Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3

Hepatocellular carcinoma (HCC) is the most commonly diagnosed malignancy of the liver, occurs frequently in the setting of chronic liver injury. Although multiple therapeutic approaches are available, the prognosis of patients with HCC remains poor. Dioscin is a natural steroid saponin that presents...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2016-11, Vol.23 (12), p.1329-1336
Hauptverfasser:	Zhang, Guangxian, Zeng, Xiancheng, Zhang, Ren, Liu, Juan, Zhang, Weici, Zhao, Yujun, Zhang, Xiaoyuan, Wu, Zhixue, Tan, Yuhui, Wu, Yingya, Du, Biaoyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - biosynthesis bcl-2-Associated X Protein - genetics Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Care and treatment Caspase 3 - biosynthesis Caspase 3 - genetics Cell Line, Tumor Dioscin Diosgenin - analogs & derivatives Diosgenin - pharmacology DNA damage DNA Fragmentation - drug effects Drug Screening Assays, Antitumor Fluorouracil - pharmacology Health aspects Hepatocellular carcinoma Hepatoma Humans Liver Neoplasms - drug therapy Liver Neoplasms - pathology Male Mice Mice, Nude Prevention Prognosis Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics Saponins Tetrazolium Salts Thiazoles Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics
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