Circulating Fibroblast Growth Factor-23 Level and Paraoxonase-1 Lactonase Activity in Chronic Hemodialysis Patients: Their Impact on the Incidence of Native AV Fistula Thrombosis
Thrombosis of native arteriovenous (AV) fistula is an important cause of complications in hemodialysis (HD) patients. The purpose of this study was to investigate the usefulness of measuring circulating fibroblast growth factor-23 (FGF-23) level and paraoxonase-1 (PON1) lactonase activity as potenti...
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| Veröffentlicht in: | Clinical and investigative medicine 2016-10, Vol.39 (5), p.E173-E181 |
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| creator | Zohny, Samir F El-Fattah, Mahmoud Abd Khan, Jalaluddin A |
| description | Thrombosis of native arteriovenous (AV) fistula is an important cause of complications in hemodialysis (HD) patients. The purpose of this study was to investigate the usefulness of measuring circulating fibroblast growth factor-23 (FGF-23) level and paraoxonase-1 (PON1) lactonase activity as potential predictors of native AV fistula thrombosis in chronic HD patients.
This study included 83 HD patients (48 with thrombosed and 35 with non-thrombosed native AV fistulas) and 38 healthy volunteers. Serum FGF-23 level was measured using the ELISA technique, while serum PON1 lactonase activity was measured spectrophotometrically using gamma-thiobutyrolactone as a substrate.
FGF-23 was significantly increased while PON1 lactonase was markedly decreased in both thrombosed and non-thrombosed HD patients compared with controls (P < 0.001). FGF-23 was elevated whereas PON1 lactonase was decreased in HD patients with thrombosed native AV fistulas compared with HD patients with non-thrombosed native AV fistulas (P = 0.001 and 0.002, respectively). A significant negative correlation was found between FGF-23 and PON1 lactonase in HD patients with thrombosed native AV fistulas (r = -0.342, P = 0.017).
This study shows a potential value of FGF-23 and PON1 lactonase as predictors of native AV fistula thrombosis in HD patients. |
| doi_str_mv | 10.25011/cim.v39i5.27149 |
| format | Article |
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This study included 83 HD patients (48 with thrombosed and 35 with non-thrombosed native AV fistulas) and 38 healthy volunteers. Serum FGF-23 level was measured using the ELISA technique, while serum PON1 lactonase activity was measured spectrophotometrically using gamma-thiobutyrolactone as a substrate.
FGF-23 was significantly increased while PON1 lactonase was markedly decreased in both thrombosed and non-thrombosed HD patients compared with controls (P < 0.001). FGF-23 was elevated whereas PON1 lactonase was decreased in HD patients with thrombosed native AV fistulas compared with HD patients with non-thrombosed native AV fistulas (P = 0.001 and 0.002, respectively). A significant negative correlation was found between FGF-23 and PON1 lactonase in HD patients with thrombosed native AV fistulas (r = -0.342, P = 0.017).
This study shows a potential value of FGF-23 and PON1 lactonase as predictors of native AV fistula thrombosis in HD patients.</description><identifier>ISSN: 1488-2353</identifier><identifier>EISSN: 1488-2353</identifier><identifier>DOI: 10.25011/cim.v39i5.27149</identifier><identifier>PMID: 27805900</identifier><identifier>CODEN: CNVMDL</identifier><language>eng</language><publisher>Canada: Canadian Society for Clinical Investigation</publisher><subject>4-Butyrolactone - analogs & derivatives ; 4-Butyrolactone - chemistry ; Acute coronary syndromes ; Adult ; Aged ; Arteriovenous Fistula - blood ; Arteriovenous Fistula - complications ; Arteriovenous Fistula - therapy ; Aryldialkylphosphatase - blood ; Atherosclerosis ; Biomarkers ; Cardiovascular disease ; Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Fibroblast Growth Factors - blood ; Fibroblasts ; Hemodialysis ; Humans ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - therapy ; Male ; Middle Aged ; Mortality ; Proteins ; Renal Dialysis ; Studies ; Thrombosis ; Thrombosis - blood ; Thrombosis - complications ; Thrombosis - therapy</subject><ispartof>Clinical and investigative medicine, 2016-10, Vol.39 (5), p.E173-E181</ispartof><rights>Copyright Canadian Society for Clinical Investigation Oct 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27805900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zohny, Samir F</creatorcontrib><creatorcontrib>El-Fattah, Mahmoud Abd</creatorcontrib><creatorcontrib>Khan, Jalaluddin A</creatorcontrib><title>Circulating Fibroblast Growth Factor-23 Level and Paraoxonase-1 Lactonase Activity in Chronic Hemodialysis Patients: Their Impact on the Incidence of Native AV Fistula Thrombosis</title><title>Clinical and investigative medicine</title><addtitle>Clin Invest Med</addtitle><description>Thrombosis of native arteriovenous (AV) fistula is an important cause of complications in hemodialysis (HD) patients. The purpose of this study was to investigate the usefulness of measuring circulating fibroblast growth factor-23 (FGF-23) level and paraoxonase-1 (PON1) lactonase activity as potential predictors of native AV fistula thrombosis in chronic HD patients.
