Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn
[Display omitted] Seven new neolignans (1–2, 7–11) and five known compounds (3–6, 12) were isolated from the 70% EtOH extract of hawthorn seeds. Their structures were determined by spectroscopic analyses. The antioxidant and anti-inflammatory activities of all the isolates were investigated. Most of...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2016-11, Vol.26 (22), p.5501-5506 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Peng, Ying Lou, Li-Li Liu, Si-Fan Zhou, Le Huang, Xiao-Xiao Song, Shao-Jiang |
| description | [Display omitted]
Seven new neolignans (1–2, 7–11) and five known compounds (3–6, 12) were isolated from the 70% EtOH extract of hawthorn seeds. Their structures were determined by spectroscopic analyses. The antioxidant and anti-inflammatory activities of all the isolates were investigated. Most of the isolates showed moderate radical scavenging activity in the DPPH assay and significant activities in the ABTS and FRAP assays. Furthermore, compounds 7–12 exhibited marked nitric oxide (NO) inhibition and compounds 1–4 had a potent necrosis factor-α (TNF-α) inhibitory effect. The results we obtained showed that hawthorn seeds can be regarded as a potential new and cheap source of antioxidants and inflammation inhibitors. |
| doi_str_mv | 10.1016/j.bmcl.2016.10.012 |
| format | Article |
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Seven new neolignans (1–2, 7–11) and five known compounds (3–6, 12) were isolated from the 70% EtOH extract of hawthorn seeds. Their structures were determined by spectroscopic analyses. The antioxidant and anti-inflammatory activities of all the isolates were investigated. Most of the isolates showed moderate radical scavenging activity in the DPPH assay and significant activities in the ABTS and FRAP assays. Furthermore, compounds 7–12 exhibited marked nitric oxide (NO) inhibition and compounds 1–4 had a potent necrosis factor-α (TNF-α) inhibitory effect. The results we obtained showed that hawthorn seeds can be regarded as a potential new and cheap source of antioxidants and inflammation inhibitors.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2016.10.012</identifier><identifier>PMID: 27765508</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Anti-inflammatory ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Antioxidant ; Antioxidants - chemistry ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Benzothiazoles - chemistry ; Biphenyl Compounds - chemistry ; Crataegus - chemistry ; Crataegus pinnatifida ; Hawthorn ; Lignans - chemistry ; Lignans - isolation & purification ; Lignans - pharmacology ; Mice ; Neolignan ; Nitric Oxide - antagonists & inhibitors ; Picrates - chemistry ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; RAW 264.7 Cells ; Seeds ; Seeds - chemistry ; Sulfonic Acids - chemistry ; Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><ispartof>Bioorganic & medicinal chemistry letters, 2016-11, Vol.26 (22), p.5501-5506</ispartof><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-9f0fc50fce0fdb3a9a351c6e8f754d1909cac6ad23b6980f19985145cdb394c03</citedby><cites>FETCH-LOGICAL-c426t-9f0fc50fce0fdb3a9a351c6e8f754d1909cac6ad23b6980f19985145cdb394c03</cites><orcidid>0000-0002-9074-2467</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X1631040X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27765508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Ying</creatorcontrib><creatorcontrib>Lou, Li-Li</creatorcontrib><creatorcontrib>Liu, Si-Fan</creatorcontrib><creatorcontrib>Zhou, Le</creatorcontrib><creatorcontrib>Huang, Xiao-Xiao</creatorcontrib><creatorcontrib>Song, Shao-Jiang</creatorcontrib><title>Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>[Display omitted]
Seven new neolignans (1–2, 7–11) and five known compounds (3–6, 12) were isolated from the 70% EtOH extract of hawthorn seeds. Their structures were determined by spectroscopic analyses. The antioxidant and anti-inflammatory activities of all the isolates were investigated. Most of the isolates showed moderate radical scavenging activity in the DPPH assay and significant activities in the ABTS and FRAP assays. Furthermore, compounds 7–12 exhibited marked nitric oxide (NO) inhibition and compounds 1–4 had a potent necrosis factor-α (TNF-α) inhibitory effect. The results we obtained showed that hawthorn seeds can be regarded as a potential new and cheap source of antioxidants and inflammation inhibitors.