Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

Intracellular delivery of messenger RNA (mRNA) has the potential to induce protein production for many therapeutic applications. Although lipid nanoparticles have shown considerable promise for the delivery of small interfering RNAs (siRNA), their utility as agents for mRNA delivery has only recentl...

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Veröffentlicht in:	Nano letters 2015-11, Vol.15 (11), p.7300-7306
Hauptverfasser:	Kauffman, Kevin J, Dorkin, J. Robert, Yang, Jung H, Heartlein, Michael W, DeRosa, Frank, Mir, Faryal F, Fenton, Owen S, Anderson, Daniel G
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Design optimization Design parameters Formulations Gene Transfer Techniques Humans In vivo methods and tests Lipids Lipids - administration & dosage Lipids - chemistry Liposomes - administration & dosage Liposomes - chemistry Liver - drug effects Nanoparticles - administration & dosage Nanoparticles - chemistry Nanostructure Phosphatidylethanolamines - administration & dosage Phosphatidylethanolamines - chemistry Polyethylene Glycols - chemistry Ribonucleic acids RNA, Messenger - administration & dosage RNA, Messenger - chemistry Screening Transfection
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