STING and TRIF Contribute to Mouse Sepsis, Depending on Severity of the Disease Model

ABSTRACTIFN regulatory factor (IRF)3 plays a detrimental role in the cecal ligation and puncture (CLP) mouse model of sepsis. However, it is unclear which pathway activates IRF3 in this context. In this report we investigate two pathways that activate IRF3the Stimulator of Interferon Genes (STING) p...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2017-05, Vol.47 (5), p.621-631
Hauptverfasser:	Heipertz, Erica L, Harper, Jourdan, Walker, Wendy E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport - genetics Adaptor Proteins, Vesicular Transport - metabolism Animals Anti-Bacterial Agents - therapeutic use Disease Models, Animal Immunity, Innate - genetics Immunity, Innate - physiology Inflammation - genetics Inflammation - immunology Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Resuscitation Sepsis - immunology Sepsis - metabolism Sepsis - pathology
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