Identification of a Novel SHP-2 Protein Tyrosine Phosphatase Inhibitor

The Src homology 2 (SH2) domain-containing phosphatase 2 (SHP-2) is a nonreceptor protein tyrosine phosphatase (PTP) involved in extracellular-regulated kinase (ERK) activation. Recent studies have shown that gain-of-function mutations in SHP-2 are associated with several diseases, including LEOPARD...

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Veröffentlicht in:	Bulletin of the Chemical Society of Japan 2014-03, Vol.87 (3), p.420-424
Hauptverfasser:	Ju, Anna, Seo, Huiyun, Kim, Heemun, Park, Byoung Chul, Park, Sung Goo, Kim, Jeong Hoon, Choi, Hyung-Kyoon, Min, Kyung Hoon, Cho, Sayeon
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Disorders Inhibitors Kinases Lead compounds Mutations Proteins Tyrosine
Online-Zugang:	Volltext
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