Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion
In a pragmatic trial, more than 30,000 patients requiring blood transfusion were randomly assigned to receive blood after short-term storage or long-term storage. In-hospital mortality did not differ significantly between the two groups. Red-cell transfusion is one of the most common medical interve...
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| Veröffentlicht in: | The New England journal of medicine 2016-11, Vol.375 (20), p.1937-1945 |
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| container_title | The New England journal of medicine |
| container_volume | 375 |
| creator | Heddle, Nancy M Cook, Richard J Arnold, Donald M Liu, Yang Barty, Rebecca Crowther, Mark A Devereaux, P.J Hirsh, Jack Warkentin, Theodore E Webert, Kathryn E Roxby, David Sobieraj-Teague, Magdalena Kurz, Andrea Sessler, Daniel I Figueroa, Priscilla Ellis, Martin Eikelboom, John W |
| description | In a pragmatic trial, more than 30,000 patients requiring blood transfusion were randomly assigned to receive blood after short-term storage or long-term storage. In-hospital mortality did not differ significantly between the two groups.
Red-cell transfusion is one of the most common medical interventions.
1
Blood is stored for up to 42 days before transfusion. Biochemical, structural, and functional changes during storage may reduce oxygen delivery to tissues, and the release of extracellular vesicles and cell-free DNA during storage may cause a hypercoagulable state.
2
Observational studies have suggested that prolonged blood storage is associated with an increased risk of cardiovascular events.
3
Randomized, controlled trials have not shown harm in transfusing red-cell units with a longer duration versus a shorter duration of storage. However, most of these trials have been restricted to high-risk populations and have . . . |
| doi_str_mv | 10.1056/NEJMoa1609014 |
| format | Article |
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Red-cell transfusion is one of the most common medical interventions.
1
Blood is stored for up to 42 days before transfusion. Biochemical, structural, and functional changes during storage may reduce oxygen delivery to tissues, and the release of extracellular vesicles and cell-free DNA during storage may cause a hypercoagulable state.
2
Observational studies have suggested that prolonged blood storage is associated with an increased risk of cardiovascular events.
3
Randomized, controlled trials have not shown harm in transfusing red-cell units with a longer duration versus a shorter duration of storage. However, most of these trials have been restricted to high-risk populations and have . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1609014</identifier><identifier>PMID: 27775503</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adult ; Aged ; Blood ; Blood & organ donations ; Blood Preservation ; Blood transfusion ; Blood Transfusion - methods ; Blood Transfusion - mortality ; Blood transfusions ; Cancer ; Cardiovascular diseases ; Clinical trials ; Data processing ; Female ; Hospital Mortality ; Hospitalization ; Humans ; Logistic Models ; Long term ; Male ; Middle Aged ; Mortality ; Patients ; Risk groups ; Short term ; Storage ; Surgery ; Time Factors</subject><ispartof>The New England journal of medicine, 2016-11, Vol.375 (20), p.1937-1945</ispartof><rights>Copyright © 2016 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-4e5a1eb97f5d228a96f121a270ad1c59fc659d313589ff2baeb49421ff70c1243</citedby><cites>FETCH-LOGICAL-c456t-4e5a1eb97f5d228a96f121a270ad1c59fc659d313589ff2baeb49421ff70c1243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1609014$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1609014$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27775503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heddle, Nancy M</creatorcontrib><creatorcontrib>Cook, Richard J</creatorcontrib><creatorcontrib>Arnold, Donald M</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Barty, Rebecca</creatorcontrib><creatorcontrib>Crowther, Mark A</creatorcontrib><creatorcontrib>Devereaux, P.J</creatorcontrib><creatorcontrib>Hirsh, Jack</creatorcontrib><creatorcontrib>Warkentin, Theodore E</creatorcontrib><creatorcontrib>Webert, Kathryn E</creatorcontrib><creatorcontrib>Roxby, David</creatorcontrib><creatorcontrib>Sobieraj-Teague, Magdalena</creatorcontrib><creatorcontrib>Kurz, Andrea</creatorcontrib><creatorcontrib>Sessler, Daniel I</creatorcontrib><creatorcontrib>Figueroa, Priscilla</creatorcontrib><creatorcontrib>Ellis, Martin</creatorcontrib><creatorcontrib>Eikelboom, John W</creatorcontrib><title>Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In a pragmatic trial, more than 30,000 patients requiring blood transfusion were randomly assigned to receive blood after short-term storage or long-term storage. In-hospital mortality did not differ significantly between the two groups.
