Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy
Abstract A novel phototheranostic platform based on tri -malonate derivative of fullerene C70 (TFC70 )/photosensitizer (Chlorin e6, Ce6) nanovesicles (FCNVs) has been developed for effective tumor imaging and treatment. The FCNVs were prepared from amphiphilic TFC70 -oligo ethylene glycol -Ce6 molec...
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| Veröffentlicht in: | Biomaterials 2016-10, Vol.103, p.75-85 |
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| creator | Guan, Mirong Ge, Jiechao Wu, Jingyi Zhang, Guoqiang Chen, Daiqin Zhang, Wei Zhang, Ying Zou, Toujun Zhen, Mingming Wang, Chunru Chu, Taiwei Hao, Xiaojuan Shu, Chunying |
| description | Abstract A novel phototheranostic platform based on tri -malonate derivative of fullerene C70 (TFC70 )/photosensitizer (Chlorin e6, Ce6) nanovesicles (FCNVs) has been developed for effective tumor imaging and treatment. The FCNVs were prepared from amphiphilic TFC70 -oligo ethylene glycol -Ce6 molecules. The developed FCNVs possessed the following advantages: (i) high loading efficiency of Ce6 (up to ∼57 wt%); (ii) efficient absorption in near-infrared light region; (iii) enhanced cellular uptake efficiency of Ce6 in vitro and in vivo ; (iv) good biocompatibility and total clearance out from the body. These unique properties suggest that the as-prepared FCNVs could be applied as an ideal theranostic agent for simultaneous imaging and photodynamic therapy of tumor. This finding may provide a good solution to highly efficient phototheranostic applications based on fullerene derivatives fabricated nanostructures. |
| doi_str_mv | 10.1016/j.biomaterials.2016.06.023 |
| format | Article |
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The FCNVs were prepared from amphiphilic TFC70 -oligo ethylene glycol -Ce6 molecules. The developed FCNVs possessed the following advantages: (i) high loading efficiency of Ce6 (up to ∼57 wt%); (ii) efficient absorption in near-infrared light region; (iii) enhanced cellular uptake efficiency of Ce6 in vitro and in vivo ; (iv) good biocompatibility and total clearance out from the body. These unique properties suggest that the as-prepared FCNVs could be applied as an ideal theranostic agent for simultaneous imaging and photodynamic therapy of tumor. This finding may provide a good solution to highly efficient phototheranostic applications based on fullerene derivatives fabricated nanostructures.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2016.06.023</identifier><identifier>PMID: 27376559</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>A549 Cells ; Absorption, Physicochemical ; Advanced Basic Science ; Animals ; Apoptosis - drug effects ; Apoptosis - radiation effects ; Biocompatibility ; Cellular ; Dentistry ; Derivatives ; Diffusion ; Female ; Fullerene ; Fullerenes ; Fullerenes - chemistry ; Humans ; Imaging ; Mice ; Mice, Inbred BALB C ; Nanocapsules - administration & dosage ; Nanocapsules - chemistry ; Nanocapsules - ultrastructure ; Nanostructure ; Nanovesicle ; Near infrared radiation ; Neoplasms, Experimental - chemistry ; Neoplasms, Experimental - drug therapy ; Neoplasms, Experimental - pathology ; Particle Size ; Photochemotherapy - methods ; Photosensitizer ; Photosensitizing Agents - administration & dosage ; Photosensitizing Agents - chemistry ; Phototheranostic ; Porphyrins - administration & dosage ; Porphyrins - chemistry ; Tissue Distribution ; Treatment Outcome ; Tumors</subject><ispartof>Biomaterials, 2016-10, Vol.103, p.75-85</ispartof><rights>The Author(s)</rights><rights>2016 The Author(s)</rights><rights>Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-ebf5023facfbd160dbd71f5296c2d6bd36aab693cd7514c7aabf3f8edb7abf123</citedby><cites>FETCH-LOGICAL-c553t-ebf5023facfbd160dbd71f5296c2d6bd36aab693cd7514c7aabf3f8edb7abf123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2016.06.023$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27376559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guan, Mirong</creatorcontrib><creatorcontrib>Ge, Jiechao</creatorcontrib><creatorcontrib>Wu, Jingyi</creatorcontrib><creatorcontrib>Zhang, Guoqiang</creatorcontrib><creatorcontrib>Chen, Daiqin</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Zou, Toujun</creatorcontrib><creatorcontrib>Zhen, Mingming</creatorcontrib><creatorcontrib>Wang, Chunru</creatorcontrib><creatorcontrib>Chu, Taiwei</creatorcontrib><creatorcontrib>Hao, Xiaojuan</creatorcontrib><creatorcontrib>Shu, Chunying</creatorcontrib><title>Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Abstract