Massive Bitemporal Hemorrhages in Antineutrophil Cytoplasmic Autoantibodies Vasculitis
ANCA-associated small vessel vasculitides are systemic diseases characterized by inflammation and necrosis of small-sized blood vessels.1 They are characterized by the presence of antineutrophil cytoplasmic antibodies (ANCAs), which primarily target the kidney, lung, skin and peripheral nervous syst...
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description | ANCA-associated small vessel vasculitides are systemic diseases characterized by inflammation and necrosis of small-sized blood vessels.1 They are characterized by the presence of antineutrophil cytoplasmic antibodies (ANCAs), which primarily target the kidney, lung, skin and peripheral nervous system.2 In rare cases, they can affect the central nervous system (CNS) and cause cerebrovascular events.3 We present a patient with ANCA vasculitis who developed fatal massive bitemporal hemorrhages during the course of immunosuppressive therapy. [...]a recent meta-analysis has evaluated the specificity of elevated c-ANCA levels in the serum at 96.3% (CI [94.1-98.5]),4 which, combined with the high pretest probability of vasculitis (mononeuritis multiplex, acute renal failure, inflammatory anemia, multifocal brain infarcts), made a diagnosis of ANCA vasculitis highly probable even without a gold-standard pathological diagnosis. Figure 1 Axial view of a head CT showing massive bitemporal haemorrhages with significant mass effect. |
doi_str_mv | 10.1017/cjn.2016.401 |
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[...]a recent meta-analysis has evaluated the specificity of elevated c-ANCA levels in the serum at 96.3% (CI [94.1-98.5]),4 which, combined with the high pretest probability of vasculitis (mononeuritis multiplex, acute renal failure, inflammatory anemia, multifocal brain infarcts), made a diagnosis of ANCA vasculitis highly probable even without a gold-standard pathological diagnosis. Figure 1 Axial view of a head CT showing massive bitemporal haemorrhages with significant mass effect.</description><identifier>ISSN: 0317-1671</identifier><identifier>EISSN: 2057-0155</identifier><identifier>DOI: 10.1017/cjn.2016.401</identifier><identifier>PMID: 27805540</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Aged ; Anemia ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - diagnosis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - diagnostic imaging ; Biopsy ; Cerebral Hemorrhage - diagnostic imaging ; Cerebral Hemorrhage - etiology ; Creatinine ; Hematuria ; Humans ; Laboratories ; Male ; Nervous system ; Neuroimaging Highlights</subject><ispartof>Canadian journal of neurological sciences, 2017-03, Vol.44 (2), p.194-195</ispartof><rights>Copyright © The Canadian Journal of Neurological Sciences Inc. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c353t-af62670e9940e1cd4825f089e533d9d05a7d53414692eee3f1059cc882a29eb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0317167116004017/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27805540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bergeron, David</creatorcontrib><creatorcontrib>Dionne, Annie</creatorcontrib><creatorcontrib>Marchand, Raphaël</creatorcontrib><creatorcontrib>Laforce, Robert</creatorcontrib><title>Massive Bitemporal Hemorrhages in Antineutrophil Cytoplasmic Autoantibodies Vasculitis</title><title>Canadian journal of neurological sciences</title><addtitle>Can. J. Neurol. Sci</addtitle><description>ANCA-associated small vessel vasculitides are systemic diseases characterized by inflammation and necrosis of small-sized blood vessels.1 They are characterized by the presence of antineutrophil cytoplasmic antibodies (ANCAs), which primarily target the kidney, lung, skin and peripheral nervous system.2 In rare cases, they can affect the central nervous system (CNS) and cause cerebrovascular events.3 We present a patient with ANCA vasculitis who developed fatal massive bitemporal hemorrhages during the course of immunosuppressive therapy. [...]a recent meta-analysis has evaluated the specificity of elevated c-ANCA levels in the serum at 96.3% (CI [94.1-98.5]),4 which, combined with the high pretest probability of vasculitis (mononeuritis multiplex, acute renal failure, inflammatory anemia, multifocal brain infarcts), made a diagnosis of ANCA vasculitis highly probable even without a gold-standard pathological diagnosis. 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[...]a recent meta-analysis has evaluated the specificity of elevated c-ANCA levels in the serum at 96.3% (CI [94.1-98.5]),4 which, combined with the high pretest probability of vasculitis (mononeuritis multiplex, acute renal failure, inflammatory anemia, multifocal brain infarcts), made a diagnosis of ANCA vasculitis highly probable even without a gold-standard pathological diagnosis. Figure 1 Axial view of a head CT showing massive bitemporal haemorrhages with significant mass effect.</abstract><cop>New York, USA</cop><pub>Cambridge University Press</pub><pmid>27805540</pmid><doi>10.1017/cjn.2016.401</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged Anemia Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - diagnosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - diagnostic imaging Biopsy Cerebral Hemorrhage - diagnostic imaging Cerebral Hemorrhage - etiology Creatinine Hematuria Humans Laboratories Male Nervous system Neuroimaging Highlights |
title | Massive Bitemporal Hemorrhages in Antineutrophil Cytoplasmic Autoantibodies Vasculitis |
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