Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD
Context: Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis. A previous study has shown that 16 weeks of supervised exercise training in NAFLD did not affect total very low-density lipop...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2016-11, Vol.101 (11), p.4219-4228 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Shojaee-Moradie, F Cuthbertson, D. J Barrett, M Jackson, N. C Herring, R Thomas, E. L Bell, J Kemp, G. J Wright, J Umpleby, A. M |
| description | Context:
Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis. A previous study has shown that 16 weeks of supervised exercise training in NAFLD did not affect total very low-density lipoprotein (VLDL) kinetics.
Objective:
The objective of the study was to determine the effect of exercise training on intrahepatocellular fat (IHCL) and the kinetics of large triglyceride (TG)-rich VLDL1 and smaller denser VLDL2, which has a lower TG content.
Design:
This was a 16-week randomized controlled trial.
Patients:
A total of 27 sedentary patients with NAFLD participated in the trial.
Intervention:
The intervention was composed of supervised exercise with moderate-intensity aerobic exercise or conventional lifestyle advice (control).
Main Outcome:
VLDL1 and VLDL2-TG and apolipoprotein B (apoB) kinetics were investigated using stable isotopes before and after the intervention.
Results:
In the exercise group, maximal oxygen uptake increased by 31% ± 6% (mean ± SEM) and IHCL decreased from 19.6% (14.8%, 30.0%) to 8.9% (5.4%, 17.3%) (median [interquartile range]) with no significant change in maximal oxygen uptake or IHCL in the control group (change between groups, P < .001 and P = .02, respectively). Exercise training increased VLDL1-TG and apoB fractional catabolic rates, a measure of clearance, (change between groups, P = .02 and P = .01, respectively), and VLDL1-apoB production rate (change between groups, P = .006), with no change in VLDL1-TG production rate. Plasma TG did not change in either group.
Conclusion:
An increased clearance of VLDL1 may contribute to the significant decrease in liver fat after 16 weeks of exercise in NAFLD. A longer duration or higher-intensity exercise interventions may be needed to lower the plasma TG and VLDL production rate.
A 16-week exercise improved fitness and reduced liver fat by 50% in men with NAFLD and increased clearance of both VLDL1 TG and apoB. However the liver continued to export large amounts of VLDL-TG. |
| doi_str_mv | 10.1210/jc.2016-2353 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1835428792</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1835428792</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4181-300edd9b32e51d9ebaa1ee79d35d129f3fa0520f1928538cfaa38f8c03777aa53</originalsourceid><addsrcrecordid>eNptkEFv1DAQRi1ERZfCjTPykQNpPXZcO8ey7ZZKUYuqgrhZXmdCE7L2YieU_vs6SuGED7b86c2n0SPkHbBj4MBOenfMGZwWXEjxgqygKmWhoFIvyYoxDkWl-PdD8jqlnjEoSylekUOupBalkivSX_zB6LqE9C7aznf-B73FZnKYaN39xkg3dqTWN_TKu4g25fzWjvkOLf1Wn9d0PaCN1jukn6aRXodxib_EkFvGLnjaeXp9tqnP35CD1g4J3z6_R-Tr5uJu_bmoby6v1md14UrQUAjGsGmqreAooalway0gqqoRsgFetaK1THLWQsW1FNq11grdaseEUspaKY7Ih6V3H8OvCdNodl1yOAzWY5iSAS1kybWqeEY_LqiLIaWIrdnHbmfjowFmZrumd2a2a2a7GX__3Dxtd9j8g__qzEC5AA9hGDGmn8P0gNHcox3Ge8PyKU-VLuZGgPwr5gTymFjG0DfBxc7jPmJKpg9T9FnV_7d5AroQk_g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1835428792</pqid></control><display><type>article</type><title>Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Shojaee-Moradie, F ; Cuthbertson, D. J ; Barrett, M ; Jackson, N. C ; Herring, R ; Thomas, E. L ; Bell, J ; Kemp, G. J ; Wright, J ; Umpleby, A. M</creator><creatorcontrib>Shojaee-Moradie, F ; Cuthbertson, D. J ; Barrett, M ; Jackson, N. C ; Herring, R ; Thomas, E. L ; Bell, J ; Kemp, G. J ; Wright, J ; Umpleby, A. M</creatorcontrib><description>Context:
Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis. A previous study has shown that 16 weeks of supervised exercise training in NAFLD did not affect total very low-density lipoprotein (VLDL) kinetics.
