Phytoconstituents as pharmacotherapeutics in rheumatoid arthritis: challenges and scope of nano/submicromedicine in its effective delivery
Objectives The present review explores the therapeutic application of herbals in rheumatoid arthritis (RA) therapy, and how nano/submicromedicine can be fit in the scope of its therapeutic delivery in RA has been addressed. Key findings Incorporation of bioactive such as polyphenols, thymoquinone, r...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2017-01, Vol.69 (1), p.1-14 |
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| creator | Rahman, Mahfoozur Beg, Sarwar Verma, Amita Al Abbasi, Fahad A. Anwar, Firoz Saini, Sumant Akhter, Sohail Kumar, Vikas |
| description | Objectives
The present review explores the therapeutic application of herbals in rheumatoid arthritis (RA) therapy, and how nano/submicromedicine can be fit in the scope of its therapeutic delivery in RA has been addressed.
Key findings
Incorporation of bioactive such as polyphenols, thymoquinone, resveratrol, hesperidin, curcumin, celastrol and gambogic acid in a dose‐dependent manner showed quite high efficacy for the treatment of RA. It can be attributed to their targeting ability against various inflammatory mediators including nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF‐kβ, lipoxygenase (LOXs) and arachidonic acid (AA). Despite the presence of significant merits, the use of these bioactives has several demerits such as poor bioavailability as a function of low aqueous solubility and higher first‐pass metabolism upon oral administration. The impact of nano/submicromedicine in the delivery of these bioactives against RA has gained wider attention owing to bioavailability enhancement, higher stability and better efficacy.
Conclusion
Phytoconstituents possess immense potential in RA pharmacotherapy, but the obstacles for their effective delivery can be overcome using nano/submicrocarrier‐based drug delivery technologies, which maximize the efficacy of these herbal antirheumatic drugs without any systemic adverse effects. |
| doi_str_mv | 10.1111/jphp.12661 |
| format | Article |
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The present review explores the therapeutic application of herbals in rheumatoid arthritis (RA) therapy, and how nano/submicromedicine can be fit in the scope of its therapeutic delivery in RA has been addressed.
Key findings
Incorporation of bioactive such as polyphenols, thymoquinone, resveratrol, hesperidin, curcumin, celastrol and gambogic acid in a dose‐dependent manner showed quite high efficacy for the treatment of RA. It can be attributed to their targeting ability against various inflammatory mediators including nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF‐kβ, lipoxygenase (LOXs) and arachidonic acid (AA). Despite the presence of significant merits, the use of these bioactives has several demerits such as poor bioavailability as a function of low aqueous solubility and higher first‐pass metabolism upon oral administration. The impact of nano/submicromedicine in the delivery of these bioactives against RA has gained wider attention owing to bioavailability enhancement, higher stability and better efficacy.
Conclusion
Phytoconstituents possess immense potential in RA pharmacotherapy, but the obstacles for their effective delivery can be overcome using nano/submicrocarrier‐based drug delivery technologies, which maximize the efficacy of these herbal antirheumatic drugs without any systemic adverse effects.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1111/jphp.12661</identifier><identifier>PMID: 27774648</identifier><identifier>CODEN: JPPMAB</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Antirheumatic Agents - administration & dosage ; Antirheumatic Agents - pharmacokinetics ; Antirheumatic Agents - pharmacology ; Antirheumatic Agents - therapeutic use ; Arthritis, Rheumatoid - drug therapy ; Bioavailability ; Biological Availability ; Drug Delivery Systems ; Drug therapy ; Humans ; liposomes ; Magnoliopsida - chemistry ; nan/submicro‐medicine ; nanoemulsion ; Nanoparticles ; Phytochemicals - administration & dosage ; Phytochemicals - pharmacokinetics ; Phytochemicals - pharmacology ; Phytochemicals - therapeutic use ; phytoconstituents ; Phytotherapy ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacokinetics ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Rheumatoid arthritis ; Rodents</subject><ispartof>Journal of pharmacy and pharmacology, 2017-01, Vol.69 (1), p.1-14</ispartof><rights>2016 Royal Pharmaceutical Society</rights><rights>2016 Royal Pharmaceutical Society.</rights><rights>Copyright © 2017 Royal Pharmaceutical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3931-be0595910f645878396409b82ea5012fbdf29fdb5a0add4bbf9180c2831514813</citedby><cites>FETCH-LOGICAL-c3931-be0595910f645878396409b82ea5012fbdf29fdb5a0add4bbf9180c2831514813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjphp.12661$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjphp.12661$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27774648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahman, Mahfoozur</creatorcontrib><creatorcontrib>Beg, Sarwar</creatorcontrib><creatorcontrib>Verma, Amita</creatorcontrib><creatorcontrib>Al Abbasi, Fahad A.</creatorcontrib><creatorcontrib>Anwar, Firoz</creatorcontrib><creatorcontrib>Saini, Sumant</creatorcontrib><creatorcontrib>Akhter, Sohail</creatorcontrib><creatorcontrib>Kumar, Vikas</creatorcontrib><title>Phytoconstituents as pharmacotherapeutics in rheumatoid arthritis: challenges and scope of nano/submicromedicine in its effective delivery</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>Objectives
The present review explores the therapeutic application of herbals in rheumatoid arthritis (RA) therapy, and how nano/submicromedicine can be fit in the scope of its therapeutic delivery in RA has been addressed.
