Novel mechanism of modulation at a ligand-gated ion channel; action of 5-Cl-indole at the 5-HT3 A receptor

BACKGROUND AND PURPOSEThe 5-HT3 receptor is a prototypical member of the Cys-loop ligand-gated ion channel (LGIC) superfamily and an established therapeutic target. In addition to activation via the orthosteric site, receptor function can be modulated by allosteric ligands. We have investigated the...

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Veröffentlicht in:	British journal of pharmacology 2016-12, Vol.173 (24), p.3467-3479
Hauptverfasser:	Powell, Andrew D, Grafton, Gillian, Roberts, Alexander, Larkin, Shannon, O'Neill, Nathanael, Palandri, Josephine, Otvos, Reka, Cooper, Alison J, Ulens, Chris, Barnes, Nicholas M
Format:	Artikel
Sprache:	eng
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