Nephrotoxicity in rabbits after long-term nandrolone decanoate administration

•Nephrotoxic effects of nandrolone decanoate on young rabbits.•Significant increase in serum urea and creatinine.•Hypereamia, fibrosis and focal inflammation in kidney tissue of high-dosed rabbits.•Increased telomerase activity in intramuscularly treated animals.•Tissue TBARS and GSH levels were sig...

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Veröffentlicht in:	Toxicology letters 2016-09, Vol.259, p.21-27
Hauptverfasser:	Tsitsimpikou, Christina, Vasilaki, Fotini, Tsarouhas, Konstantinos, Fragkiadaki, Persefoni, Tzardi, Maria, Goutzourelas, Nikolaos, Nepka, Charitini, Kalogeraki, Alexandra, Heretis, Ioannis, Epitropaki, Zoi, Kouretas, Dimitrios, Tsatsakis, Aristidis M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anabolic Agents - administration & dosage Anabolic Agents - toxicity Animals Biomarkers Creatinine Drug Administration Schedule Kidney Kidney Diseases - chemically induced Kidneys Male Markers Mathematical models Nandrolone Nandrolone - administration & dosage Nandrolone - analogs & derivatives Nandrolone - toxicity Oxidative stress Oxidative Stress - drug effects Rabbits Stresses Telomerase Toxicity Urea
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