Systemic inflammation and painful joint burden in osteoarthritis: A Matter of Sex?
Abstract Objective We investigated the association between serum levels of C-reactive protein (CRP) and the extent of multijoint pain among individuals with hip/knee osteoarthritis (OA) and determined whether the association differs by sex. Design Serum CRP and cartilage oligomeric matrix protein (C...
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| Veröffentlicht in: | Osteoarthritis and cartilage 2017-01, Vol.25 (1), p.53-59 |
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| creator | Perruccio, Anthony.V., PhD Chandran, Vinod, MD, PhD Power, J.Denise, MHSc Kapoor, Mohit, PhD Mahomed, Nizar N., MD, DSc Gandhi, Rajiv, MD, MSc |
| description | Abstract Objective We investigated the association between serum levels of C-reactive protein (CRP) and the extent of multijoint pain among individuals with hip/knee osteoarthritis (OA) and determined whether the association differs by sex. Design Serum CRP and cartilage oligomeric matrix protein (COMP) were determined by ELISA in 189 individuals (101 female, 88 male) scheduled for total hip/knee arthroplasty for OA. Patients indicated on a homunculus all painful joints; a summed count was derived. A series of negative binomial regression models was used to investigate the cross-sectional association between painful joint count (outcome) and serum CRP concentrations, adjusting for age, sex, BMI, comorbidity count and COMP. An interaction between sex and these biomarkers was tested. Results Mean age: 66 among women, 65 among men. Women had higher mean joint count (3.7 vs 2.5, p |
| doi_str_mv | 10.1016/j.joca.2016.08.001 |
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Design Serum CRP and cartilage oligomeric matrix protein (COMP) were determined by ELISA in 189 individuals (101 female, 88 male) scheduled for total hip/knee arthroplasty for OA. Patients indicated on a homunculus all painful joints; a summed count was derived. A series of negative binomial regression models was used to investigate the cross-sectional association between painful joint count (outcome) and serum CRP concentrations, adjusting for age, sex, BMI, comorbidity count and COMP. An interaction between sex and these biomarkers was tested. Results Mean age: 66 among women, 65 among men. Women had higher mean joint count (3.7 vs 2.5, p<0.01; 4+ joint count reported by 37% women, 25% men). Median CRP concentration was higher in women (15.4 mg/l vs 9.3, p=0.07). From adjusted analyses, the effects of both ln(CRP) and ln(COMP) were modified by sex (p<0.05). Increasing ln(CRP) was associated with greater painful joint count among women, but not men. Conclusions There may be a dose-response association between painful joint burden in OA and systemic inflammation, and it appears the association is sex-specific, which may in part explain inconsistent findings in the literature. Our results underline the importance of showing sex-specific associations in OA, especially when studying the influence of inflammation.</description><identifier>ISSN: 1063-4584</identifier><identifier>EISSN: 1522-9653</identifier><identifier>DOI: 10.1016/j.joca.2016.08.001</identifier><identifier>PMID: 27546883</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Arthralgia - pathology ; Biomarkers - blood ; Body Mass Index ; C-reactive protein ; C-Reactive Protein - analysis ; Cartilage Oligomeric Matrix Protein - blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Inflammation ; Inflammation - pathology ; Male ; Middle Aged ; Multijoint symptoms ; Osteoarthritis ; Osteoarthritis, Hip - pathology ; Osteoarthritis, Knee - pathology ; Rheumatology ; Sex ; Sex Factors</subject><ispartof>Osteoarthritis and cartilage, 2017-01, Vol.25 (1), p.53-59</ispartof><rights>2016 Osteoarthritis Research Society International</rights><rights>Copyright © 