A novel phototheranostic platform based on tri -malonate derivative of fullerene C70 (TFC70 )/photosensitizer (Chlorin e6, Ce6) nanovesicles (FCNVs) has been developed for effective tumor imaging and treatment. The FCNVs were prepared from amphiphilic TFC70 -oligo ethylene glycol -Ce6 molecules. The developed FCNVs possessed the following advantages: (i) high loading efficiency of Ce6 (up to ∼57 wt%); (ii) efficient absorption in near-infrared light region; (iii) enhanced cellular uptake efficiency of Ce6 in vitro and in vivo ; (iv) good biocompatibility and total clearance out from the body. These unique properties suggest that the as-prepared FCNVs could be applied as an ideal theranostic agent for simultaneous imaging and photodynamic therapy of tumor. This finding may provide a good solution to highly efficient phototheranostic applications based on fullerene derivatives fabricated nanostructures.</description><subject>A549 Cells</subject><subject>Absorption, Physicochemical</subject><subject>Advanced Basic Science</subject><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - radiation effects</subject><subject>Biocompatibility</subject><subject>Cellular</subject><subject>Dentistry</subject><subject>Derivatives</subject><subject>Diffusion</subject><subject>Female</subject><subject>Fullerene</subject><subject>Fullerenes</subject><subject>Fullerenes - chemistry</subject><subject>Humans</subject><subject>Imaging</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nanocapsules - administration & dosage</subject><subject>Nanocapsules - chemistry</subject><subject>Nanocapsules - ultrastructure</subject><subject>Nanostructure</subject><subject>Nanovesicle</subject><subject>Near infrared radiation</subject><subject>Neoplasms, Experimental - chemistry</subject><subject>Neoplasms, Experimental - drug therapy</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Particle Size</subject><subject>Photochemotherapy - methods</subject><subject>Photosensitizer</subject><subject>Photosensitizing Agents - administration & dosage</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Phototheranostic</subject><subject>Porphyrins - administration & dosage</subject><subject>Porphyrins - chemistry</subject><subject>Tissue Distribution</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1vFDEMHSEQXQp_AUWcuMw2H5P54ICECgWkShyAc5RJHCZLJlmSTKvlR_Q3N9MtCHGqZCmx_Z4t-7mqXhG8JZi0Z7vtaMMsM0QrXdrSEtviYpQ9qjak7_qaD5g_rjaYNLQeWkJPqmcp7XDxcUOfVie0Y13L-bCpbi4W5yCCh7P9FHJI4JPN9jdE5KUPV5CscpCQTGiyPyZ3QGCMVRZ8RtJrVJIyytEBuqPnCWKhpWxVQtc2Twj8JL0CjfIyh4ikUsu8OJlt8MiUgFqzEd0R94fn1RNTZoIX9-9p9f3iw7fzT_Xll4-fz99d1opzlmsYDS_jGqnMqEmL9ag7YjgdWkV1O2rWSjm2A1O646RRXfEMMz3osSs_Qtlp9fpYdx_DrwVSFrNNCpyTHsKSBOkZL3trKH8AlJSdN13fFOibI1TFkFIEI_bRzjIeBMFilU7sxL_SiVU6gYtRVsgv7_ss4wz6L_WPVgXw_giAspgrC1GkVYeyWxtBZaGDfVift_-VUc56q6T7CQdIu7BEv3KISFRg8XU9ovWGSMsw7TrMbgGWzsxM</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Guan, Mirong</creator><creator>Ge, Jiechao</creator><creator>Wu, Jingyi</creator><creator>Zhang, Guoqiang</creator><creator>Chen, Daiqin</creator><creator>Zhang, Wei</creator><creator>Zhang, Ying</creator><creator>Zou, Toujun</creator><creator>Zhen, Mingming</creator><creator>Wang, Chunru</creator><creator>Chu, Taiwei</creator><creator>Hao, Xiaojuan</creator><creator>Shu, Chunying</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20161001</creationdate><title>Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy</title><author>Guan, Mirong ; Ge, Jiechao ; Wu, Jingyi ; Zhang, Guoqiang ; Chen, Daiqin ; Zhang, Wei ; Zhang, Ying ; Zou, Toujun ; Zhen, Mingming ; Wang, Chunru ; Chu, Taiwei ; Hao, Xiaojuan ; Shu, Chunying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c553t-ebf5023facfbd160dbd71f5296c2d6bd36aab693cd7514c7aabf3f8edb7abf123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>A549 