Mechanical dyssynchrony according to validated cut-off values using gated SPECT myocardial perfusion imaging
The aim of this study was to establish different degrees of mechanical dyssynchrony according to validated cut-off (CO) values of myocardial perfusion gated SPECT phase analysis parameters (SD, standard deviation; B, bandwidth; S, skewness; K, kurtosis). Using Emory Cardiac Toolbox™, we prospectivel...
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| Veröffentlicht in: | Journal of nuclear cardiology 2018-06, Vol.25 (3), p.999-1008 |
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| creator | Aguadé-Bruix, Santiago Romero-Farina, Guillermo Candell-Riera, Jaume Pizzi, María N. García-Dorado, David |
| description | The aim of this study was to establish different degrees of mechanical dyssynchrony according to validated cut-off (CO) values of myocardial perfusion gated SPECT phase analysis parameters (SD, standard deviation; B, bandwidth; S, skewness; K, kurtosis).
Using Emory Cardiac Toolbox™, we prospectively analyzed 408 patients (mean age 64.1 years, 26.7% female), divided into a control group of 150 normal subjects and a validation group of 258 patients (left bundle branch block: 17.8%, right bundle branch block: 8.9%. atrial fibrillation: 16.3%, coronary revascularization: 30%, dilated cardiomyopathy: 7.4%. valvulopathies: 2.7%, ischemic test: 45.3%) with ischemic and non-ischemic cardiac diseases, by means of phase analysis.
Agreement of CO values (SD > 18.4°; B > 51°; S ≤ 3.2; K ≤ 9.3) used to discriminate between normal subjects and patients was strong (c-statistic 0.9; 95% CI 0.98-0.99). Four degrees of dyssynchrony were found according to the number of abnormal phase parameters. All patients with mechanical and electrical criteria for cardiac resynchronization therapy (CCRT) (n: 82) had Grade 2 to 4 (two to four abnormal phase parameters). Agreement of CO values (SD > 40.2°; B > 132°; S ≤ 2.3; K ≤ 4.6) used to discriminate between patients with and without CCRT was strong (c-statistic 0.8; 95% CI 0.79-0.87) but 12% of patients with CCRT did not have any of these abnormal phase parameters.
The discriminatory capacity of gated SPECT phase analysis parameters between normal subjects and patients, and between patients with and without CCRT, is very good, making it possible to define different degrees of mechanical dyssynchrony. |
| doi_str_mv | 10.1007/s12350-016-0684-z |
| format | Article |
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Using Emory Cardiac Toolbox™, we prospectively analyzed 408 patients (mean age 64.1 years, 26.7% female), divided into a control group of 150 normal subjects and a validation group of 258 patients (left bundle branch block: 17.8%, right bundle branch block: 8.9%. atrial fibrillation: 16.3%, coronary revascularization: 30%, dilated cardiomyopathy: 7.4%. valvulopathies: 2.7%, ischemic test: 45.3%) with ischemic and non-ischemic cardiac diseases, by means of phase analysis.
Agreement of CO values (SD > 18.4°; B > 51°; S ≤ 3.2; K ≤ 9.3) used to discriminate between normal subjects and patients was strong (c-statistic 0.9; 95% CI 0.98-0.99). Four degrees of dyssynchrony were found according to the number of abnormal phase parameters. All patients with mechanical and electrical criteria for cardiac resynchronization therapy (CCRT) (n: 82) had Grade 2 to 4 (two to four abnormal phase parameters). Agreement of CO values (SD > 40.2°; B > 132°; S ≤ 2.3; K ≤ 4.6) used to discriminate between patients with and without CCRT was strong (c-statistic 0.8; 95% CI 0.79-0.87) but 12% of patients with CCRT did not have any of these abnormal phase parameters.
