Downregulation of DNMT3a expression increases miR-182-induced apoptosis of ovarian cancer through caspase-3 and caspase-9-mediated apoptosis and DNA damage response

In the present study, DNA (cytosine-5)-methyltransferase 3α (DNMT3a) is explored as an anticancer molecule in ovarian cancer treatment, and also the mechanistic link between DNMT3a and its regulatory signaling pathway in Caov-3 cells is provided. Firstly, DNMT3a protein expression in 12 freshly rese...

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Veröffentlicht in:	Oncology reports 2016-12, Vol.36 (6), p.3597-3604
Hauptverfasser:	Lu, Wei, Lu, Tanmin, Wei, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Care and treatment Caspase 3 - metabolism Caspase 9 - metabolism caspase-3 caspase-9 Cell Line, Tumor Development and progression DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Damage DNA damage response DNA methylation DNMT3a Down-Regulation Female Gene Expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Humans Methyltransferases MicroRNA MicroRNAs - physiology miR-182 Mutation Ovarian cancer Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Plasmids Proto-Oncogene Proteins c-myc - metabolism RNA Interference Tumor Suppressor Protein p53 - metabolism
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