Disposition kinetics of a dipeptide ester prodrug of acyclovir and its metabolites following intravenous and oral administrations in rat

The objective of this work was to study the disposition kinetics of valine-valine-acyclovir (VVACV), a dipeptide ester prodrug of acyclovir following intravenous and oral administrations in rat. A validated LC-MS/MS analytical method was developed for the analysis VVACV, Valine-Acyclovir (VACV), and...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Clinical research and regulatory affairs 2009-09, Vol.26 (3), p.65-72
Hauptverfasser:	Talluri, Ravi S., Gaudana, Ripal, Hariharan, Sudharshan, Jain, Ritesh, Mitra, Ashim K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir dipeptide metabolism pharmacokinetics prodrugs renal excretion
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!