The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1

The cochaperone BAG3 is a central protein homeostasis factor in mechanically strained mammalian cells. It mediates the degradation of unfolded and damaged forms of the actin-crosslinker filamin through chaperone-assisted selective autophagy (CASA). In addition, BAG3 stimulates filamin transcription...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular cell research 2017-01, Vol.1864 (1), p.62-75
Hauptverfasser:	Kathage, Barbara, Gehlert, Sebastian, Ulbricht, Anna, Lüdecke, Laura, Tapia, Victor E, Orfanos, Zacharias, Wenzel, Daniela, Bloch, Wilhelm, Volkmer, Rudolf, Fleischmann, Bernd K, Fürst, Dieter O, Höhfeld, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Actin Cytoskeleton - ultrastructure Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino Acid Sequence Animals Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Autophagy - genetics Biomechanical Phenomena Cell Line Cloning, Molecular Escherichia coli - genetics Escherichia coli - metabolism Filamins - genetics Filamins - metabolism Gene Expression Gene Expression Regulation Humans Mechanistic Target of Rapamycin Complex 1 Mice Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - ultrastructure Protein Binding Protein Biosynthesis Rats Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Signal Transduction Stress, Mechanical TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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