Preliminary characterization of a murine model for 1-bromopropane neurotoxicity: Role of cytochrome P450

•Inhibition of P450s enabled mice to survive after 1-BP exposure at a lethal level.•Hepatotoxicity of 1-BP was significantly reduced by inhibition of P450s.•The present model is the first to show 1-BP-induced decrease in brain weight in mice.•The present model is the first to show 1-BP-induced incre...

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Veröffentlicht in:	Toxicology letters 2016-09, Vol.258, p.249-258
Hauptverfasser:	Zong, Cai, Garner, C. Edwin, Huang, Chinyen, Zhang, Xiao, Zhang, Lingyi, Chang, Jie, Toyokuni, Shinya, Ito, Hidenori, Kato, Masashi, Sakurai, Toshihiro, Ichihara, Sahoko, Ichihara, Gaku
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Aminobenzotriazole 1-Bromopropane Animals Atmosphere Exposure Chambers Brain Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cerebral Cortex - pathology Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - mortality Chemical and Drug Induced Liver Injury - prevention & control Conjugation Cytochrome P-450 Enzyme Inhibitors - administration & dosage Cytochrome P-450 Enzyme Inhibitors - therapeutic use Cytochrome P-450 Enzyme System - metabolism Cytochromes P450 Disease Models, Animal Dose-Response Relationship, Drug Exposure Glutathione Heat-Shock Proteins - agonists Heat-Shock Proteins - metabolism Hepatotoxicity Hydrocarbons, Brominated - administration & dosage Hydrocarbons, Brominated - toxicity Injections, Intraperitoneal Injections, Subcutaneous Liver - drug effects Liver - metabolism Liver - pathology Male Mice Mice, Inbred C57BL Murine model Nerve Tissue Proteins - agonists Nerve Tissue Proteins - metabolism Neurons - drug effects Neurons - metabolism Neurons - pathology Neurotoxicity Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - pathology Organ Size - drug effects P450 ran GTP-Binding Protein - agonists ran GTP-Binding Protein - metabolism Reduction Solvents - administration & dosage Solvents - toxicity Toxicity Triazoles - administration & dosage Triazoles - therapeutic use
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