Corticotropin-Releasing Factor Receptors and Their Interacting Proteins: Functional Consequences

Corticotropin-Releasing Factor Receptors and Their Interacting Proteins: Functional Consequences

The corticotropin-releasing factor (CRF) system, which is involved in stress, addiction, and anxiety disorders such as depression, acts through G-protein–coupled receptors (GPCRs) known as type-1 and type-2 CRF receptors. The purpose of this review is to highlight recent advances in the interactions...

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Veröffentlicht in:Molecular pharmacology 2016-11, Vol.90 (5), p.627-632
Hauptverfasser: Slater, Paula G., Yarur, Hector E., Gysling, Katia
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Sprache:eng
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Animals
Humans
Models, Biological
Protein Binding
Protein Multimerization
Receptors, Corticotropin-Releasing Hormone - metabolism
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container_title Molecular pharmacology
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creator Slater, Paula G.
Yarur, Hector E.
Gysling, Katia
description The corticotropin-releasing factor (CRF) system, which is involved in stress, addiction, and anxiety disorders such as depression, acts through G-protein–coupled receptors (GPCRs) known as type-1 and type-2 CRF receptors. The purpose of this review is to highlight recent advances in the interactions of CRF receptors with other GPCRs and non-GPCR proteins and their associated functional consequences. A better understanding of these interactions may generate new pharmacological alternatives for the treatment of addiction and stress-related disorders. ▪
doi_str_mv 10.1124/mol.116.104927
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subjects Animals
Humans
Models, Biological
Protein Binding
Protein Multimerization
Receptors, Corticotropin-Releasing Hormone - metabolism
title Corticotropin-Releasing Factor Receptors and Their Interacting Proteins: Functional Consequences
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