The Third Signal Cytokine Interleukin 12 Rather Than Immune Checkpoint Inhibitors Contributes to the Functional Restoration of Hepatitis D Virus–Specific T Cells

Background. Hepatitis D virus (HDV) infection affects 15–20 million individuals worldwide and causes severely progressive hepatitis. It is unknown to what extent cellular immune responses contribute to liver disease and control of viral replication in HDV infection. Methods. Immune cell frequencies...

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Veröffentlicht in:	The Journal of infectious diseases 2017-01, Vol.215 (1), p.139-149
Hauptverfasser:	Schirdewahn, Thomas, Grabowski, Jan, Sekyere, Solomon Owusu, Bremer, Birgit, Wranke, Anika, Lunemann, Sebastian, Schlaphoff, Verena, Kirschner, Janina, Hardtke, Svenja, Manns, Michael Peter, Cornberg, Markus, Wedemeyer, Heiner, Suneetha, Pothakamuri Venkata
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology CD57 Antigens - immunology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - virology CTLA-4 Antigen - immunology Cytokines - biosynthesis Cytomegalovirus - immunology Female Hepatitis D, Chronic - immunology Hepatitis D, Chronic - virology Hepatitis Delta Virus - chemistry Hepatitis Delta Virus - immunology Herpesvirus 4, Human - immunology Humans Interleukin-12 - administration & dosage Interleukin-12 - immunology Lymphocyte Activation Male Middle Aged PATHOGENESIS AND HOST RESPONSE Programmed Cell Death 1 Receptor - immunology T-Box Domain Proteins - metabolism Virus Replication
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