Structure of the EndoMS-DNA Complex as Mismatch Restriction Endonuclease

Archaeal NucS nuclease was thought to degrade the single-stranded region of branched DNA, which contains flapped and splayed DNA. However, recent findings indicated that EndoMS, the orthologous enzyme of NucS, specifically cleaves double-stranded DNA (dsDNA) containing mismatched bases. In this stud...

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Veröffentlicht in:	Structure (London) 2016-11, Vol.24 (11), p.1960-1971
Hauptverfasser:	Nakae, Setsu, Hijikata, Atsushi, Tsuji, Toshiyuki, Yonezawa, Kouki, Kouyama, Ken-ichi, Mayanagi, Kouta, Ishino, Sonoko, Ishino, Yoshizumi, Shirai, Tsuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Archaeal Proteins - chemistry Archaeal Proteins - metabolism Binding Sites DNA metabolism DNA Mismatch Repair DNA repair DNA, Archaeal - chemistry DNA, Archaeal - metabolism DNA, Single-Stranded - chemistry DNA, Single-Stranded - metabolism Endodeoxyribonucleases - chemistry Endodeoxyribonucleases - metabolism Microscopy, Electron Models, Molecular Protein Binding Protein Conformation protein modeling protein-protein interaction Pyrococcus abyssi - chemistry Pyrococcus abyssi - enzymology structural bioinformatics
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