Fzd7 (Frizzled-7) Expressed by Endothelial Cells Controls Blood Vessel Formation Through Wnt/β-Catenin Canonical Signaling

OBJECTIVE—Vessel formation requires precise orchestration of a series of morphometric and molecular events controlled by a multitude of angiogenic factors and morphogens. Wnt/frizzled signaling is required for proper vascular formation. In this study, we investigated the role of the Fzd7 (frizzled-7...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2016-12, Vol.36 (12), p.2369-2380
Hauptverfasser:	Peghaire, Claire, Bats, Marie Lise, Sewduth, Raj, Jeanningros, Sylvie, Jaspard, Beatrice, Couffinhal, Thierry, Duplàa, Cécile, Dufourcq, Pascale
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Animals, Newborn beta Catenin - metabolism Calcium-Binding Proteins Cell Proliferation Cells, Cultured Dishevelled Proteins - deficiency Dishevelled Proteins - genetics Endothelial Cells - drug effects Endothelial Cells - metabolism Frizzled Receptors Genotype Intracellular Signaling Peptides and Proteins - metabolism Jagged-1 Protein - metabolism Lithium Chloride - pharmacology Membrane Proteins - metabolism Mice, Inbred C57BL Mice, Knockout Neovascularization, Physiologic - drug effects Phenotype Receptors, G-Protein-Coupled - deficiency Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Notch - metabolism Retinal Neovascularization - genetics Retinal Neovascularization - metabolism Retinal Neovascularization - physiopathology Retinal Vessels - drug effects Retinal Vessels - metabolism RNA Interference Transfection Wnt Signaling Pathway - drug effects
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