Divergent and Stereoselective Synthesis of β-Silyl-α-Amino Acids through Palladium-Catalyzed Intermolecular Silylation of Unactivated Primary and Secondary C−H Bonds

A general and practical PdII‐catalyzed intermolecular silylation of primary and secondary C−H bonds of α‐amino acids and simple aliphatic acids is reported. This method provides divergent and stereoselective access to a variety of optical pure β‐silyl‐α‐amino acids, which are useful for genetic tech...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Angewandte Chemie International Edition 2016-10, Vol.55 (44), p.13859-13862
Hauptverfasser:	Liu, Yue-Jin, Liu, Yan-Hua, Zhang, Zhuo-Zhuo, Yan, Sheng-Yi, Chen, Kai, Shi, Bing-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acids asymmetric transformations chiral auxiliaries C−H activation silylation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!