A pH-Responsive Hydrogel Based on a Tumor-Targeting Mesoporous Silica Nanocomposite for Sustained Cancer Labeling and Therapy

A facile strategy is presented to synthesize hyaluronic acid (HA) and a fluorescein isothiocyanate (FITC)‐conjugated mesoporous silica nanocomposite (MSN) with multiple functions of fluorescence, tumor‐cell targeting, pH‐triggered gelation, and enzyme‐responsive drug release. This injectable nanocom...

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Veröffentlicht in:	Macromolecular rapid communications. 2016-09, Vol.37 (18), p.1533-1539
Hauptverfasser:	Chen, Xin, Liu, Zhongning
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology biodegradable hydrogels Cancer Cell Line, Tumor Cell Survival - drug effects Dose-Response Relationship, Drug Doxorubicin - administration & dosage Doxorubicin - pharmacology Drug delivery systems Drugs Fluorescence Humans Hyaluronic acid Hyaluronic Acid - chemistry Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Hydrogel, Polyethylene Glycol Dimethacrylate - metabolism Hydrogels Hydrogen-Ion Concentration Isothiocyanates - chemistry mesoporous silica nanocomposites Nanocomposites Nanocomposites - chemistry Neoplasms - drug therapy Neoplasms - metabolism Particle Size pH responsiveness Porosity Silicon dioxide Silicon Dioxide - chemistry Structure-Activity Relationship Surface Properties sustained cancer labeling and therapy tumor-targeting Tumors
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