Potent oxazoline analog of apratoxin C: Synthesis, biological evaluation, and conformational analysis

ABSTRACT In this research, the synthesis, biological evaluation, and conformational analysis of an apratoxin C oxazoline analog (3) have been demonstrated. The preparation of synthetic key intermediate 9 was achieved using an improved strategy that involves commercially available 3‐methylglutaric an...

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Veröffentlicht in:	Biopolymers 2016-07, Vol.106 (4), p.404-414
Hauptverfasser:	Yoshida, Masahito, Onda, Yuichi, Masuda, Yuichi, Doi, Takayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Anhydrides apratoxin Biopolymers Cell Survival - drug effects Conformational analysis Coupling cyclodepsipeptide Cytotoxins - chemical synthesis Cytotoxins - chemistry Cytotoxins - pharmacology Depsipeptides - chemical synthesis Depsipeptides - chemistry Depsipeptides - pharmacology Formations HeLa Cells Humans natural product Precursors Strategy Synthesis total synthesis
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