The discriminatory capacity of gated SPECT phase analysis parameters between normal subjects and patients, and between patients with and without CCRT, is very good, making it possible to define different degrees of mechanical dyssynchrony.</description><identifier>ISSN: 1071-3581</identifier><identifier>EISSN: 1532-6551</identifier><identifier>DOI: 10.1007/s12350-016-0684-z</identifier><identifier>PMID: 27804074</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Aged ; Arrhythmias, Cardiac - diagnostic imaging ; Arrhythmias, Cardiac - physiopathology ; cardiac resynchronization therapy ; Cardiology ; Cardiomyopathy, Dilated - complications ; Cardiomyopathy, Dilated - diagnostic imaging ; Cardiomyopathy, Dilated - physiopathology ; Coronary Disease - complications ; Coronary Disease - diagnostic imaging ; Coronary Disease - physiopathology ; dyssynchrony ; Electrocardiography ; Female ; Gated SPECT myocardial perfusion ; Heart Valve Diseases - complications ; Heart Valve Diseases - diagnostic imaging ; Heart Valve Diseases - physiopathology ; Humans ; Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Myocardial Perfusion Imaging ; Myocardial Revascularization ; Nuclear Medicine ; Original Article ; phase analysis ; Prospective Studies ; Radiology ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Journal of nuclear cardiology, 2018-06, Vol.25 (3), p.999-1008</ispartof><rights>2018 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved.</rights><rights>American Society of Nuclear Cardiology 2016</rights><rights>Journal of Nuclear Cardiology is a copyright of Springer, (2016). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-2f6600b16535ffa08fb951eb8aaa0912f9d532cce85616bcac3a0e0c80cd4e483</citedby><cites>FETCH-LOGICAL-c537t-2f6600b16535ffa08fb951eb8aaa0912f9d532cce85616bcac3a0e0c80cd4e483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12350-016-0684-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12350-016-0684-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27804074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aguadé-Bruix, Santiago</creatorcontrib><creatorcontrib>Romero-Farina, Guillermo</creatorcontrib><creatorcontrib>Candell-Riera, Jaume</creatorcontrib><creatorcontrib>Pizzi, María N.</creatorcontrib><creatorcontrib>García-Dorado, David</creatorcontrib><title>Mechanical dyssynchrony according to validated cut-off values using gated SPECT myocardial perfusion imaging</title><title>Journal of nuclear cardiology</title><addtitle>J. Nucl. Cardiol</addtitle><addtitle>J Nucl Cardiol</addtitle><description>The aim of this study was to establish different degrees of mechanical dyssynchrony according to validated cut-off (CO) values of myocardial perfusion gated SPECT phase analysis parameters (SD, standard deviation; B, bandwidth; S, skewness; K, kurtosis).
Using Emory Cardiac Toolbox™, we prospectively analyzed 408 patients (mean age 64.1 years, 26.7% female), divided into a control group of 150 normal subjects and a validation group of 258 patients (left bundle branch block: 17.8%, right bundle branch block: 8.9%. atrial fibrillation: 16.3%, coronary revascularization: 30%, dilated cardiomyopathy: 7.4%. valvulopathies: 2.7%, ischemic test: 45.3%) with ischemic and non-ischemic cardiac diseases, by means of phase analysis.
Agreement of CO values (SD > 18.4°; B > 51°; S ≤ 3.2; K ≤ 9.3) used to discriminate between normal subjects and patients was strong (c-statistic 0.9; 95% CI 0.98-0.99). Four degrees of dyssynchrony were found according to the number of abnormal phase parameters. All patients with mechanical and electrical criteria for cardiac resynchronization therapy (CCRT) (n: 82) had Grade 2 to 4 (two to four abnormal phase parameters). Agreement of CO values (SD > 40.2°; B > 132°; S ≤ 2.3; K ≤ 4.6) used to discriminate between patients with and without CCRT was strong (c-statistic 0.8; 95% CI 0.79-0.87) but 12% of patients with CCRT did not have any of these abnormal phase parameters.