Cells</topic><topic>Absorption, Physicochemical</topic><topic>Advanced Basic Science</topic><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - radiation effects</topic><topic>Biocompatibility</topic><topic>Cellular</topic><topic>Dentistry</topic><topic>Derivatives</topic><topic>Diffusion</topic><topic>Female</topic><topic>Fullerene</topic><topic>Fullerenes</topic><topic>Fullerenes - chemistry</topic><topic>Humans</topic><topic>Imaging</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Nanocapsules - administration & dosage</topic><topic>Nanocapsules - chemistry</topic><topic>Nanocapsules - ultrastructure</topic><topic>Nanostructure</topic><topic>Nanovesicle</topic><topic>Near infrared radiation</topic><topic>Neoplasms, Experimental - chemistry</topic><topic>Neoplasms, Experimental - drug therapy</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Particle Size</topic><topic>Photochemotherapy - methods</topic><topic>Photosensitizer</topic><topic>Photosensitizing Agents - administration & dosage</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Phototheranostic</topic><topic>Porphyrins - administration & dosage</topic><topic>Porphyrins - chemistry</topic><topic>Tissue Distribution</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guan, Mirong</creatorcontrib><creatorcontrib>Ge, Jiechao</creatorcontrib><creatorcontrib>Wu, Jingyi</creatorcontrib><creatorcontrib>Zhang, Guoqiang</creatorcontrib><creatorcontrib>Chen, Daiqin</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Zou, Toujun</creatorcontrib><creatorcontrib>Zhen, Mingming</creatorcontrib><creatorcontrib>Wang, Chunru</creatorcontrib><creatorcontrib>Chu, Taiwei</creatorcontrib><creatorcontrib>Hao, Xiaojuan</creatorcontrib><creatorcontrib>Shu, Chunying</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guan, Mirong</au><au>Ge, Jiechao</au><au>Wu, Jingyi</au><au>Zhang, Guoqiang</au><au>Chen, Daiqin</au><au>Zhang, Wei</au><au>Zhang, Ying</au><au>Zou, Toujun</au><au>Zhen, Mingming</au><au>Wang, Chunru</au><au>Chu, Taiwei</au><au>Hao, Xiaojuan</au><au>Shu, Chunying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>103</volume><spage>75</spage><epage>85</epage><pages>75-85</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Abstract A novel phototheranostic platform based on tri -malonate derivative of fullerene C70 (TFC70 )/photosensitizer (Chlorin e6, Ce6) nanovesicles (FCNVs) has been developed for effective tumor imaging and treatment. The FCNVs were prepared from amphiphilic TFC70 -oligo ethylene glycol -Ce6 molecules. The developed FCNVs possessed the following advantages: (i) high loading efficiency of Ce6 (up to ∼57 wt%); (ii) efficient absorption in near-infrared light region; (iii) enhanced cellular uptake efficiency of Ce6 in vitro and in vivo ; (iv) good biocompatibility and total clearance out from the body. These unique properties suggest that the as-prepared FCNVs could be applied as an ideal theranostic agent for simultaneous imaging and photodynamic therapy of tumor. This finding may provide a good solution to highly efficient phototheranostic applications based on fullerene derivatives fabricated nanostructures.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>27376559</pmid><doi>10.1016/j.biomaterials.2016.06.023</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | A549 Cells Absorption, Physicochemical Advanced Basic Science Animals Apoptosis - drug effects Apoptosis - radiation effects Biocompatibility Cellular Dentistry Derivatives Diffusion Female Fullerene Fullerenes Fullerenes - chemistry Humans Imaging Mice Mice, Inbred BALB C Nanocapsules - administration & dosage Nanocapsules - chemistry Nanocapsules - ultrastructure Nanostructure Nanovesicle Near infrared radiation Neoplasms, Experimental - chemistry Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Particle Size Photochemotherapy - methods Photosensitizer Photosensitizing Agents - administration & dosage Photosensitizing Agents - chemistry Phototheranostic Porphyrins - administration & dosage Porphyrins - chemistry Tissue Distribution Treatment Outcome Tumors |
| title | Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy |
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