Objective:
The objective of the study was to determine the effect of exercise training on intrahepatocellular fat (IHCL) and the kinetics of large triglyceride (TG)-rich VLDL1 and smaller denser VLDL2, which has a lower TG content.
Design:
This was a 16-week randomized controlled trial.
Patients:
A total of 27 sedentary patients with NAFLD participated in the trial.
Intervention:
The intervention was composed of supervised exercise with moderate-intensity aerobic exercise or conventional lifestyle advice (control).
Main Outcome:
VLDL1 and VLDL2-TG and apolipoprotein B (apoB) kinetics were investigated using stable isotopes before and after the intervention.
Results:
In the exercise group, maximal oxygen uptake increased by 31% ± 6% (mean ± SEM) and IHCL decreased from 19.6% (14.8%, 30.0%) to 8.9% (5.4%, 17.3%) (median [interquartile range]) with no significant change in maximal oxygen uptake or IHCL in the control group (change between groups, P < .001 and P = .02, respectively). Exercise training increased VLDL1-TG and apoB fractional catabolic rates, a measure of clearance, (change between groups, P = .02 and P = .01, respectively), and VLDL1-apoB production rate (change between groups, P = .006), with no change in VLDL1-TG production rate. Plasma TG did not change in either group.
Conclusion:
An increased clearance of VLDL1 may contribute to the significant decrease in liver fat after 16 weeks of exercise in NAFLD. A longer duration or higher-intensity exercise interventions may be needed to lower the plasma TG and VLDL production rate.
A 16-week exercise improved fitness and reduced liver fat by 50% in men with NAFLD and increased clearance of both VLDL1 TG and apoB. However the liver continued to export large amounts of VLDL-TG.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2016-2353</identifier><identifier>PMID: 27583475</identifier><language>eng</language><publisher>United States: Endocrine Society</publisher><subject>Adiposity ; Apolipoproteins B - blood ; Apolipoproteins B - metabolism ; Exercise Therapy - methods ; Humans ; Kinetics ; Lipoproteins, VLDL - blood ; Lipoproteins, VLDL - metabolism ; Liver - metabolism ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease - metabolism ; Non-alcoholic Fatty Liver Disease - therapy ; Outcome Assessment, Health Care ; Sedentary Behavior ; Triglycerides - blood ; Triglycerides - metabolism</subject><ispartof>The journal of clinical endocrinology and metabolism, 2016-11, Vol.101 (11), p.4219-4228</ispartof><rights>Copyright © 2016 by the Endocrine Society</rights><rights>Copyright © 2016 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4181-300edd9b32e51d9ebaa1ee79d35d129f3fa0520f1928538cfaa38f8c03777aa53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27583475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shojaee-Moradie, F</creatorcontrib><creatorcontrib>Cuthbertson, D. J</creatorcontrib><creatorcontrib>Barrett, M</creatorcontrib><creatorcontrib>Jackson, N. C</creatorcontrib><creatorcontrib>Herring, R</creatorcontrib><creatorcontrib>Thomas, E. L</creatorcontrib><creatorcontrib>Bell, J</creatorcontrib><creatorcontrib>Kemp, G. J</creatorcontrib><creatorcontrib>Wright, J</creatorcontrib><creatorcontrib>Umpleby, A. M</creatorcontrib><title>Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context:
Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis. A previous study has shown that 16 weeks of supervised exercise training in NAFLD did not affect total very low-density lipoprotein (VLDL) kinetics.
Objective:
The objective of the study was to determine the effect of exercise training on intrahepatocellular fat (IHCL) and the kinetics of large triglyceride (TG)-rich VLDL1 and smaller denser VLDL2, which has a lower TG content.