Key findings
Incorporation of bioactive such as polyphenols, thymoquinone, resveratrol, hesperidin, curcumin, celastrol and gambogic acid in a dose‐dependent manner showed quite high efficacy for the treatment of RA. It can be attributed to their targeting ability against various inflammatory mediators including nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF‐kβ, lipoxygenase (LOXs) and arachidonic acid (AA). Despite the presence of significant merits, the use of these bioactives has several demerits such as poor bioavailability as a function of low aqueous solubility and higher first‐pass metabolism upon oral administration. The impact of nano/submicromedicine in the delivery of these bioactives against RA has gained wider attention owing to bioavailability enhancement, higher stability and better efficacy.
Conclusion
Phytoconstituents possess immense potential in RA pharmacotherapy, but the obstacles for their effective delivery can be overcome using nano/submicrocarrier‐based drug delivery technologies, which maximize the efficacy of these herbal antirheumatic drugs without any systemic adverse effects.</description><subject>Antirheumatic Agents - administration & dosage</subject><subject>Antirheumatic Agents - pharmacokinetics</subject><subject>Antirheumatic Agents - pharmacology</subject><subject>Antirheumatic Agents - therapeutic use</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Bioavailability</subject><subject>Biological Availability</subject><subject>Drug Delivery Systems</subject><subject>Drug therapy</subject><subject>Humans</subject><subject>liposomes</subject><subject>Magnoliopsida - chemistry</subject><subject>nan/submicro‐medicine</subject><subject>nanoemulsion</subject><subject>Nanoparticles</subject><subject>Phytochemicals - administration & dosage</subject><subject>Phytochemicals - pharmacokinetics</subject><subject>Phytochemicals - pharmacology</subject><subject>Phytochemicals - therapeutic use</subject><subject>phytoconstituents</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacokinetics</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Rheumatoid arthritis</subject><subject>Rodents</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQhy0EokvhwgMgS1xQpbT-EycOt6qiFFSJPcA5cuwx8Sqxg-2A9hX61PWyhUMP9WUu33zjmR9Cbyk5p-Vd7JZxOaesaegztGGkZlVLhXyONoQwVnHR8hP0KqUdIaRtmuYlOmFt29ZNLTfobjvuc9DBp-zyCj4nrBJeRhVnpUMeIaoF1ux0ws7jOMI6qxycwSrmMbrs0kesRzVN4H9C6fUGJx0WwMFir3y4SOswOx3DDMZp5-GgcWUKWAs6u9-ADUylxP1r9MKqKcGbh3qKflx_-n51U91--_zl6vK20rzjtBqAiE50lNimFrKVvGtq0g2SgRKEMjsYyzprBqGIMqYeBttRSTSTnApaS8pP0Yejd4nh1wop97NLGqZJeQhr6qnkQtAC84K-f4Tuwhp9-V2h6oYTWcYX6uxIlTVTimD7JbpZxX1PSX9IqD8k1P9NqMDvHpTlMGD-o_8iKQA9An_cBPsnVP3X7c32KL0HTVaeNw</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Rahman, Mahfoozur</creator><creator>Beg, Sarwar</creator><creator>Verma, Amita</creator><creator>Al Abbasi, Fahad A.</creator><creator>Anwar, Firoz</creator><creator>Saini, Sumant</creator><creator>Akhter, Sohail</creator><creator>Kumar, Vikas</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>Phytoconstituents as pharmacotherapeutics in rheumatoid arthritis: challenges and scope of nano/submicromedicine in its effective delivery</title><author>Rahman, Mahfoozur ; Beg, Sarwar ; Verma, Amita ; Al Abbasi, Fahad A. ; Anwar, Firoz ; Saini, Sumant ; Akhter, Sohail ; Kumar, Vikas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3931-be0595910f645878396409b82ea5012fbdf29fdb5a0add4bbf9180c2831514813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antirheumatic Agents - administration & dosage</topic><topic>Antirheumatic Agents - pharmacokinetics</topic><topic>Antirheumatic Agents - pharmacology</topic><topic>Antirheumatic Agents - therapeutic use</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Bioavailability</topic><topic>Biological Availability</topic><topic>Drug Delivery Systems</topic><topic>Drug