Homocysteine inhibits neural stem cells survival by inducing DNA interstrand cross-links via oxidative stress

•Hcy inhibits neural stem cells survival.•Hcy causes cell interstrand cross-links by oxidative stress and activates FA pathway.•Inhibiting Hcy-envoked reactive oxidative species generation could ameliorate DNA damage and cell survival. Elevated plasma levels of homocysteine have been implicated in n...

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Veröffentlicht in:	Neuroscience letters 2016-12, Vol.635, p.24-32
Hauptverfasser:	Wang, Dan, Chen, Yi-ming, Ruan, Miao-hua, Zhou, Ai-hua, Qian, Yan, Chen, Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Line Cell Survival DNA Damage Fanconi Anemia Complementation Group D2 Protein - metabolism Fanconi Anemia Complementation Group Proteins - metabolism Fanconi anemia pathway Homocysteine Homocysteine - metabolism Homocysteine - toxicity Interstrand cross-link Mice Neural stem cell Neural Stem Cells - cytology Neural Stem Cells - drug effects Oxidative stress Reactive Oxygen Species - metabolism Ubiquitination
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