Niacin and its metabolites as master regulators of macrophage activation

Niacin is a broad-spectrum lipid-regulating drug used for clinical therapy of chronic high-grade inflammatory diseases. However, the mechanisms by which either niacin or the byproducts of its catabolism ameliorate these inflammatory diseases are not clear yet. Human circulating monocytes and mature...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2017-01, Vol.39, p.40-47
Hauptverfasser:	Montserrat-de la Paz, Sergio, Naranjo, M. Carmen, Lopez, Sergio, Abia, Rocio, Muriana, Francisco J. Garcia, Bermudez, Beatriz
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Cell Differentiation - drug effects Cell Survival - drug effects Humans Macrophage Activation - drug effects Macrophages Monocytes Monocytes - drug effects Niacin Niacin - pharmacology Niacinamide - pharmacology Nicotinamide Nicotinic Acids - pharmacology Nicotinuric acid Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Oxidative Stress Polarization Pyridones - pharmacology Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction
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