Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring

Reduced mitochondrial function is an important cause of aging and age-related diseases. We previously revealed a relatively higher level of mitochondrial DNA (mtDNA) content in centenarians. However, it is still unknown whether such an mtDNA content pattern of centenarians could be passed on to thei...

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Veröffentlicht in:	Neurobiology of aging 2016-11, Vol.47, p.218.e11-218.e18
Hauptverfasser:	He, Yong-Han, Chen, Xiao-Qiong, Yan, Dong-Jing, Xiao, Fu-Hui, Lin, Rong, Liao, Xiao-Ping, Liu, Yao-Wen, Pu, Shao-Yan, Yu, Qin, Sun, Hong-Peng, Jiang, Jian-Jun, Cai, Wang-Wei, Kong, Qing-Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged, 80 and over Copy number DNA Copy Number Variations - genetics DNA, Mitochondrial - genetics DNA-Binding Proteins - genetics Energy Metabolism - genetics Familial longevity Female Genetic Association Studies Humans Longevity - genetics Male Mitochondrial DNA Single-stranded DNA-binding protein 4
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