</description><subject>Animals</subject><subject>Anti-inflammatory</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antioxidant</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Benzothiazoles - chemistry</subject><subject>Biphenyl Compounds - chemistry</subject><subject>Crataegus - chemistry</subject><subject>Crataegus pinnatifida</subject><subject>Hawthorn</subject><subject>Lignans - chemistry</subject><subject>Lignans - isolation & purification</subject><subject>Lignans - pharmacology</subject><subject>Mice</subject><subject>Neolignan</subject><subject>Nitric Oxide - antagonists & inhibitors</subject><subject>Picrates - chemistry</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>RAW 264.7 Cells</subject><subject>Seeds</subject><subject>Seeds - chemistry</subject><subject>Sulfonic Acids - chemistry</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlb_gAfZo5ddk90kuwEvRbQKBS8K3kKaD5uym9QkVfvvTWn16GGYYXjmJXkAuESwQhDRm1W1GGRf1XnOiwqi-giMEaa4bDAkx2AMGYVlx_DbCJzFuIIQYYjxKRjVbUsJgd0YzKYuWf9tlXCpEE7lSra0zvRiGETyYVs47Xv77oSLhQl-KNJSF1FrFQtviqX4Sksf3Dk4MaKP-uLQJ-D14f7l7rGcP8-e7qbzUuKappIZaCTJpaFRi0Yw0RAkqe5MS7BCDDIpJBWqbhaUddAgxjqCMJEZZljCZgKu97nr4D82OiY-2Ch134v8zE3kqGsIQZS2OKP1HpXBxxi04etgBxG2HEG-E8hXfCeQ7wTudllgPro65G8Wg1Z_J7_GMnC7B3T-5afVgUdptZNa2aBl4srb__J_AEHdgiY</recordid><startdate>20161115</startdate><enddate>20161115</enddate><creator>Peng, Ying</creator><creator>Lou, Li-Li</creator><creator>Liu, Si-Fan</creator><creator>Zhou, Le</creator><creator>Huang, Xiao-Xiao</creator><creator>Song, Shao-Jiang</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9074-2467</orcidid></search><sort><creationdate>20161115</creationdate><title>Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn</title><author>Peng, Ying ; Lou, Li-Li ; Liu, Si-Fan ; Zhou, Le ; Huang, Xiao-Xiao ; Song, Shao-Jiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-9f0fc50fce0fdb3a9a351c6e8f754d1909cac6ad23b6980f19985145cdb394c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Anti-inflammatory</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antioxidant</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Benzothiazoles - chemistry</topic><topic>Biphenyl Compounds - chemistry</topic><topic>Crataegus - chemistry</topic><topic>Crataegus pinnatifida</topic><topic>Hawthorn</topic><topic>Lignans - chemistry</topic><topic>Lignans - isolation & purification</topic><topic>Lignans - pharmacology</topic><topic>Mice</topic><topic>Neolignan</topic><topic>Nitric Oxide - antagonists & inhibitors</topic><topic>Picrates - chemistry</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>RAW 264.7 Cells</topic><topic>Seeds</topic><topic>Seeds - chemistry</topic><topic>Sulfonic Acids - chemistry</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Ying</creatorcontrib><creatorcontrib>Lou, Li-Li</creatorcontrib><creatorcontrib>Liu, Si-Fan</creatorcontrib><creatorcontrib>Zhou, Le</creatorcontrib><creatorcontrib>Huang, Xiao-Xiao</creatorcontrib><creatorcontrib>Song, Shao-Jiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Ying</au><au>Lou, Li-Li</au><au>Liu, Si-Fan</au><au>Zhou, Le</au><au>Huang, Xiao-Xiao</au><au>Song, Shao-Jiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2016-11-15</date><risdate>2016</risdate><volume>26</volume><issue>22</issue><spage>5501</spage><epage>5506</epage><pages>5501-5506</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>[Display omitted]
Seven new neolignans (1–2, 7–11) and five known compounds (3–6, 12) were isolated from the 70% EtOH extract of hawthorn seeds. Their structures were determined by spectroscopic analyses. The antioxidant and anti-inflammatory activities of all the isolates were investigated. Most of the isolates showed moderate radical scavenging activity in the DPPH assay and significant activities in the ABTS and FRAP assays. Furthermore, compounds 7–12 exhibited marked nitric oxide (NO) inhibition and compounds 1–4 had a potent necrosis factor-α (TNF-α) inhibitory effect. The results we obtained showed that hawthorn seeds can be regarded as a potential new and cheap source of antioxidants and inflammation inhibitors.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27765508</pmid><doi>10.1016/j.bmcl.2016.10.012</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9074-2467</orcidid></addata></record> |
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| subjects | Animals Anti-inflammatory Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Antioxidant Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Benzothiazoles - chemistry Biphenyl Compounds - chemistry Crataegus - chemistry Crataegus pinnatifida Hawthorn Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Mice Neolignan Nitric Oxide - antagonists & inhibitors Picrates - chemistry Plant Extracts - chemistry Plant Extracts - pharmacology RAW 264.7 Cells Seeds Seeds - chemistry Sulfonic Acids - chemistry Tumor Necrosis Factor-alpha - antagonists & inhibitors |
| title | Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn |
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