Design:
This was a 16-week randomized controlled trial.
Patients:
A total of 27 sedentary patients with NAFLD participated in the trial.
Intervention:
The intervention was composed of supervised exercise with moderate-intensity aerobic exercise or conventional lifestyle advice (control).
Main Outcome:
VLDL1 and VLDL2-TG and apolipoprotein B (apoB) kinetics were investigated using stable isotopes before and after the intervention.
Results:
In the exercise group, maximal oxygen uptake increased by 31% ± 6% (mean ± SEM) and IHCL decreased from 19.6% (14.8%, 30.0%) to 8.9% (5.4%, 17.3%) (median [interquartile range]) with no significant change in maximal oxygen uptake or IHCL in the control group (change between groups, P < .001 and P = .02, respectively). Exercise training increased VLDL1-TG and apoB fractional catabolic rates, a measure of clearance, (change between groups, P = .02 and P = .01, respectively), and VLDL1-apoB production rate (change between groups, P = .006), with no change in VLDL1-TG production rate. Plasma TG did not change in either group.
Conclusion:
An increased clearance of VLDL1 may contribute to the significant decrease in liver fat after 16 weeks of exercise in NAFLD. A longer duration or higher-intensity exercise interventions may be needed to lower the plasma TG and VLDL production rate.
A 16-week exercise improved fitness and reduced liver fat by 50% in men with NAFLD and increased clearance of both VLDL1 TG and apoB. However the liver continued to export large amounts of VLDL-TG.</description><subject>Adiposity</subject><subject>Apolipoproteins B - blood</subject><subject>Apolipoproteins B - metabolism</subject><subject>Exercise Therapy - methods</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Lipoproteins, VLDL - blood</subject><subject>Lipoproteins, VLDL - metabolism</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Non-alcoholic Fatty Liver Disease - metabolism</subject><subject>Non-alcoholic Fatty Liver Disease - therapy</subject><subject>Outcome Assessment, Health Care</subject><subject>Sedentary Behavior</subject><subject>Triglycerides - blood</subject><subject>Triglycerides - metabolism</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEFv1DAQRi1ERZfCjTPykQNpPXZcO8ey7ZZKUYuqgrhZXmdCE7L2YieU_vs6SuGED7b86c2n0SPkHbBj4MBOenfMGZwWXEjxgqygKmWhoFIvyYoxDkWl-PdD8jqlnjEoSylekUOupBalkivSX_zB6LqE9C7aznf-B73FZnKYaN39xkg3dqTWN_TKu4g25fzWjvkOLf1Wn9d0PaCN1jukn6aRXodxib_EkFvGLnjaeXp9tqnP35CD1g4J3z6_R-Tr5uJu_bmoby6v1md14UrQUAjGsGmqreAooalway0gqqoRsgFetaK1THLWQsW1FNq11grdaseEUspaKY7Ih6V3H8OvCdNodl1yOAzWY5iSAS1kybWqeEY_LqiLIaWIrdnHbmfjowFmZrumd2a2a2a7GX__3Dxtd9j8g__qzEC5AA9hGDGmn8P0gNHcox3Ge8PyKU-VLuZGgPwr5gTymFjG0DfBxc7jPmJKpg9T9FnV_7d5AroQk_g</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Shojaee-Moradie, F</creator><creator>Cuthbertson, D. J</creator><creator>Barrett, M</creator><creator>Jackson, N. C</creator><creator>Herring, R</creator><creator>Thomas, E. L</creator><creator>Bell, J</creator><creator>Kemp, G. J</creator><creator>Wright, J</creator><creator>Umpleby, A. M</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201611</creationdate><title>Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD</title><author>Shojaee-Moradie, F ; Cuthbertson, D. J ; Barrett, M ; Jackson, N. C ; Herring, R ; Thomas, E. L ; Bell, J ; Kemp, G. J ; Wright, J ; Umpleby, A. