Integrated Functional and Washing Routing Optimization for Cross-Contamination Removal in Digital Microfluidic Biochips
Digital microfluidic biochips (DMFBs) are gaining increasing attention with promising applications for automating and miniaturizing laboratory procedures in biochemistry. In DMFBs, cross-contamination of droplets with different biomolecules is a major issue, which causes significant errors in bioass...
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| Veröffentlicht in: | IEEE transactions on computer-aided design of integrated circuits and systems 2016-08, Vol.35 (8), p.1283-1296 |
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| creator | Yao, Hailong Wang, Qin Shen, Yiren Ho, Tsung-Yi Cai, Yici |
| description | Digital microfluidic biochips (DMFBs) are gaining increasing attention with promising applications for automating and miniaturizing laboratory procedures in biochemistry. In DMFBs, cross-contamination of droplets with different biomolecules is a major issue, which causes significant errors in bioassays. Washing operations are introduced to clean the cross-contamination spots. However, existing works have oversimplified assumptions on the washing behavior, which either assume infinite washing capacity, or ignore the routing conflicts between functional and washing droplets. This paper proposes the first integrated functional and washing droplet routing flow, which considers practical issues including the finite washing capacity constraint, and the routing conflicts between functional and washing droplets. Washing droplets of different sizes are also proposed to wash the congested cross-contamination spots. Effectiveness of the proposed method is validated by real-life biochemical applications. |
| doi_str_mv | 10.1109/TCAD.2015.2504397 |
| format | Article |
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Effectiveness of the proposed method is validated by real-life biochemical applications.</description><subject>Biochemistry</subject><subject>Biochips</subject><subject>Contamination</subject><subject>Cross-contamination</subject><subject>Digital</subject><subject>digital microfluidic biochips (DMFBs)</subject><subject>droplet routing</subject><subject>Droplets</subject><subject>Electrodes</subject><subject>Electronic mail</subject><subject>Indium tin oxide</subject><subject>Mathematical analysis</subject><subject>Microfluidics</subject><subject>Routing</subject><subject>Spots</subject><subject>Timing</subject><subject>Washing</subject><subject>washing capacity constraint</subject><subject>Yttrium</subject><issn>0278-0070</issn><issn>1937-4151</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><recordid>eNpdkU9P3DAQxa0KpC7QD1D1EolLL9mO_8XxkYZCkUBICNRj5I3txSixF9spop8eR4t64DSj0W-e5s1D6CuGNcYgf9x3Z-drApivCQdGpfiEVlhSUTPM8QFaARFtDSDgMzpK6QkAM07kCr1c-Wy2UWWjq4vZD9kFr8ZKeV39UenR-W11F-a81NtddpP7pxaksiFWXQwp1V3wWU3O7-d3Zgp_i4Dz1bnbulzaGzfEYMfZaTdUP10YHt0unaBDq8ZkvrzXY_Rw8eu--11f315edWfX9UBJk-t2IyQDzqnVnGhtytlWE0mAyuJVMU2x2UBLbKNsq_kG1IbJtmGCC2ixHegx-r7X3cXwPJuU-8mlwYyj8ibMqcct5UW-Yaygpx_QpzDH8o2FAg5SSkEKhffUsLiPxva76CYVX3sM_RJFv0TRL1H071GUnW_7HWeM-c8LSmUjCX0DWqWFkw</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Yao, Hailong</creator><creator>Wang, Qin</creator><creator>Shen, Yiren</creator><creator>Ho, Tsung-Yi</creator><creator>Cai, Yici</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. 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| identifier | ISSN: 0278-0070 |
| ispartof | IEEE transactions on computer-aided design of integrated circuits and systems, 2016-08, Vol.35 (8), p.1283-1296 |
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| source | IEEE Electronic Library (IEL) |
| subjects | Biochemistry Biochips Contamination Cross-contamination Digital digital microfluidic biochips (DMFBs) droplet routing Droplets Electrodes Electronic mail Indium tin oxide Mathematical analysis Microfluidics Routing Spots Timing Washing washing capacity constraint Yttrium |
| title | Integrated Functional and Washing Routing Optimization for Cross-Contamination Removal in Digital Microfluidic Biochips |
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