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-2e8e2dd56b6d4377664b7d7dcedc021d94a7dbc3cff0792018e40d3ea8d077933</citedby><cites>FETCH-LOGICAL-c455t-2e8e2dd56b6d4377664b7d7dcedc021d94a7dbc3cff0792018e40d3ea8d077933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1063458416302308$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27546883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perruccio, Anthony.V., PhD</creatorcontrib><creatorcontrib>Chandran, Vinod, MD, PhD</creatorcontrib><creatorcontrib>Power, J.Denise, MHSc</creatorcontrib><creatorcontrib>Kapoor, Mohit, PhD</creatorcontrib><creatorcontrib>Mahomed, Nizar N., MD, DSc</creatorcontrib><creatorcontrib>Gandhi, Rajiv, MD, MSc</creatorcontrib><title>Systemic inflammation and painful joint burden in osteoarthritis: A Matter of Sex?</title><title>Osteoarthritis and cartilage</title><addtitle>Osteoarthritis Cartilage</addtitle><description>Abstract Objective We investigated the association between serum levels of C-reactive protein (CRP) and the extent of multijoint pain among individuals with hip/knee osteoarthritis (OA) and determined whether the association differs by sex. Design Serum CRP and cartilage oligomeric matrix protein (COMP) were determined by ELISA in 189 individuals (101 female, 88 male) scheduled for total hip/knee arthroplasty for OA. Patients indicated on a homunculus all painful joints; a summed count was derived. A series of negative binomial regression models was used to investigate the cross-sectional association between painful joint count (outcome) and serum CRP concentrations, adjusting for age, sex, BMI, comorbidity count and COMP. An interaction between sex and these biomarkers was tested. Results Mean age: 66 among women, 65 among men. Women had higher mean joint count (3.7 vs 2.5, p<0.01; 4+ joint count reported by 37% women, 25% men). Median CRP concentration was higher in women (15.4 mg/l vs 9.3, p=0.07). From adjusted analyses, the effects of both ln(CRP) and ln(COMP) were modified by sex (p<0.05). Increasing ln(CRP) was associated with greater painful joint count among women, but not men. Conclusions There may be a dose-response association between painful joint burden in OA and systemic inflammation, and it appears the association is sex-specific, which may in part explain inconsistent findings in the literature. Our results underline the importance of showing sex-specific associations in OA, especially when studying the influence of inflammation.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthralgia - pathology</subject><subject>Biomarkers - blood</subject><subject>Body Mass Index</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Cartilage Oligomeric Matrix Protein - blood</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multijoint symptoms</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Hip - pathology</subject><subject>Osteoarthritis, Knee - pathology</subject><subject>Rheumatology</subject><subject>Sex</subject><subject>Sex Factors</subject><issn>1063-4584</issn><issn>1522-9653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2L1TAUxYsozof-Ay4kSzetN0nT5Ik4DMP4ASOCT9chTW4xtW2eSSq-_96UN7pw4epeLuccOL9bVc8oNBRo93JsxmBNw8regGoA6IPqnArG6l0n-MOyQ8frVqj2rLpIaQQATik8rs6YFG2nFD-vPu-PKePsLfHLMJl5NtmHhZjFkYMpp3UiY_BLJv0aHS5FRUIxBBPzt-izT6_INflocsZIwkD2-OvqSfVoMFPCp_fzsvr69vbLzfv67tO7DzfXd7Vthcg1Q4XMOdH1nWu5lF3X9tJJZ9FZYNTtWiNdb7kdBpC7UlJhC46jUQ6k3HF-Wb045R5i-LFiynr2yeI0mQXDmjRVXLSCMwFFyk5SG0NKEQd9iH428agp6I2lHvXGUm8sNShdWBbT8_v8tZ_R_bX8gVcEr08CLC1_eow6WY9LKeAj2qxd8P_Pf_OP3U5-8dZM3_GIaQxrXAo_TXViGvR---b2TNpxYBwU_w2OkZoc</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Perruccio, Anthony.V., PhD</creator><creator>Chandran, Vinod, MD, PhD</creator><creator>Power, J.Denise, MHSc</creator><creator>Kapoor, Mohit, PhD</creator><creator>Mahomed, Nizar N., MD, DSc</creator><creator>Gandhi, Rajiv, MD, MSc</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170101</creationdate><title>Systemic inflammation and painful joint burden in osteoarthritis: A Matter of Sex?