Dysregulated interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression

The overexpression of IL-12 family cytokines is implicated in the pathogenesis of SSc, but their exact role is still unclear. The aim of this study was to investigate the regulation of extracellular matrix expression by IL-23 and its contribution to the phenotype of SSc. The mRNA expression was dete...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2017-01, Vol.56 (1), p.145-155
Hauptverfasser:	Nakayama, Wakana, Jinnin, Masatoshi, Tomizawa, Yukiko, Nakamura, Kayo, Kudo, Hideo, Inoue, Kuniko, Makino, Katsunari, Honda, Noritoshi, Kajihara, Ikko, Fukushima, Satoshi, Ihn, Hironobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - toxicity Bleomycin - toxicity Cells, Cultured Collagen - metabolism Collagen Type I - drug effects Collagen Type I - metabolism Connective Tissue Growth Factor Disease Models, Animal Extracellular Matrix - metabolism Fibroblasts - drug effects Fibroblasts - immunology Fibroblasts - metabolism Fibrosis Humans Immunoblotting Immunohistochemistry Interleukin-12 - pharmacology Interleukin-23 - immunology Interleukin-23 - pharmacology Interleukin-27 - pharmacology Mice MicroRNAs - drug effects MicroRNAs - genetics Phenotype Real-Time Polymerase Chain Reaction Scleroderma, Diffuse - genetics Scleroderma, Diffuse - immunology Scleroderma, Diffuse - metabolism Signal Transduction Skin - drug effects Up-Regulation
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