Red-cell transfusion is one of the most common medical interventions.
1
Blood is stored for up to 42 days before transfusion. Biochemical, structural, and functional changes during storage may reduce oxygen delivery to tissues, and the release of extracellular vesicles and cell-free DNA during storage may cause a hypercoagulable state.
2
Observational studies have suggested that prolonged blood storage is associated with an increased risk of cardiovascular events.
3
Randomized, controlled trials have not shown harm in transfusing red-cell units with a longer duration versus a shorter duration of storage. However, most of these trials have been restricted to high-risk populations and have . . .</description><subject>Adult</subject><subject>Aged</subject><subject>Blood</subject><subject>Blood & organ donations</subject><subject>Blood Preservation</subject><subject>Blood transfusion</subject><subject>Blood Transfusion - methods</subject><subject>Blood Transfusion - mortality</subject><subject>Blood transfusions</subject><subject>Cancer</subject><subject>Cardiovascular diseases</subject><subject>Clinical trials</subject><subject>Data processing</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Long term</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patients</subject><subject>Risk groups</subject><subject>Short term</subject><subject>Storage</subject><subject>Surgery</subject><subject>Time Factors</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10M1LwzAYBvAgipvTo1cJiOClM59Nc9Qxv9jcYfNc0jaZHW0zk1bYf2-kU1Awl5fAj-d9eQA4x2iMEY9vXqbPc6twjCTC7AAMMac0YgzFh2CIEEkiJiQdgBPvNyg8zOQxGBAhBOeIDsFiaozOW2gNXL5Z10Yr7Wr44cdwZpt1_7urrC3gsrVOrTW0DZwHqKqy3UFlWu3gyqnGm86XtjkFR0ZVXp_t5wi83k9Xk8dotnh4mtzOopzxuI2Y5grrTArDC0ISJWODCVZEIFXgnEuTx1wWFFOeSGNIpnTGJCPYGIFyTBgdges-d-vse6d9m9alz3VVqUbbzqc4oZxjknAe6OUfurGda8J1QbGwlsUCBRX1KnfWe6dNunVlrdwuxSj9ajr91XTwF_vULqt18aO_qw3gqgd17dNGb-p_gj4BMFOCiw</recordid><startdate>20161117</startdate><enddate>20161117</enddate><creator>Heddle, Nancy M</creator><creator>Cook, Richard J</creator><creator>Arnold, Donald M</creator><creator>Liu, Yang</creator><creator>Barty, Rebecca</creator><creator>Crowther, Mark A</creator><creator>Devereaux, P.J</creator><creator>Hirsh, Jack</creator><creator>Warkentin, Theodore E</creator><creator>Webert, Kathryn E</creator><creator>Roxby, David</creator><creator>Sobieraj-Teague, Magdalena</creator><creator>Kurz, Andrea</creator><creator>Sessler, Daniel I</creator><creator>Figueroa, Priscilla</creator><creator>Ellis, Martin</creator><creator>Eikelboom, John W</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20161117</creationdate><title>Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion</title><author>Heddle, Nancy M ; Cook, Richard J ; Arnold, Donald M ; Liu, Yang ; Barty, Rebecca ; Crowther, Mark A ; Devereaux, P.J ; Hirsh, Jack ; Warkentin, Theodore E ; Webert, Kathryn E ; Roxby, David ; Sobieraj-Teague, Magdalena ; Kurz, Andrea ; Sessler, Daniel I ; Figueroa, Priscilla ; Ellis, Martin ; Eikelboom, John W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-4e5a1eb97f5d228a96f121a270ad1c59fc659d313589ff2baeb49421ff70c1243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood</topic><topic>Blood & organ donations</topic><topic>Blood Preservation</topic><topic>Blood transfusion</topic><topic>Blood Transfusion - methods</topic><topic>Blood Transfusion - mortality</topic><topic>Blood transfusions</topic><topic>Cancer</topic><topic>Cardiovascular diseases</topic><topic>Clinical trials</topic><topic>Data processing</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Long term</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Patients</topic><topic>Risk