Spectrally selective three‐dimensional dynamic balanced steady‐state free precession for hyperpolarized C‐13 metabolic imaging with spectrally selective radiofrequency pulses
Purpose Balanced steady‐state free precession (bSSFP) sequences can provide superior signal‐to‐noise ratio efficiency for hyperpolarized (HP) carbon‐13 (13C) magnetic resonance imaging by efficiently utilizing the nonrecoverable magnetization, but managing their spectral response is challenging in t...
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| Veröffentlicht in: | Magnetic resonance in medicine 2017-09, Vol.78 (3), p.963-975 |
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| creator | Shang, Hong Sukumar, Subramaniam Morze, Cornelius Bok, Robert A. Marco‐Rius, Irene Kerr, Adam Reed, Galen D. Milshteyn, Eugene Ohliger, Michael A. Kurhanewicz, John Larson, Peder E.Z. Pauly, John M. Vigneron, Daniel B. |
| description | Purpose
Balanced steady‐state free precession (bSSFP) sequences can provide superior signal‐to‐noise ratio efficiency for hyperpolarized (HP) carbon‐13 (13C) magnetic resonance imaging by efficiently utilizing the nonrecoverable magnetization, but managing their spectral response is challenging in the context of metabolic imaging. A new spectrally selective bSSFP sequence was developed for fast imaging of multiple HP 13C metabolites with high spatiotemporal resolution.
Theory and Methods
This novel approach for bSSFP spectral selectivity incorporates optimized short‐duration spectrally selective radiofrequency pulses within a bSSFP pulse train and a carefully chosen repetition time to avoid banding artifacts.
Results
The sequence enabled subsecond 3D dynamic spectrally selective imaging of 13C metabolites of copolarized [1‐13C]pyruvate and [13C]urea at 2‐mm isotropic resolution, with excellent spectral selectivity (∼100:1). The sequence was successfully tested in phantom studies and in vivo studies with normal mice.
Conclusion
This sequence is expected to benefit applications requiring dynamic volumetric imaging of metabolically active 13C compounds at high spatiotemporal resolution, including preclinical studies at high field and, potentially, clinical studies. Magn Reson Med 78:963–975, 2017. © 2016 International Society for Magnetic Resonance in Medicine. |
| doi_str_mv | 10.1002/mrm.26480 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1835513905</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1835513905</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3880-8b724c48a299eb220c3b91075de8573c8883f6470a644f565755190c075a47743</originalsourceid><addsrcrecordid>eNp1kUtuFDEQhi0EIkNgwQWQJTaw6MTPtr1EI15SIiQe65bbXZ1x5H5g9yRqVhyBw3AiTkKFCSwQrKoW3_-pVD8hjzk74YyJ0yEPJ6JWlt0hG66FqIR26i7ZMKNYJblTR-RBKZeMMeeMuk-OhDGGKW035PuHGcKSfUorLZBwj1dAl10G-PH1WxcHGEucRp9ot45-iIG2PvkxQEfLAr5bkSqLX4D2GKFzhgDlJkH7KdPdOkOep-Rz_IKJLcJc0gEW304JXXHwF3G8oNdx2dHyr0uy7-KE6s97GMNK530qUB6Se73H5dHtPCafXr38uH1Tnb17_Xb74qwK0lpW2dYIFZT1wjlohWBBto4zozuw2shgrZV9rQzztVK9rrXRmjsWkPDKGCWPybODd84THlCWZoglQMIHwLQvDbcSE9IxjejTv9DLaZ_xb0g54ZSuJa-Ren6gQp5KydA3c8Yf5LXhrLmpssEqm19VIvvk1rhvB-j-kL-7Q-D0AFzHBOv_Tc35-_OD8ifEgK55</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1929456316</pqid></control><display><type>article</type><title>Spectrally selective three‐dimensional dynamic balanced steady‐state free precession for hyperpolarized C‐13 metabolic imaging with spectrally selective radiofrequency pulses</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Free Content</source><creator>Shang, Hong ; Sukumar, Subramaniam ; Morze, Cornelius ; Bok, Robert A. ; Marco‐Rius, Irene ; Kerr, Adam ; Reed, Galen D. ; Milshteyn, Eugene ; Ohliger, Michael A. ; Kurhanewicz, John ; Larson, Peder E.Z. ; Pauly, John M. ; Vigneron, Daniel B.</creator><creatorcontrib>Shang, Hong ; Sukumar, Subramaniam ; Morze, Cornelius ; Bok, Robert A. ; Marco‐Rius, Irene ; Kerr, Adam ; Reed, Galen D. ; Milshteyn, Eugene ; Ohliger, Michael A. ; Kurhanewicz, John ; Larson, Peder E.Z. ; Pauly, John M. ; Vigneron, Daniel B.</creatorcontrib><description>Purpose
Balanced steady‐state free precession (bSSFP) sequences can provide superior signal‐to‐noise ratio efficiency for hyperpolarized (HP) carbon‐13 (13C) magnetic resonance imaging by efficiently utilizing the nonrecoverable magnetization, but managing their spectral response is challenging in the context of metabolic imaging. A new spectrally selective bSSFP sequence was developed for fast imaging of multiple HP 13C metabolites with high spatiotemporal resolution.
