Transmission dynamics of two dengue serotypes with vaccination scenarios
•We consider a mathematical model with two viral strains and temporary cross-immunity with one vector mosquito population.•We study the impact of different vaccination strategies from the efficacy values of the vaccine, the transmission intensity and cross immunity periods.•We have varied the cross...
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| Veröffentlicht in: | Mathematical biosciences 2017-05, Vol.287, p.54-71 |
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| creator | Morales, NL González Núñez-López, M Ramos-Castañeda, J Velasco-Hernández, JX |
| description | •We consider a mathematical model with two viral strains and temporary cross-immunity with one vector mosquito population.•We study the impact of different vaccination strategies from the efficacy values of the vaccine, the transmission intensity and cross immunity periods.•We have varied the cross immunity periods (180 and 270 days) of both serotypes to study the effect of this parameter on the asymptotic dynamic of our model.•Results suggest that vaccination scenarios will not only reduce disease incidence but will also modify the transmission dynamics.
In this work we present a mathematical model that incorporates two Dengue serotypes. The model has been constructed to study both the epidemiological trends of the disease and conditions that allow coexistence in competing strains under vaccination. We consider two viral strains and temporary cross-immunity with one vector mosquito population. Results suggest that vaccination scenarios will not only reduce disease incidence but will also modify the transmission dynamics. Indeed, vaccination and cross immunity period are seen to decrease the frequency and magnitude of outbreaks but in a differentiated manner with specific effects depending upon the interaction vaccine and strain type. |
| doi_str_mv | 10.1016/j.mbs.2016.10.001 |
| format | Article |
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In this work we present a mathematical model that incorporates two Dengue serotypes. The model has been constructed to study both the epidemiological trends of the disease and conditions that allow coexistence in competing strains under vaccination. We consider two viral strains and temporary cross-immunity with one vector mosquito population. Results suggest that vaccination scenarios will not only reduce disease incidence but will also modify the transmission dynamics. Indeed, vaccination and cross immunity period are seen to decrease the frequency and magnitude of outbreaks but in a differentiated manner with specific effects depending upon the interaction vaccine and strain type.</description><identifier>ISSN: 0025-5564</identifier><identifier>EISSN: 1879-3134</identifier><identifier>DOI: 10.1016/j.mbs.2016.10.001</identifier><identifier>PMID: 27773682</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Aquatic insects ; Coexistence ; Dengue ; Dengue - immunology ; Dengue - prevention & control ; Dengue - transmission ; Dengue fever ; Dengue Vaccines ; Dengue Virus - immunology ; Disease transmission ; Epidemiology ; Humans ; Immunity ; Immunization ; Mathematical models ; Models, Theoretical ; Mosquito Vectors ; Outbreaks ; Serogroup ; Serotypes ; Studies ; Vaccination ; Vaccine effects ; Vector-borne diseases ; Viral diseases</subject><ispartof>Mathematical biosciences, 2017-05, Vol.287, p.54-71</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. May 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-ba8d0a1f3b98c26d59b300edcf29451da52fe2f2de99f4a2218349e17d300f713</citedby><cites>FETCH-LOGICAL-c381t-ba8d0a1f3b98c26d59b300edcf29451da52fe2f2de99f4a2218349e17d300f713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mbs.2016.10.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27773682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morales, NL González</creatorcontrib><creatorcontrib>Núñez-López, M</creatorcontrib><creatorcontrib>Ramos-Castañeda, J</creatorcontrib><creatorcontrib>Velasco-Hernández, JX</creatorcontrib><title>Transmission dynamics of two dengue serotypes with vaccination scenarios</title><title>Mathematical biosciences</title><addtitle>Math Biosci</addtitle><description>•We consider a mathematical model with two viral strains and temporary cross-immunity with one vector mosquito population.•We study the impact of different vaccination strategies from the efficacy values of the vaccine, the transmission intensity and cross immunity periods.•We have varied the cross immunity periods (180 and 270 days) of both serotypes to study the effect of this parameter on the asymptotic dynamic of our model.•Results suggest that vaccination scenarios will not only reduce disease incidence but will also modify the transmission dynamics.