therapy</topic><topic>Humans</topic><topic>liposomes</topic><topic>Magnoliopsida - chemistry</topic><topic>nan/submicro‐medicine</topic><topic>nanoemulsion</topic><topic>Nanoparticles</topic><topic>Phytochemicals - administration & dosage</topic><topic>Phytochemicals - pharmacokinetics</topic><topic>Phytochemicals - pharmacology</topic><topic>Phytochemicals - therapeutic use</topic><topic>phytoconstituents</topic><topic>Phytotherapy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacokinetics</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Rheumatoid arthritis</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rahman, Mahfoozur</creatorcontrib><creatorcontrib>Beg, Sarwar</creatorcontrib><creatorcontrib>Verma, Amita</creatorcontrib><creatorcontrib>Al Abbasi, Fahad A.</creatorcontrib><creatorcontrib>Anwar, Firoz</creatorcontrib><creatorcontrib>Saini, Sumant</creatorcontrib><creatorcontrib>Akhter, Sohail</creatorcontrib><creatorcontrib>Kumar, Vikas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahman, Mahfoozur</au><au>Beg, Sarwar</au><au>Verma, Amita</au><au>Al Abbasi, Fahad A.</au><au>Anwar, Firoz</au><au>Saini, Sumant</au><au>Akhter, Sohail</au><au>Kumar, Vikas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phytoconstituents as pharmacotherapeutics in rheumatoid arthritis: challenges and scope of nano/submicromedicine in its effective delivery</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2017-01</date><risdate>2017</risdate><volume>69</volume><issue>1</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><coden>JPPMAB</coden><abstract>Objectives
The present review explores the therapeutic application of herbals in rheumatoid arthritis (RA) therapy, and how nano/submicromedicine can be fit in the scope of its therapeutic delivery in RA has been addressed.
Key findings
Incorporation of bioactive such as polyphenols, thymoquinone, resveratrol, hesperidin, curcumin, celastrol and gambogic acid in a dose‐dependent manner showed quite high efficacy for the treatment of RA. It can be attributed to their targeting ability against various inflammatory mediators including nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF‐kβ, lipoxygenase (LOXs) and arachidonic acid (AA). Despite the presence of significant merits, the use of these bioactives has several demerits such as poor bioavailability as a function of low aqueous solubility and higher first‐pass metabolism upon oral administration. The impact of nano/submicromedicine in the delivery of these bioactives against RA has gained wider attention owing to bioavailability enhancement, higher stability and better efficacy.
Conclusion
Phytoconstituents possess immense potential in RA pharmacotherapy, but the obstacles for their effective delivery can be overcome using nano/submicrocarrier‐based drug delivery technologies, which maximize the efficacy of these herbal antirheumatic drugs without any systemic adverse effects.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27774648</pmid><doi>10.1111/jphp.12661</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Antirheumatic Agents - administration & dosage Antirheumatic Agents - pharmacokinetics Antirheumatic Agents - pharmacology Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Bioavailability Biological Availability Drug Delivery Systems Drug therapy Humans liposomes Magnoliopsida - chemistry nan/submicro‐medicine nanoemulsion Nanoparticles Phytochemicals - administration & dosage Phytochemicals - pharmacokinetics Phytochemicals - pharmacology Phytochemicals - therapeutic use phytoconstituents Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacokinetics Plant Extracts - pharmacology Plant Extracts - therapeutic use Rheumatoid arthritis Rodents |
| title | Phytoconstituents as pharmacotherapeutics in rheumatoid arthritis: challenges and scope of nano/submicromedicine in its effective delivery |
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