The discriminatory capacity of gated SPECT phase analysis parameters between normal subjects and patients, and between patients with and without CCRT, is very good, making it possible to define different degrees of mechanical dyssynchrony.</description><subject>Aged</subject><subject>Arrhythmias, Cardiac - diagnostic imaging</subject><subject>Arrhythmias, Cardiac - physiopathology</subject><subject>cardiac resynchronization therapy</subject><subject>Cardiology</subject><subject>Cardiomyopathy, Dilated - complications</subject><subject>Cardiomyopathy, Dilated - diagnostic imaging</subject><subject>Cardiomyopathy, Dilated - physiopathology</subject><subject>Coronary Disease - complications</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - physiopathology</subject><subject>dyssynchrony</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Gated SPECT myocardial perfusion</subject><subject>Heart Valve Diseases - complications</subject><subject>Heart Valve Diseases - diagnostic imaging</subject><subject>Heart Valve Diseases - physiopathology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Myocardial Perfusion Imaging</subject><subject>Myocardial Revascularization</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>phase analysis</subject><subject>Prospective Studies</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>1071-3581</issn><issn>1532-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUFv1DAQhS1ERduFH8AFReLSi-k4jhNHnNCqUKQikChny5nYW1dZe7GTSumvxyGFSj30ZMvzveeZeYS8ZfCBATTniZVcAAVWU6hlRe9fkBMmeElrIdjLfIeGUS4kOyanKd0CQMvb9hU5LhsJFTTVCRm-GbzR3qEein5OafZ4E4OfC40YYu_8rhhDcacH1-vR9AVOIw3WLi-TScWUFmL3t_Tzx8X2utjPAXUWZr-DiTYDwRdur3cZfE2OrB6SefNwbsivzxfX20t69f3L1-2nK4qCNyMtbV0DdKwWXFirQdquFcx0UmsNLStt2-chEY0UNas71Mg1GEAJ2FemknxDzlbfQwy_c5uj2ruEZhi0N2FKikkuBGc8r2ND3j9Bb8MUfe5OlVBxYE3DFoqtFMaQUjRWHWKeKc6KgVqiUGsUKkehlijUfda8e3Ceur3p_yv-7T4D5QqkXPI7Ex-_fs714yoyeX93LosSOuPR9C4aHFUf3DPqP2h_qQM</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Aguadé-Bruix, Santiago</creator><creator>Romero-Farina, Guillermo</creator><creator>Candell-Riera, Jaume</creator><creator>Pizzi, María N.</creator><creator>García-Dorado, David</creator><general>Elsevier Inc</general><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20180601</creationdate><title>Mechanical dyssynchrony according to validated cut-off values using gated SPECT myocardial perfusion imaging</title><author>Aguadé-Bruix, Santiago ; 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Nucl. Cardiol</stitle><addtitle>J Nucl Cardiol</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>25</volume><issue>3</issue><spage>999</spage><epage>1008</epage><pages>999-1008</pages><issn>1071-3581</issn><eissn>1532-6551</eissn><abstract>The aim of this study was to establish different degrees of mechanical dyssynchrony according to validated cut-off (CO) values of myocardial perfusion gated SPECT phase analysis parameters (SD, standard deviation; B, bandwidth; S, skewness; K, kurtosis).
Using Emory Cardiac Toolbox™, we prospectively analyzed 408 patients (mean age 64.1 years, 26.7% female), divided into a control group of 150 normal subjects and a validation group of 258 patients (left bundle branch block: 17.8%, right bundle branch block: 8.9%. atrial fibrillation: 16.3%, coronary revascularization: 30%, dilated cardiomyopathy: 7.4%. valvulopathies: 2.7%, ischemic test: 45.3%) with ischemic and non-ischemic cardiac diseases, by means of phase analysis.
Agreement of CO values (SD > 18.4°; B > 51°; S ≤ 3.2; K ≤ 9.3) used to discriminate between normal subjects and patients was strong (c-statistic 0.9; 95% CI 0.98-0.99). Four degrees of dyssynchrony were found according to the number of abnormal phase parameters. All patients with mechanical and electrical criteria for cardiac resynchronization therapy (CCRT) (n: 82) had Grade 2 to 4 (two to four abnormal phase parameters). Agreement of CO values (SD > 40.2°; B > 132°; S ≤ 2.3; K ≤ 4.6) used to discriminate between patients with and without CCRT was strong (c-statistic 0.8; 95% CI 0.79-0.87) but 12% of patients with CCRT did not have any of these abnormal phase parameters.
The discriminatory capacity of gated SPECT phase analysis parameters between normal subjects and patients, and between patients with and without CCRT, is very good, making it possible to define different degrees of mechanical dyssynchrony.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>27804074</pmid><doi>10.1007/s12350-016-0684-z</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Arrhythmias, Cardiac - diagnostic imaging Arrhythmias, Cardiac - physiopathology cardiac resynchronization therapy Cardiology Cardiomyopathy, Dilated - complications Cardiomyopathy, Dilated - diagnostic imaging Cardiomyopathy, Dilated - physiopathology Coronary Disease - complications Coronary Disease - diagnostic imaging Coronary Disease - physiopathology dyssynchrony Electrocardiography Female Gated SPECT myocardial perfusion Heart Valve Diseases - complications Heart Valve Diseases - diagnostic imaging Heart Valve Diseases - physiopathology Humans Imaging Male Medicine Medicine & Public Health Middle Aged Myocardial Perfusion Imaging Myocardial Revascularization Nuclear Medicine Original Article phase analysis Prospective Studies Radiology Reproducibility of Results Sensitivity and Specificity Tomography, Emission-Computed, Single-Photon |
| title | Mechanical dyssynchrony according to validated cut-off values using gated SPECT myocardial perfusion imaging |
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