Plant development regulated by cytokinin sinks
Morphogenetic signals control the patterning of multicellular organisms. Cytokinins are mobile signals that are perceived by subsets of plant cells. We found that the responses to cytokinin signaling during Arabidopsis development are constrained by the transporter PURINE PERMEASE 14 (PUP14). In our...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2016-09, Vol.353 (6303), p.1027-1030 |
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| creator | Zürcher, Evelyne Liu, Jingchun di Donato, Martin Geisler, Markus Müller, Bruno |
| description | Morphogenetic signals control the patterning of multicellular organisms. Cytokinins are mobile signals that are perceived by subsets of plant cells. We found that the responses to cytokinin signaling during Arabidopsis development are constrained by the transporter PURINE PERMEASE 14 (PUP14). In our experiments, the expression of PUP14 was inversely correlated to the cytokinin signaling readout. Loss of PUP14 function allowed ectopic cytokinin signaling accompanied by aberrant morphogenesis in embryos, roots, and the shoot apical meristem. PUP14 protein localized to the plasma membrane and imported bioactive cytokinins, thus depleting apoplastic cytokinin pools and inhibiting perception by plasma membrane-localized cytokinin sensors to create a sink for active ligands. We propose that the spatiotemporal cytokinin sink patterns established by PUP14 determine the cytokinin signaling landscape that shapes the morphogenesis of land plants. |
| doi_str_mv | 10.1126/science.aaf7254 |
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Cytokinins are mobile signals that are perceived by subsets of plant cells. We found that the responses to cytokinin signaling during Arabidopsis development are constrained by the transporter PURINE PERMEASE 14 (PUP14). In our experiments, the expression of PUP14 was inversely correlated to the cytokinin signaling readout. Loss of PUP14 function allowed ectopic cytokinin signaling accompanied by aberrant morphogenesis in embryos, roots, and the shoot apical meristem. PUP14 protein localized to the plasma membrane and imported bioactive cytokinins, thus depleting apoplastic cytokinin pools and inhibiting perception by plasma membrane-localized cytokinin sensors to create a sink for active ligands. 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We propose that the spatiotemporal cytokinin sink patterns established by PUP14 determine the cytokinin signaling landscape that shapes the morphogenesis of land plants.</description><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - growth & development</subject><subject>Arabidopsis - metabolism</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Biochemistry</subject><subject>Cell Membrane - enzymology</subject><subject>Cytokinins - metabolism</subject><subject>Depletion</subject><subject>Embryos</subject><subject>Land</subject><subject>Landscapes</subject><subject>Ligands</subject><subject>Meristem - growth & development</subject><subject>Meristem - metabolism</subject><subject>Morphogenesis</subject><subject>Nucleobase Transport Proteins - genetics</subject><subject>Nucleobase Transport Proteins - metabolism</subject><subject>Patterning</subject><subject>Perception</subject><subject>Plant biology</subject><subject>Plant growth</subject><subject>Plant Roots - genetics</subject><subject>Plant Roots - growth & development</subject><subject>Plant Roots - metabolism</subject><subject>Plant Shoots - genetics</subject><subject>Plant Shoots - growth & development</subject><subject>Plant Shoots - metabolism</subject><subject>Plants (organisms)</subject><subject>Signal Transduction</subject><subject>Transporter</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0DtPwzAQB3ALgWgpzEygSCwsae3ze0QVL6kSDDBHjuOgtHkUO0Hqt8eooQMTky3d787nP0KXBM8JAbEItnKtdXNjSgmcHaEpwZqnGjA9RlOMqUgVlnyCzkJYYxxrmp6iCUiJSRwwRfPX2rR9UrgvV3fbxsW7dx9DbXpXJPkusbu-21Rt1SahajfhHJ2Upg7uYjxn6P3h_m35lK5eHp-Xd6vUcmB9qnIlC2MYFUpjKyHneWktcCGEBA1OM5uruBwIYgwGDgKAcCB5qSlThtAZut3P3fruc3Chz5oqWFfHZV03hIwoyrnSsfNfNL6ECY_05g9dd4Nv40eiItEA1SyqxV5Z34XgXZltfdUYv8sIzn5Sz8bUszH12HE9zh3yxhUH_xtzBFd7sA595w91xiTBnFD6DXQWhgU</recordid><startdate>20160902</startdate><enddate>20160902</enddate><creator>Zürcher, Evelyne</creator><creator>Liu, Jingchun</creator><creator>di