In this work we present a mathematical model that incorporates two Dengue serotypes. The model has been constructed to study both the epidemiological trends of the disease and conditions that allow coexistence in competing strains under vaccination. We consider two viral strains and temporary cross-immunity with one vector mosquito population. Results suggest that vaccination scenarios will not only reduce disease incidence but will also modify the transmission dynamics. Indeed, vaccination and cross immunity period are seen to decrease the frequency and magnitude of outbreaks but in a differentiated manner with specific effects depending upon the interaction vaccine and strain type.</description><subject>Animals</subject><subject>Aquatic insects</subject><subject>Coexistence</subject><subject>Dengue</subject><subject>Dengue - immunology</subject><subject>Dengue - prevention & control</subject><subject>Dengue - transmission</subject><subject>Dengue fever</subject><subject>Dengue Vaccines</subject><subject>Dengue Virus - immunology</subject><subject>Disease transmission</subject><subject>Epidemiology</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunization</subject><subject>Mathematical models</subject><subject>Models, Theoretical</subject><subject>Mosquito Vectors</subject><subject>Outbreaks</subject><subject>Serogroup</subject><subject>Serotypes</subject><subject>Studies</subject><subject>Vaccination</subject><subject>Vaccine effects</subject><subject>Vector-borne diseases</subject><subject>Viral diseases</subject><issn>0025-5564</issn><issn>1879-3134</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EotvCA3BBkbhwyeKx48QRJ1RBi1SJSzlbjj0Grzb24kla7dvj1RYOHDiNx_r-X6OPsTfAt8Ch_7DbzhNtRX3Wfcs5PGMb0MPYSpDdc7bhXKhWqb67YJdEuwoMAP1LdiGGYZC9Fht2e19sojkSxZwaf0x2jo6aHJrlMTce048VG8KSl-MBqXmMy8_mwToXk11OCXKYbImZXrEXwe4JXz_NK_b9y-f769v27tvN1-tPd62TGpZ2stpzC0FOo3ai92qcJOfoXRBjp8BbJQKKIDyOY-isEKBlNyIMvmJhAHnF3p97DyX_WpEWU493uN_bhHklU3mlpB67vqLv_kF3eS2pXmcEV4PWIDivFJwpVzJRwWAOJc62HA1wc9JsdqZqNifNp69qsWbePjWv04z-b-KP1wp8PANYVTxELIZcxOTQx4JuMT7H_9T_BoAtjUY</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Morales, NL González</creator><creator>Núñez-López, M</creator><creator>Ramos-Castañeda, J</creator><creator>Velasco-Hernández, JX</creator><general>Elsevier Inc</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7SN</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201705</creationdate><title>Transmission dynamics of two dengue serotypes with vaccination scenarios</title><author>Morales, NL González ; Núñez-López, M ; Ramos-Castañeda, J ; Velasco-Hernández, JX</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-ba8d0a1f3b98c26d59b300edcf29451da52fe2f2de99f4a2218349e17d300f713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Aquatic insects</topic><topic>Coexistence</topic><topic>Dengue</topic><topic>Dengue - immunology</topic><topic>Dengue - prevention & control</topic><topic>Dengue - transmission</topic><topic>Dengue fever</topic><topic>Dengue Vaccines</topic><topic>Dengue Virus - immunology</topic><topic>Disease transmission</topic><topic>Epidemiology</topic><topic>Humans</topic><topic>Immunity</topic><topic>Immunization</topic><topic>Mathematical models</topic><topic>Models, Theoretical</topic><topic>Mosquito Vectors</topic><topic>Outbreaks</topic><topic>Serogroup</topic><topic>Serotypes</topic><topic>Studies</topic><topic>Vaccination</topic><topic>Vaccine effects</topic><topic>Vector-borne diseases</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morales, NL González</creatorcontrib><creatorcontrib>Núñez-López, M</creatorcontrib><creatorcontrib>Ramos-Castañeda, J</creatorcontrib><creatorcontrib>Velasco-Hernández, JX</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ecology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Mathematical biosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morales, NL González</au><au>Núñez-López, M</au><au>Ramos-Castañeda, J</au><au>Velasco-Hernández, JX</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmission dynamics of two dengue serotypes with vaccination scenarios</atitle><jtitle>Mathematical biosciences</jtitle><addtitle>Math Biosci</addtitle><date>2017-05</date><risdate>2017</risdate><volume>287</volume><spage>54</spage><epage>71</epage><pages>54-71</pages><issn>0025-5564</issn><eissn>1879-3134</eissn><abstract>•We consider a mathematical model with two viral strains and temporary cross-immunity with one vector mosquito population.•We study the impact of different vaccination strategies from the efficacy values of the vaccine, the transmission intensity and cross immunity periods.•We have varied the cross immunity periods (180 and 270 days) of both serotypes to study the effect of this parameter on the asymptotic dynamic of our model.•Results suggest that vaccination scenarios will not only reduce disease incidence but will also modify the transmission dynamics.
In this work we present a mathematical model that incorporates two Dengue serotypes. The model has been constructed to study both the epidemiological trends of the disease and conditions that allow coexistence in competing strains under vaccination. We consider two viral strains and temporary cross-immunity with one vector mosquito population. Results suggest that vaccination scenarios will not only reduce disease incidence but will also modify the transmission dynamics. Indeed, vaccination and cross immunity period are seen to decrease the frequency and magnitude of outbreaks but in a differentiated manner with specific effects depending upon the interaction vaccine and strain type.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27773682</pmid><doi>10.1016/j.mbs.2016.10.001</doi><tpages>18</tpages></addata></record> |
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| subjects | Animals Aquatic insects Coexistence Dengue Dengue - immunology Dengue - prevention & control Dengue - transmission Dengue fever Dengue Vaccines Dengue Virus - immunology Disease transmission Epidemiology Humans Immunity Immunization Mathematical models Models, Theoretical Mosquito Vectors Outbreaks Serogroup Serotypes Studies Vaccination Vaccine effects Vector-borne diseases Viral diseases |
| title | Transmission dynamics of two dengue serotypes with vaccination scenarios |
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