groups</topic><topic>Short term</topic><topic>Storage</topic><topic>Surgery</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heddle, Nancy M</creatorcontrib><creatorcontrib>Cook, Richard J</creatorcontrib><creatorcontrib>Arnold, Donald M</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Barty, Rebecca</creatorcontrib><creatorcontrib>Crowther, Mark A</creatorcontrib><creatorcontrib>Devereaux, P.J</creatorcontrib><creatorcontrib>Hirsh, Jack</creatorcontrib><creatorcontrib>Warkentin, Theodore E</creatorcontrib><creatorcontrib>Webert, Kathryn E</creatorcontrib><creatorcontrib>Roxby, David</creatorcontrib><creatorcontrib>Sobieraj-Teague, Magdalena</creatorcontrib><creatorcontrib>Kurz, Andrea</creatorcontrib><creatorcontrib>Sessler, Daniel I</creatorcontrib><creatorcontrib>Figueroa, Priscilla</creatorcontrib><creatorcontrib>Ellis, Martin</creatorcontrib><creatorcontrib>Eikelboom, John W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>ProQuest Health Management</collection><collection>Medical Database</collection><collection>ProQuest Psychology Journals</collection><collection>ProQuest Research Library</collection><collection>ProQuest Science Journals</collection><collection>ProQuest Biological Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heddle, Nancy M</au><au>Cook, Richard J</au><au>Arnold, Donald M</au><au>Liu, Yang</au><au>Barty, Rebecca</au><au>Crowther, Mark A</au><au>Devereaux, P.J</au><au>Hirsh, Jack</au><au>Warkentin, Theodore E</au><au>Webert, Kathryn E</au><au>Roxby, David</au><au>Sobieraj-Teague, Magdalena</au><au>Kurz, Andrea</au><au>Sessler, Daniel I</au><au>Figueroa, Priscilla</au><au>Ellis, Martin</au><au>Eikelboom, John W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2016-11-17</date><risdate>2016</risdate><volume>375</volume><issue>20</issue><spage>1937</spage><epage>1945</epage><pages>1937-1945</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>In a pragmatic trial, more than 30,000 patients requiring blood transfusion were randomly assigned to receive blood after short-term storage or long-term storage. In-hospital mortality did not differ significantly between the two groups.
Red-cell transfusion is one of the most common medical interventions.
1
Blood is stored for up to 42 days before transfusion. Biochemical, structural, and functional changes during storage may reduce oxygen delivery to tissues, and the release of extracellular vesicles and cell-free DNA during storage may cause a hypercoagulable state.
2
Observational studies have suggested that prolonged blood storage is associated with an increased risk of cardiovascular events.
3
Randomized, controlled trials have not shown harm in transfusing red-cell units with a longer duration versus a shorter duration of storage. However, most of these trials have been restricted to high-risk populations and have . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>27775503</pmid><doi>10.1056/NEJMoa1609014</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2016-11, Vol.375 (20), p.1937-1945 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine Current |
| subjects | Adult Aged Blood Blood & organ donations Blood Preservation Blood transfusion Blood Transfusion - methods Blood Transfusion - mortality Blood transfusions Cancer Cardiovascular diseases Clinical trials Data processing Female Hospital Mortality Hospitalization Humans Logistic Models Long term Male Middle Aged Mortality Patients Risk groups Short term Storage Surgery Time Factors |
| title | Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion |
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