Collagen XVIII in tissue homeostasis and dysregulation — Lessons learned from model organisms and human patients

Collagen XVIII is a ubiquitous basement membrane (BM) proteoglycan produced in three tissue-specific isoforms that differ in their N-terminal non-collagenous sequences, but share collagenous and C-terminal non-collagenous domains. The collagenous domain provides flexibility to the large collagen XVI...

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Veröffentlicht in:	Matrix biology 2017-01, Vol.57-58 (1), p.55-75
Hauptverfasser:	Heljasvaara, Ritva, Aikio, Mari, Ruotsalainen, Heli, Pihlajaniemi, Taina
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animal models Animals Basement membrane Basement Membrane - drug effects Basement Membrane - metabolism Basement Membrane - pathology C-Terminus Cell culture Cell migration Cell Movement - drug effects Cell Proliferation - drug effects Cell survival Collagen Collagen (type XVIII) Collagen Type VIII - genetics Collagen Type VIII - metabolism Encephalocele Encephalocele - genetics Encephalocele - metabolism Encephalocele - pathology Endostatin Endostatins - pharmacology Endothelial cells Endothelial Cells - drug effects Frizzled protein Gene Expression Regulation Genetic disorders Heparan sulphate proteoglycan Homeostasis Homeostasis - genetics Humans Isoforms Knobloch syndrome Laminin Membranes Multiplexin Mutation Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Neovascularization, Pathologic - prevention & control Progenitor cells Protein Domains Protein Isoforms - genetics Protein Isoforms - metabolism Proteolysis Rare diseases Recombinant Proteins - pharmacology Retinal Detachment - congenital Retinal Detachment - genetics Retinal Detachment - metabolism Retinal Detachment - pathology Thrombospondin Tumors Wnt protein
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