Factor VIIa-antithrombin complex: a possible new biomarker for activated coagulation

The activation of the extrinsic coagulation pathway occurs after endothelial injury when the tissue factor (TF), a transmembrane protein located outside the vasculature, binds factor VII (FVII) or activated FVII (FVIIa). Once formed, the TF-VIIa complex activates both factor IX and X and initiates t...

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Veröffentlicht in:	Clinical chemistry and laboratory medicine 2017-03, Vol.55 (4), p.484-488
Hauptverfasser:	Spiezia, Luca, Campello, Elena, Valle, Fabio Dalla, Woodhams, Barry, Simioni, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Anticoagulants Antiphospholipid antibodies Antithrombin Antithrombins - blood Antithrombins - metabolism arterial and venous thrombosis biomarker Biomarkers - blood Biomarkers - metabolism Blood Coagulation Coagulation Coagulation factor VIIa Coagulation factors Complex formation Enzyme-Linked Immunosorbent Assay Factor VIIa - analysis Factor VIIa - metabolism Female FVIIa-antithrombin Heart diseases Heart surgery Humans Inhibitors Patients Plasma levels Pre-eclampsia Pre-Eclampsia - blood Pregnancy Thrombosis - blood Tissue factor Venous Thrombosis - blood
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