoplasms - pathology ; Mouth Neoplasms - veterinary ; Pgp170 ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology ; Skin Neoplasms - veterinary</subject><ispartof>Veterinary & comparative oncology, 2017-12, Vol.15 (4), p.1393-1402</ispartof><rights>2016 John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3251-539da75f9c372353662d15f66c3a92b82625a4871cc9e0271b32e8adaea5e29e3</citedby><cites>FETCH-LOGICAL-c3251-539da75f9c372353662d15f66c3a92b82625a4871cc9e0271b32e8adaea5e29e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvco.12281$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvco.12281$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27779366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Finotello, R.</creatorcontrib><creatorcontrib>Monné Rodriguez, J. M.</creatorcontrib><creatorcontrib>Vilafranca, M.</creatorcontrib><creatorcontrib>Altimira, J.</creatorcontrib><creatorcontrib>Ramirez, G. A.</creatorcontrib><creatorcontrib>Haines, A.</creatorcontrib><creatorcontrib>Ressel, L.</creatorcontrib><title>Immunohistochemical expression of MDR1‐Pgp 170 in canine cutaneous and oral melanomas: pattern of expression and association with tumour location and phenotype</title><title>Veterinary & comparative oncology</title><addtitle>Vet Comp Oncol</addtitle><description>Canine melanoma (CMM) more commonly affects the oral mucosa and the cutis. CMM shares several features with human melanomas (HMM), included resistance to a broad variety of antineoplastic chemotherapy agents. P‐glycoprotein 1 (Pgp) expression is a well‐recognized feature of multi‐drug resistance and the purpose of this study was to investigate its expression in treatment naïve CMM. We also investigated Pgp association with tumour location and histological features. Histology records of CMM were retrieved, including patients from 2012–2014. Twenty‐five cases of CMM were included in this study. Results revealed that Pgp is expressed in CMM and oral tumours were more likely to have a membranous Pgp expression (100%) than cutaneous tumours (66.6%) (P = 0.010). Cytoplasmic and nuclear Pgp expression could also be identified. Results of this study bring useful data that help in understanding one of the possible mechanisms responsible of intrinsic chemotherapy resistance in canine CMM.</description><subject>Animals</subject><subject>ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism</subject><subject>canine cutaneous melanoma</subject><subject>canine oral melanoma</subject><subject>Dog Diseases - metabolism</subject><subject>Dog Diseases - pathology</subject><subject>Dogs</subject><subject>Female</subject><subject>Male</subject><subject>MDR1</subject><subject>Melanoma - metabolism</subject><subject>Melanoma - pathology</subject><subject>Melanoma - veterinary</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - veterinary</subject><subject>Pgp170</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - veterinary</subject><issn>1476-5810</issn><issn>1476-5829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAURi0Eoj-w4AWQl7CYNr4exwk7NG2hUqsiBGyjO84NYxTbwXZoZ8cj8Aq8Gk9CpmkrNtyNr63jI336GHshiiMxzfEPE44EQCUesX2x1OVCVVA_fthFsccOUvpWFABLCU_ZHmita1mW--z3uXOjDxubcjAbctZgz-lmiJSSDZ6Hjl-efBR_fv768HXgQhfcem7QW0_cjBk9hTFx9C0PcfrpqEcfHKY3fMCcKd4a_vHtSEwpGIt5d7-2ecPz6MIYeR_M_LiDhg35kLcDPWNPOuwTPb87D9nns9NPq_eLi6t356u3FwsjQYmFknWLWnW1kRqkmsJBK1RXlkZiDesKSlC4rLQwpqYCtFhLoApbJFQENclD9mr2DjF8HynlxtlkqO_njI2opCqhECVM6OsZNTGkFKlrhmgdxm0jimbXSDM10tw2MrEv77Tj2lH7QN5XMAHHM3Bte9r-39R8WV3Nyr9Mvpjy</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Finotello, R.</creator><creator>Monné Rodriguez, J. M.</creator><creator>Vilafranca, M.</creator><creator>Altimira, J.</creator><creator>Ramirez, G. A.</creator><creator>Haines, A.</creator><creator>Ressel, L.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201712</creationdate><title>Immunohistochemical expression of MDR1‐Pgp 170 in canine cutaneous and oral melanomas: pattern of expression and association with tumour location and phenotype</title><author>Finotello, R. ; Monné Rodriguez, J. M. ; Vilafranca, M. ; Altimira, J. ; Ramirez, G. A. ; Haines, A. ; Ressel, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3251-539da75f9c372353662d15f66c3a92b82625a4871cc9e0271b32e8adaea5e29e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism</topic><topic>canine cutaneous melanoma</topic><topic>canine oral melanoma</topic><topic>Dog Diseases - metabolism</topic><topic>Dog Diseases - pathology</topic><topic>Dogs</topic><topic>Female</topic><topic>Male</topic><topic>MDR1</topic><topic>Melanoma - metabolism</topic><topic>Melanoma - pathology</topic><topic>Melanoma - veterinary</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mouth Neoplasms - veterinary</topic><topic>Pgp170</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Finotello, R.</creatorcontrib><creatorcontrib>Monné Rodriguez, J. M.</creatorcontrib><creatorcontrib>Vilafranca, M.</creatorcontrib><creatorcontrib>Altimira, J.</creatorcontrib><creatorcontrib>Ramirez, G. A.</creatorcontrib><creatorcontrib>Haines, A.</creatorcontrib><creatorcontrib>Ressel, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary & comparative oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Finotello, R.</au><au>Monné Rodriguez, J. M.</au><au>Vilafranca, M.</au><au>Altimira, J.</au><au>Ramirez, G. 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We also investigated Pgp association with tumour location and histological features. Histology records of CMM were retrieved, including patients from 2012–2014. Twenty‐five cases of CMM were included in this study. Results revealed that Pgp is expressed in CMM and oral tumours were more likely to have a membranous Pgp expression (100%) than cutaneous tumours (66.6%) (P = 0.010). Cytoplasmic and nuclear Pgp expression could also be identified. Results of this study bring useful data that help in understanding one of the possible mechanisms responsible of intrinsic chemotherapy resistance in canine CMM.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>27779366</pmid><doi>10.1111/vco.12281</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism canine cutaneous melanoma canine oral melanoma Dog Diseases - metabolism Dog Diseases - pathology Dogs Female Male MDR1 Melanoma - metabolism Melanoma - pathology Melanoma - veterinary Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Mouth Neoplasms - veterinary Pgp170 Skin Neoplasms - metabolism Skin Neoplasms - pathology Skin Neoplasms - veterinary |
| title | Immunohistochemical expression of MDR1‐Pgp 170 in canine cutaneous and oral melanomas: pattern of expression and association with tumour location and phenotype |
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