LPA1 Mediates Antidepressant-Induced ERK1/2 Signaling and Protection from Oxidative Stress in Glial Cells

Antidepressants have been shown to affect glial cell functions and intracellular signaling through mechanisms that are still not completely understood. In the present study, we provide evidence that in glial cells the lysophosphatidic acid (LPA) receptor LPA1 mediates antidepressant-induced growth f...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2016-11, Vol.359 (2), p.340-353
Hauptverfasser:	Olianas, Maria C., Dedoni, Simona, Onali, Pierluigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amitriptyline - pharmacology Animals Antidepressive Agents - pharmacology Cell Line, Tumor Cyclic AMP Response Element-Binding Protein - metabolism ets-Domain Protein Elk-1 - metabolism Gene Knockdown Techniques Lysophospholipids - pharmacology MAP Kinase Signaling System - drug effects Mianserin - pharmacology Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Neuroglia - cytology Neuroglia - drug effects Neuroglia - metabolism Oxidative Stress - drug effects Pertussis Toxin - toxicity Phosphorylation - drug effects Rats Receptors, Fibroblast Growth Factor - genetics Receptors, Lysophosphatidic Acid - deficiency Receptors, Lysophosphatidic Acid - genetics Receptors, Lysophosphatidic Acid - metabolism Receptors, Platelet-Derived Growth Factor - genetics Transcriptional Activation - drug effects
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