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4181-300edd9b32e51d9ebaa1ee79d35d129f3fa0520f1928538cfaa38f8c03777aa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adiposity</topic><topic>Apolipoproteins B - blood</topic><topic>Apolipoproteins B - metabolism</topic><topic>Exercise Therapy - methods</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Lipoproteins, VLDL - blood</topic><topic>Lipoproteins, VLDL - metabolism</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Non-alcoholic Fatty Liver Disease - metabolism</topic><topic>Non-alcoholic Fatty Liver Disease - therapy</topic><topic>Outcome Assessment, Health Care</topic><topic>Sedentary Behavior</topic><topic>Triglycerides - blood</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shojaee-Moradie, F</creatorcontrib><creatorcontrib>Cuthbertson, D. J</creatorcontrib><creatorcontrib>Barrett, M</creatorcontrib><creatorcontrib>Jackson, N. C</creatorcontrib><creatorcontrib>Herring, R</creatorcontrib><creatorcontrib>Thomas, E. L</creatorcontrib><creatorcontrib>Bell, J</creatorcontrib><creatorcontrib>Kemp, G. J</creatorcontrib><creatorcontrib>Wright, J</creatorcontrib><creatorcontrib>Umpleby, A. M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shojaee-Moradie, F</au><au>Cuthbertson, D. J</au><au>Barrett, M</au><au>Jackson, N. C</au><au>Herring, R</au><au>Thomas, E. L</au><au>Bell, J</au><au>Kemp, G. J</au><au>Wright, J</au><au>Umpleby, A. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2016-11</date><risdate>2016</risdate><volume>101</volume><issue>11</issue><spage>4219</spage><epage>4228</epage><pages>4219-4228</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Context:
Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis. A previous study has shown that 16 weeks of supervised exercise training in NAFLD did not affect total very low-density lipoprotein (VLDL) kinetics.
Objective:
The objective of the study was to determine the effect of exercise training on intrahepatocellular fat (IHCL) and the kinetics of large triglyceride (TG)-rich VLDL1 and smaller denser VLDL2, which has a lower TG content.
Design:
This was a 16-week randomized controlled trial.
Patients:
A total of 27 sedentary patients with NAFLD participated in the trial.
Intervention:
The intervention was composed of supervised exercise with moderate-intensity aerobic exercise or conventional lifestyle advice (control).
Main Outcome:
VLDL1 and VLDL2-TG and apolipoprotein B (apoB) kinetics were investigated using stable isotopes before and after the intervention.
Results:
In the exercise group, maximal oxygen uptake increased by 31% ± 6% (mean ± SEM) and IHCL decreased from 19.6% (14.8%, 30.0%) to 8.9% (5.4%, 17.3%) (median [interquartile range]) with no significant change in maximal oxygen uptake or IHCL in the control group (change between groups, P < .001 and P = .02, respectively). Exercise training increased VLDL1-TG and apoB fractional catabolic rates, a measure of clearance, (change between groups, P = .02 and P = .01, respectively), and VLDL1-apoB production rate (change between groups, P = .006), with no change in VLDL1-TG production rate. Plasma TG did not change in either group.
Conclusion:
An increased clearance of VLDL1 may contribute to the significant decrease in liver fat after 16 weeks of exercise in NAFLD. A longer duration or higher-intensity exercise interventions may be needed to lower the plasma TG and VLDL production rate.
A 16-week exercise improved fitness and reduced liver fat by 50% in men with NAFLD and increased clearance of both VLDL1 TG and apoB. However the liver continued to export large amounts of VLDL-TG.</abstract><cop>United States</cop><pub>Endocrine Society</pub><pmid>27583475</pmid><doi>10.1210/jc.2016-2353</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0021-972X 1945-7197 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adiposity Apolipoproteins B - blood Apolipoproteins B - metabolism Exercise Therapy - methods Humans Kinetics Lipoproteins, VLDL - blood Lipoproteins, VLDL - metabolism Liver - metabolism Male Middle Aged Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - therapy Outcome Assessment, Health Care Sedentary Behavior Triglycerides - blood Triglycerides - metabolism |
| title | Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD |
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