Theory and Methods
This novel approach for bSSFP spectral selectivity incorporates optimized short‐duration spectrally selective radiofrequency pulses within a bSSFP pulse train and a carefully chosen repetition time to avoid banding artifacts.
Results
The sequence enabled subsecond 3D dynamic spectrally selective imaging of 13C metabolites of copolarized [1‐13C]pyruvate and [13C]urea at 2‐mm isotropic resolution, with excellent spectral selectivity (∼100:1). The sequence was successfully tested in phantom studies and in vivo studies with normal mice.
Conclusion
This sequence is expected to benefit applications requiring dynamic volumetric imaging of metabolically active 13C compounds at high spatiotemporal resolution, including preclinical studies at high field and, potentially, clinical studies. Magn Reson Med 78:963–975, 2017. © 2016 International Society for Magnetic Resonance in Medicine.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.26480</identifier><identifier>PMID: 27770458</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; balanced SSFP ; Banding ; banding artifact ; Carbon Isotopes - analysis ; Carbon Isotopes - chemistry ; Carbon Isotopes - metabolism ; Computer Simulation ; hyperpolarized C‐13 ; Imaging, Three-Dimensional - methods ; In vivo methods and tests ; Lactates - analysis ; Lactates - chemistry ; Lactates - metabolism ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Metabolism ; Metabolites ; Mice ; optimized RF pulse design ; Phantoms, Imaging ; Precession ; Pyruvic acid ; Pyruvic Acid - analysis ; Pyruvic Acid - chemistry ; Pyruvic Acid - metabolism ; Radio frequency ; Resonance ; Selectivity ; Spectral sensitivity ; spectrally selective ; Urea</subject><ispartof>Magnetic resonance in medicine, 2017-09, Vol.78 (3), p.963-975</ispartof><rights>2016 International Society for Magnetic Resonance in Medicine.</rights><rights>2017 International Society for Magnetic Resonance in Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3880-8b724c48a299eb220c3b91075de8573c8883f6470a644f565755190c075a47743</citedby><cites>FETCH-LOGICAL-c3880-8b724c48a299eb220c3b91075de8573c8883f6470a644f565755190c075a47743</cites><orcidid>0000-0003-4183-3634</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.26480$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.26480$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27770458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shang, Hong</creatorcontrib><creatorcontrib>Sukumar, Subramaniam</creatorcontrib><creatorcontrib>Morze, Cornelius</creatorcontrib><creatorcontrib>Bok, Robert A.</creatorcontrib><creatorcontrib>Marco‐Rius, Irene</creatorcontrib><creatorcontrib>Kerr, Adam</creatorcontrib><creatorcontrib>Reed, Galen D.</creatorcontrib><creatorcontrib>Milshteyn, Eugene</creatorcontrib><creatorcontrib>Ohliger, Michael A.</creatorcontrib><creatorcontrib>Kurhanewicz, John</creatorcontrib><creatorcontrib>Larson, Peder E.Z.</creatorcontrib><creatorcontrib>Pauly, John M.</creatorcontrib><creatorcontrib>Vigneron, Daniel B.</creatorcontrib><title>Spectrally selective three‐dimensional dynamic balanced steady‐state free precession for hyperpolarized C‐13 metabolic imaging with spectrally selective radiofrequency pulses</title><title>Magnetic resonance in medicine</title><addtitle>Magn Reson Med</addtitle><description>Purpose
Balanced steady‐state free precession (bSSFP) sequences can provide superior signal‐to‐noise ratio efficiency for hyperpolarized (HP) carbon‐13 (13C) magnetic resonance imaging by efficiently utilizing the nonrecoverable magnetization, but managing their spectral response is challenging in the context of metabolic imaging. A new spectrally selective bSSFP sequence was developed for fast imaging of multiple HP 13C metabolites with high spatiotemporal resolution.
Theory and Methods
This novel approach for bSSFP spectral selectivity incorporates optimized short‐duration spectrally selective radiofrequency pulses within a bSSFP pulse train and a carefully chosen repetition time to avoid banding artifacts.
