Atg9A trafficking through the recycling endosomes is required for autophagosome formation

Autophagy is an intracellular degradation pathway conserved in eukaryotes. Among core autophagy-related (Atg) proteins, mammalian Atg9A is the sole multi-spanning transmembrane protein, and both of its N- and C-terminal domains are exposed to the cytoplasm. It is known that Atg9A travels through the...

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Veröffentlicht in:	Journal of cell science 2016-10, Vol.129 (20), p.3781-3791
Hauptverfasser:	Imai, Kenta, Hao, Feike, Fujita, Naonobu, Tsuji, Yasuhiro, Oe, Yukako, Araki, Yasuhiro, Hamasaki, Maho, Noda, Takeshi, Yoshimori, Tamotsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Protein Complex 2 - metabolism Amino Acid Motifs Animals Autophagosomes - metabolism Autophagy Autophagy-Related Proteins - chemistry Autophagy-Related Proteins - metabolism Endocytosis Endosomes - metabolism Gene Knockdown Techniques HeLa Cells Humans Membrane Proteins - chemistry Membrane Proteins - metabolism Mice, Knockout Models, Biological Protein Transport Salmonella - metabolism Structure-Activity Relationship trans-Golgi Network - metabolism Tyrosine - metabolism Vesicular Transport Proteins - chemistry Vesicular Transport Proteins - metabolism
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