Donato, Martin</creator><creator>Geisler, Markus</creator><creator>Müller, Bruno</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20160902</creationdate><title>Plant development regulated by cytokinin sinks</title><author>Zürcher, Evelyne ; Liu, Jingchun ; di Donato, Martin ; Geisler, Markus ; Müller, Bruno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-8b87daa436890c72b5bfcc256667292e94cb8036261aa02526221521bf9348a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Arabidopsis - genetics</topic><topic>Arabidopsis - growth & development</topic><topic>Arabidopsis - metabolism</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Biochemistry</topic><topic>Cell Membrane - enzymology</topic><topic>Cytokinins - metabolism</topic><topic>Depletion</topic><topic>Embryos</topic><topic>Land</topic><topic>Landscapes</topic><topic>Ligands</topic><topic>Meristem - growth & development</topic><topic>Meristem - metabolism</topic><topic>Morphogenesis</topic><topic>Nucleobase Transport Proteins - genetics</topic><topic>Nucleobase Transport Proteins - metabolism</topic><topic>Patterning</topic><topic>Perception</topic><topic>Plant biology</topic><topic>Plant growth</topic><topic>Plant Roots - genetics</topic><topic>Plant Roots - growth & development</topic><topic>Plant Roots - metabolism</topic><topic>Plant Shoots - genetics</topic><topic>Plant Shoots - growth & development</topic><topic>Plant Shoots - metabolism</topic><topic>Plants (organisms)</topic><topic>Signal Transduction</topic><topic>Transporter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zürcher, Evelyne</creatorcontrib><creatorcontrib>Liu, Jingchun</creatorcontrib><creatorcontrib>di Donato, Martin</creatorcontrib><creatorcontrib>Geisler, Markus</creatorcontrib><creatorcontrib>Müller, Bruno</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zürcher, Evelyne</au><au>Liu, Jingchun</au><au>di Donato, Martin</au><au>Geisler, Markus</au><au>Müller, Bruno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plant development regulated by cytokinin sinks</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2016-09-02</date><risdate>2016</risdate><volume>353</volume><issue>6303</issue><spage>1027</spage><epage>1030</epage><pages>1027-1030</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Morphogenetic signals control the patterning of multicellular organisms. Cytokinins are mobile signals that are perceived by subsets of plant cells. We found that the responses to cytokinin signaling during Arabidopsis development are constrained by the transporter PURINE PERMEASE 14 (PUP14). In our experiments, the expression of PUP14 was inversely correlated to the cytokinin signaling readout. Loss of PUP14 function allowed ectopic cytokinin signaling accompanied by aberrant morphogenesis in embryos, roots, and the shoot apical meristem. PUP14 protein localized to the plasma membrane and imported bioactive cytokinins, thus depleting apoplastic cytokinin pools and inhibiting perception by plasma membrane-localized cytokinin sensors to create a sink for active ligands. 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| subjects | Arabidopsis - genetics Arabidopsis - growth & development Arabidopsis - metabolism Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Biochemistry Cell Membrane - enzymology Cytokinins - metabolism Depletion Embryos Land Landscapes Ligands Meristem - growth & development Meristem - metabolism Morphogenesis Nucleobase Transport Proteins - genetics Nucleobase Transport Proteins - metabolism Patterning Perception Plant biology Plant growth Plant Roots - genetics Plant Roots - growth & development Plant Roots - metabolism Plant Shoots - genetics Plant Shoots - growth & development Plant Shoots - metabolism Plants (organisms) Signal Transduction Transporter |
| title | Plant development regulated by cytokinin sinks |
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