Results
The sequence enabled subsecond 3D dynamic spectrally selective imaging of 13C metabolites of copolarized [1‐13C]pyruvate and [13C]urea at 2‐mm isotropic resolution, with excellent spectral selectivity (∼100:1). The sequence was successfully tested in phantom studies and in vivo studies with normal mice.
Conclusion
This sequence is expected to benefit applications requiring dynamic volumetric imaging of metabolically active 13C compounds at high spatiotemporal resolution, including preclinical studies at high field and, potentially, clinical studies. Magn Reson Med 78:963–975, 2017. © 2016 International Society for Magnetic Resonance in Medicine.</description><subject>Animals</subject><subject>balanced SSFP</subject><subject>Banding</subject><subject>banding artifact</subject><subject>Carbon Isotopes - analysis</subject><subject>Carbon Isotopes - chemistry</subject><subject>Carbon Isotopes - metabolism</subject><subject>Computer Simulation</subject><subject>hyperpolarized C‐13</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>In vivo methods and tests</subject><subject>Lactates - analysis</subject><subject>Lactates - chemistry</subject><subject>Lactates - metabolism</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Mice</subject><subject>optimized RF pulse design</subject><subject>Phantoms, Imaging</subject><subject>Precession</subject><subject>Pyruvic acid</subject><subject>Pyruvic Acid - analysis</subject><subject>Pyruvic Acid - chemistry</subject><subject>Pyruvic Acid - metabolism</subject><subject>Radio frequency</subject><subject>Resonance</subject><subject>Selectivity</subject><subject>Spectral sensitivity</subject><subject>spectrally selective</subject><subject>Urea</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtuFDEQhi0EIkNgwQWQJTaw6MTPtr1EI15SIiQe65bbXZ1x5H5g9yRqVhyBw3AiTkKFCSwQrKoW3_-pVD8hjzk74YyJ0yEPJ6JWlt0hG66FqIR26i7ZMKNYJblTR-RBKZeMMeeMuk-OhDGGKW035PuHGcKSfUorLZBwj1dAl10G-PH1WxcHGEucRp9ot45-iIG2PvkxQEfLAr5bkSqLX4D2GKFzhgDlJkH7KdPdOkOep-Rz_IKJLcJc0gEW304JXXHwF3G8oNdx2dHyr0uy7-KE6s97GMNK530qUB6Se73H5dHtPCafXr38uH1Tnb17_Xb74qwK0lpW2dYIFZT1wjlohWBBto4zozuw2shgrZV9rQzztVK9rrXRmjsWkPDKGCWPybODd84THlCWZoglQMIHwLQvDbcSE9IxjejTv9DLaZ_xb0g54ZSuJa-Ren6gQp5KydA3c8Yf5LXhrLmpssEqm19VIvvk1rhvB-j-kL-7Q-D0AFzHBOv_Tc35-_OD8ifEgK55</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Shang, Hong</creator><creator>Sukumar, Subramaniam</creator><creator>Morze, Cornelius</creator><creator>Bok, Robert A.</creator><creator>Marco‐Rius, Irene</creator><creator>Kerr, Adam</creator><creator>Reed, Galen D.</creator><creator>Milshteyn, Eugene</creator><creator>Ohliger, Michael A.</creator><creator>Kurhanewicz, John</creator><creator>Larson, Peder E.Z.</creator><creator>Pauly, John M.</creator><creator>Vigneron, Daniel B.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4183-3634</orcidid></search><sort><creationdate>201709</creationdate><title>Spectrally selective three‐dimensional dynamic balanced steady‐state free precession for hyperpolarized C‐13 metabolic imaging with spectrally selective radiofrequency pulses</title><author>Shang, Hong ; Sukumar, Subramaniam ; Morze, Cornelius ; Bok, Robert A. ; Marco‐Rius, Irene ; Kerr, Adam ; Reed, Galen D. ; Milshteyn, Eugene ; Ohliger, Michael A. ; Kurhanewicz, John ; Larson, Peder E.Z. ; Pauly, John M. ; Vigneron, Daniel B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3880-8b724c48a299eb220c3b91075de8573c8883f6470a644f565755190c075a47743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>balanced SSFP</topic><topic>Banding</topic><topic>banding artifact</topic><topic>Carbon Isotopes - analysis</topic><topic>Carbon Isotopes - chemistry</topic><topic>Carbon Isotopes - metabolism</topic><topic>Computer Simulation</topic><topic>hyperpolarized C‐13</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>In vivo methods and tests</topic><topic>Lactates - analysis</topic><topic>Lactates - chemistry</topic><topic>Lactates - metabolism</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Mice</topic><topic>optimized RF pulse design</topic><topic>Phantoms, Imaging</topic><topic>Precession</topic><topic>Pyruvic acid</topic><topic>Pyruvic Acid - analysis</topic><topic>Pyruvic Acid - chemistry</topic><topic>Pyruvic Acid - metabolism</topic><topic>Radio frequency</topic><topic>Resonance</topic><topic>Selectivity</topic><topic>Spectral sensitivity</topic><topic>spectrally selective</topic><topic>Urea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shang, Hong</creatorcontrib><creatorcontrib>Sukumar, Subramaniam</creatorcontrib><creatorcontrib>Morze, Cornelius</creatorcontrib><creatorcontrib>Bok, Robert A.