</title><author>Perruccio, Anthony.V., PhD ; Chandran, Vinod, MD, PhD ; Power, J.Denise, MHSc ; Kapoor, Mohit, PhD ; Mahomed, Nizar N., MD, DSc ; Gandhi, Rajiv, MD, MSc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-2e8e2dd56b6d4377664b7d7dcedc021d94a7dbc3cff0792018e40d3ea8d077933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthralgia - pathology</topic><topic>Biomarkers - blood</topic><topic>Body Mass Index</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Cartilage Oligomeric Matrix Protein - blood</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multijoint symptoms</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Hip - pathology</topic><topic>Osteoarthritis, Knee - pathology</topic><topic>Rheumatology</topic><topic>Sex</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perruccio, Anthony.V., PhD</creatorcontrib><creatorcontrib>Chandran, Vinod, MD, PhD</creatorcontrib><creatorcontrib>Power, J.Denise, MHSc</creatorcontrib><creatorcontrib>Kapoor, Mohit, PhD</creatorcontrib><creatorcontrib>Mahomed, Nizar N., MD, DSc</creatorcontrib><creatorcontrib>Gandhi, Rajiv, MD, MSc</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoarthritis and cartilage</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perruccio, Anthony.V., PhD</au><au>Chandran, Vinod, MD, PhD</au><au>Power, J.Denise, MHSc</au><au>Kapoor, Mohit, PhD</au><au>Mahomed, Nizar N., MD, DSc</au><au>Gandhi, Rajiv, MD, MSc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic inflammation and painful joint burden in osteoarthritis: A Matter of Sex?</atitle><jtitle>Osteoarthritis and cartilage</jtitle><addtitle>Osteoarthritis Cartilage</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>25</volume><issue>1</issue><spage>53</spage><epage>59</epage><pages>53-59</pages><issn>1063-4584</issn><eissn>1522-9653</eissn><abstract>Abstract Objective We investigated the association between serum levels of C-reactive protein (CRP) and the extent of multijoint pain among individuals with hip/knee osteoarthritis (OA) and determined whether the association differs by sex. Design Serum CRP and cartilage oligomeric matrix protein (COMP) were determined by ELISA in 189 individuals (101 female, 88 male) scheduled for total hip/knee arthroplasty for OA. Patients indicated on a homunculus all painful joints; a summed count was derived. A series of negative binomial regression models was used to investigate the cross-sectional association between painful joint count (outcome) and serum CRP concentrations, adjusting for age, sex, BMI, comorbidity count and COMP. An interaction between sex and these biomarkers was tested. Results Mean age: 66 among women, 65 among men. Women had higher mean joint count (3.7 vs 2.5, p<0.01; 4+ joint count reported by 37% women, 25% men). Median CRP concentration was higher in women (15.4 mg/l vs 9.3, p=0.07). From adjusted analyses, the effects of both ln(CRP) and ln(COMP) were modified by sex (p<0.05). Increasing ln(CRP) was associated with greater painful joint count among women, but not men. Conclusions There may be a dose-response association between painful joint burden in OA and systemic inflammation, and it appears the association is sex-specific, which may in part explain inconsistent findings in the literature. Our results underline the importance of showing sex-specific associations in OA, especially when studying the influence of inflammation.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27546883</pmid><doi>10.1016/j.joca.2016.08.001</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Arthralgia - pathology Biomarkers - blood Body Mass Index C-reactive protein C-Reactive Protein - analysis Cartilage Oligomeric Matrix Protein - blood Enzyme-Linked Immunosorbent Assay Female Humans Inflammation Inflammation - pathology Male Middle Aged Multijoint symptoms Osteoarthritis Osteoarthritis, Hip - pathology Osteoarthritis, Knee - pathology Rheumatology Sex Sex Factors |
| title | Systemic inflammation and painful joint burden in osteoarthritis: A Matter of Sex? |
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