This study included 83 HD patients (48 with thrombosed and 35 with non-thrombosed native AV fistulas) and 38 healthy volunteers. Serum FGF-23 level was measured using the ELISA technique, while serum PON1 lactonase activity was measured spectrophotometrically using gamma-thiobutyrolactone as a substrate.
FGF-23 was significantly increased while PON1 lactonase was markedly decreased in both thrombosed and non-thrombosed HD patients compared with controls (P < 0.001). FGF-23 was elevated whereas PON1 lactonase was decreased in HD patients with thrombosed native AV fistulas compared with HD patients with non-thrombosed native AV fistulas (P = 0.001 and 0.002, respectively). A significant negative correlation was found between FGF-23 and PON1 lactonase in HD patients with thrombosed native AV fistulas (r = -0.342, P = 0.017).
This study shows a potential value of FGF-23 and PON1 lactonase as predictors of native AV fistula thrombosis in HD patients.</description><subject>4-Butyrolactone - analogs & derivatives</subject><subject>4-Butyrolactone - chemistry</subject><subject>Acute coronary syndromes</subject><subject>Adult</subject><subject>Aged</subject><subject>Arteriovenous Fistula - blood</subject><subject>Arteriovenous Fistula - complications</subject><subject>Arteriovenous Fistula - therapy</subject><subject>Aryldialkylphosphatase - blood</subject><subject>Atherosclerosis</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fibroblast Growth Factors - blood</subject><subject>Fibroblasts</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Proteins</subject><subject>Renal Dialysis</subject><subject>Studies</subject><subject>Thrombosis</subject><subject>Thrombosis - blood</subject><subject>Thrombosis - complications</subject><subject>Thrombosis - therapy</subject><issn>1488-2353</issn><issn>1488-2353</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkU1vEzEURS1ERUthzwo9iQ2bCf6IOza7KiJtpIh20bIdeTxviKsZO9ielPwtfiFOWhBi5Sf53KMrXULeMTrjkjL2ybpxthPayRmv2Vy_IGdsrlTFhRQv_7lPyeuUHiilXF7oV-SU14pKTekZ-bVw0U6Dyc5_h6VrY2gHkzJcxfCYN7A0NodYHLDGHQ5gfAe3JprwM3iTsGKwPhCHGy5tdjuX9-A8LDYxeGfhGsfQOTPsk0slmB36nD7D3QZdhNW4LWEIHvIGYeWt69BbhNDD14LuivJb6ZRy6VciMYxtKJ435KQ3Q8K3z-85uV9-uVtcV-ubq9Xicl1ZrmiubG0ujKZ1a7BnqHrLWSvnErWgWnAlJWdMa2GsYR2rUSIqTk3f856XH1aLc_LxybuN4ceEKTejSxaHwXgMU2qYEkUiaiUL-uE_9CFM0Zd2B6qWcyGYKBR9omwMKUXsm210o4n7htHmuGdT9myOezbHPUvk_bN4akfs_gb-DCh-A4zfnbk</recordid><startdate>20161014</startdate><enddate>20161014</enddate><creator>Zohny, Samir F</creator><creator>El-Fattah, Mahmoud Abd</creator><creator>Khan, Jalaluddin A</creator><general>Canadian Society for Clinical Investigation</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M3G</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20161014</creationdate><title>Circulating Fibroblast Growth Factor-23 Level and Paraoxonase-1 Lactonase Activity in Chronic Hemodialysis Patients: Their Impact on the Incidence of Native AV Fistula Thrombosis</title><author>Zohny, Samir F ; El-Fattah, Mahmoud Abd ; Khan, Jalaluddin A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c280t-c7a6a907baef1e8fc21b545e930932855211993aca1d17e5ee820aff2f2211173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>4-Butyrolactone - analogs & derivatives</topic><topic>4-Butyrolactone - chemistry</topic><topic>Acute coronary syndromes</topic><topic>Adult</topic><topic>Aged</topic><topic>Arteriovenous Fistula - blood</topic><topic>Arteriovenous Fistula - complications</topic><topic>Arteriovenous Fistula - therapy</topic><topic>Aryldialkylphosphatase - blood</topic><topic>Atherosclerosis</topic><topic>Biomarkers</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fibroblast Growth Factors - blood</topic><topic>Fibroblasts</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Proteins</topic><topic>Renal Dialysis</topic><topic>Studies</topic><topic>Thrombosis</topic><topic>Thrombosis - blood</topic><topic>Thrombosis - complications</topic><topic>Thrombosis - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zohny, Samir F</creatorcontrib><creatorcontrib>El-Fattah, Mahmoud Abd</creatorcontrib><creatorcontrib>Khan, Jalaluddin A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>CBCA Reference & Current Events</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and investigative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zohny, Samir F</au><au>El-Fattah, Mahmoud Abd</au><au>Khan, Jalaluddin A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating Fibroblast Growth Factor-23 Level and Paraoxonase-1 Lactonase Activity in Chronic Hemodialysis Patients: Their Impact on the Incidence of Native AV Fistula Thrombosis</atitle><jtitle>Clinical and investigative medicine</jtitle><addtitle>Clin Invest Med</addtitle><date>2016-10-14</date><risdate>2016</risdate><volume>39</volume><issue>5</issue><spage>E173</spage><epage>E181</epage><pages>E173-E181</pages><issn>1488-2353</issn><eissn>1488-2353</eissn><coden>CNVMDL</coden><abstract>Thrombosis of native arteriovenous (AV) fistula is an important cause of complications in hemodialysis (HD) patients. The purpose of this study was to investigate the usefulness of measuring circulating fibroblast growth factor-23 (FGF-23) level and paraoxonase-1 (PON1) lactonase activity as potential predictors of native AV fistula thrombosis in chronic HD patients.
This study included 83 HD patients (48 with thrombosed and 35 with non-thrombosed native AV fistulas) and 38 healthy volunteers. Serum FGF-23 level was measured using the ELISA technique, while serum PON1 lactonase activity was measured spectrophotometrically using gamma-thiobutyrolactone as a substrate.
FGF-23 was significantly increased while PON1 lactonase was markedly decreased in both thrombosed and non-thrombosed HD patients compared with controls (P < 0.001). FGF-23 was elevated whereas PON1 lactonase was decreased in HD patients with thrombosed native AV fistulas compared with HD patients with non-thrombosed native AV fistulas (P = 0.001 and 0.002, respectively). A significant negative correlation was found between FGF-23 and PON1 lactonase in HD patients with thrombosed native AV fistulas (r = -0.342, P = 0.017).
This study shows a potential value of FGF-23 and PON1 lactonase as predictors of native AV fistula thrombosis in HD patients.</abstract><cop>Canada</cop><pub>Canadian Society for Clinical Investigation</pub><pmid>27805900</pmid><doi>10.25011/cim.v39i5.27149</doi></addata></record> |
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| subjects | 4-Butyrolactone - analogs & derivatives 4-Butyrolactone - chemistry Acute coronary syndromes Adult Aged Arteriovenous Fistula - blood Arteriovenous Fistula - complications Arteriovenous Fistula - therapy Aryldialkylphosphatase - blood Atherosclerosis Biomarkers Cardiovascular disease Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Fibroblast Growth Factors - blood Fibroblasts Hemodialysis Humans Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Kidney Failure, Chronic - therapy Male Middle Aged Mortality Proteins Renal Dialysis Studies Thrombosis Thrombosis - blood Thrombosis - complications Thrombosis - therapy |
| title | Circulating Fibroblast Growth Factor-23 Level and Paraoxonase-1 Lactonase Activity in Chronic Hemodialysis Patients: Their Impact on the Incidence of Native AV Fistula Thrombosis |
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