The nuclear cofactor Receptor interacting protein-140 (RIP140) regulates the expression of genes involved in Aβ generation

Abstract The Receptor Interacting Protein 140 (RIP140) is a cofactor for several nuclear receptors and has been involved in the regulation of metabolic and inflammatory genes. We hypothesize that RIP140 may also affect Aβ generation because it modulates the activity of transcription factors previous...

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Veröffentlicht in:	Neurobiology of aging 2016-11, Vol.47, p.180-191
Hauptverfasser:	Blondrath, Katrin, Steel, Jennifer H, Katsouri, Loukia, Ries, Miriam, Parker, Malcolm G, Christian, Mark, Sastre, Magdalena
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Adaptor Proteins, Signal Transducing - physiology Alzheimer Disease - genetics Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases Animals Aspartic Acid Endopeptidases BACE1 Brain - metabolism Cells, Cultured Female Gene Expression - genetics Gene Expression Regulation, Developmental - genetics Glycogen Synthase Kinase 3 GSK3 Humans Internal Medicine Male Mice Mice, Knockout Mice, Transgenic Neurology Nuclear Proteins - metabolism Nuclear Proteins - physiology PPAR gamma - metabolism PPARγ RIP140 Signal Transduction Transcription, Genetic - genetics
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