</creatorcontrib><creatorcontrib>Marco‐Rius, Irene</creatorcontrib><creatorcontrib>Kerr, Adam</creatorcontrib><creatorcontrib>Reed, Galen D.</creatorcontrib><creatorcontrib>Milshteyn, Eugene</creatorcontrib><creatorcontrib>Ohliger, Michael A.</creatorcontrib><creatorcontrib>Kurhanewicz, John</creatorcontrib><creatorcontrib>Larson, Peder E.Z.</creatorcontrib><creatorcontrib>Pauly, John M.</creatorcontrib><creatorcontrib>Vigneron, Daniel B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shang, Hong</au><au>Sukumar, Subramaniam</au><au>Morze, Cornelius</au><au>Bok, Robert A.</au><au>Marco‐Rius, Irene</au><au>Kerr, Adam</au><au>Reed, Galen D.</au><au>Milshteyn, Eugene</au><au>Ohliger, Michael A.</au><au>Kurhanewicz, John</au><au>Larson, Peder E.Z.</au><au>Pauly, John M.</au><au>Vigneron, Daniel B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spectrally selective three‐dimensional dynamic balanced steady‐state free precession for hyperpolarized C‐13 metabolic imaging with spectrally selective radiofrequency pulses</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn Reson Med</addtitle><date>2017-09</date><risdate>2017</risdate><volume>78</volume><issue>3</issue><spage>963</spage><epage>975</epage><pages>963-975</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>Purpose
Balanced steady‐state free precession (bSSFP) sequences can provide superior signal‐to‐noise ratio efficiency for hyperpolarized (HP) carbon‐13 (13C) magnetic resonance imaging by efficiently utilizing the nonrecoverable magnetization, but managing their spectral response is challenging in the context of metabolic imaging. A new spectrally selective bSSFP sequence was developed for fast imaging of multiple HP 13C metabolites with high spatiotemporal resolution.
Theory and Methods
This novel approach for bSSFP spectral selectivity incorporates optimized short‐duration spectrally selective radiofrequency pulses within a bSSFP pulse train and a carefully chosen repetition time to avoid banding artifacts.
Results
The sequence enabled subsecond 3D dynamic spectrally selective imaging of 13C metabolites of copolarized [1‐13C]pyruvate and [13C]urea at 2‐mm isotropic resolution, with excellent spectral selectivity (∼100:1). The sequence was successfully tested in phantom studies and in vivo studies with normal mice.
Conclusion
This sequence is expected to benefit applications requiring dynamic volumetric imaging of metabolically active 13C compounds at high spatiotemporal resolution, including preclinical studies at high field and, potentially, clinical studies. Magn Reson Med 78:963–975, 2017. © 2016 International Society for Magnetic Resonance in Medicine.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27770458</pmid><doi>10.1002/mrm.26480</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-4183-3634</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Magnetic resonance in medicine, 2017-09, Vol.78 (3), p.963-975 |
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| subjects | Animals balanced SSFP Banding banding artifact Carbon Isotopes - analysis Carbon Isotopes - chemistry Carbon Isotopes - metabolism Computer Simulation hyperpolarized C‐13 Imaging, Three-Dimensional - methods In vivo methods and tests Lactates - analysis Lactates - chemistry Lactates - metabolism Magnetic resonance imaging Magnetic Resonance Imaging - methods Metabolism Metabolites Mice optimized RF pulse design Phantoms, Imaging Precession Pyruvic acid Pyruvic Acid - analysis Pyruvic Acid - chemistry Pyruvic Acid - metabolism Radio frequency Resonance Selectivity Spectral sensitivity spectrally selective Urea |
| title | Spectrally selective three‐dimensional dynamic balanced steady‐state free precession for hyperpolarized C‐13 metabolic imaging with spectrally selective radiofrequency pulses |
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